The Response to Varying Concentrations of Inhaled Nitric Oxide in Patients with Acute Respiratory Distress Syndrome

Nitric oxide contamination of hospital compressed air improves gas exchange in patients with acute lung injury

“…These changes reflect a functional response of the lungs to very low levels of inhaled NO. The increased PaO 2 is most likely due to an improvement in ventilation-perfusion matching because hemodynamics, PaCO 2 , ventilatory settings, and SvO 2 remained unchanged [24].…”

Effect of inhaled nitric oxide in combination with almitrine on ventilation-perfusion distributions in experimental lung injury

“…Regarding MPAP, we observed only a small, although significant decrease, which may be due to individual differences in the response to the single dose of 10 ppm NO used in our investigation. In clinical routine, a dose-response study is usually performed prior to the treatment with inhaled NO to reveal the dose with the best impact on gas exchange and pulmonary artery pressure [25,26,27,28]. Intravascular NO is known to be rapidly bound to Hb, which is transformed to MetHb in the presence of oxygen.…”

Hypoxic Pulmonary Vasoconstriction

“…The most frequently tested vasodilator in ALI/ARDS has been inhaled NO, which almost always decreased shunt and increased P a O 2 in association with decreased P PA and unaltered Q (181, 391, 417, 583, 695,981,1136,1213,1414,1554,1555,1557,1561,1661,1668,1998,2228). These decreases in shunt and P PA were probably due to NO-induced reversal of vasoconstriction in ventilated lung, causing redistribution of flow to ventilated lung from shunt regions.…”