The Response of Total and Regional Cerebral Blood Flow to Dexamethsone (Dex) Infusion in New Born Piglets During Normoxia

Stiris, Tom; García-Alix, A.; Blanco, D.; Cabañas, Fernando; Pellicer, A; Quero, J; Bratlid, Dag

doi:10.1203/00006450-199402000-00091

Cited by 2 publications

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“…In summary, our study showed substantial changes in brain circulation after systemic dexamethasone, which concurs with our findings in studies in neonatal animal models8 9 and in human preterm infants 10. These changes indicate that dexamethasone has a direct vasodilator effect.…”

Section: Discussionsupporting

confidence: 92%

“…This motivated us to investigate the haemodynamic consequences of systemic dexamethasone on the central nervous system. Initially, we studied the effects of dexamethasone on the brain8 and eye9 in newborn pigs and found that dexamethasone increased cerebral and retinal blood flow according to radiolabelled microspheres during normoxia. Our next step was to study preterm infants who received dexamethasone to prevent chronic lung disease,10 in whom we found a significant increase in cerebral and ocular blood flow velocity after they received dexamethasone.…”

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confidence: 99%

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Cerebral haemodynamics in preterm infants after exposure to dexamethasone

Pellicer¹,

Gayá²,

Stiris³

et al. 1998

Archives of Disease in Childhood - Fetal and Neonatal Edition

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Aim-To determine changes in brain haemodynamics produced by dexamethasone; to evaluate the pathophysiological conditions involved in the eVect of dexamethasone. Methods-A prospective study was made of 12 ventilated preterm infants who received dexamethasone (0.25 mg/kg/12 hours) for ongoing chronic lung disease or extubation failure. Cerebral blood flow (CBF), absolute cerebral blood volume (CBV), and cerebral blood volume changes ( CBV) were estimated by near infrared spectroscopy, before and 10, 30, 60, 120, 180 and 240 minutes after the first, third, and fifth doses of dexamethasone. All patients were monitored continuously using pulse oximetry, transcutaneous blood gases, and blood pressure. Results-There were significant short term changes in CBV on each day of the study; CBV increased significantly at 240 minutes compared with values before the first dose, and from 120 minutes onward during the third and fifth doses. However, mean CBV values averaged over 240 minutes after the first, third, and fifth doses did not vary. Mean CBF values averaged over 240 minutes increased progressively up to the fifth dose (significant differences between the first and fifth dose). The short term changes in CBF consisted of a significant increase 60 minutes after dexamethasone administration compared with the before and 10 minute values in every study. Blood pressure was significantly higher in the third and fifth doses than in the first dose. Blood pressure showed no short term changes. There was no correlation between CBF and blood pressure changes. TcPCO 2 (transcutaneous PCO 2 ) decreased significantly throughout the study period, with the average mean value in the fifth dose significantly lower than in the first dose. Nevertheless, no short term changes in TcPCO 2 were observed. Conclusions-Postnatal systemic dexamethasone administration produced significant changes in cerebral haemodynamics that seemed to be related to both a direct eVect on regional vessel walls and the cumulative eVect of dexamethasone. (Arch Dis Child Fetal Neonatal Ed 1998;79:F123-F128)

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Section: Discussionsupporting

confidence: 92%

mentioning

confidence: 99%

Cerebral haemodynamics in preterm infants after exposure to dexamethasone

Pellicer¹,

Gayá²,

Stiris³

et al. 1998

Archives of Disease in Childhood - Fetal and Neonatal Edition

View full text Add to dashboard Cite

show abstract

“…We have previously demonstrated in newborn piglets that DEX increases retinal and cerebral blood flow measured by radiolabelled microspheres during normoxia [34,35]. Nevertheless, clinical studies investigating DEX as a potential risk factor for the development of severe retinopathy of prematurity are inconclusive [2,4,32].…”

Section: Introductionmentioning

confidence: 99%