The results of combined ozone therapy using in complex treatment of soft tissues infections in patients with diabetes mellitus type II

Винник, Ю. С.; Салмина, А. Б.; Теплякова, О. В.; Drobushevskaia, A I; Пожиленкова, Е. А.; Моргун, А. В.; Shapran, M V; Коваленко, А. О.

doi:10.17116/hirurgia2015263-69

Cited by 6 publications

(4 citation statements)

References 9 publications

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“…Ozone therapy has also demonstrated the ability to inhibit the production of cytokines such as IL-6 and TNF-α. Lower levels of these cytokines are beneficial for promoting the healing and repair of wounds ( 26 , 27 ). Supporting our findings, our study also demonstrated lower levels of IL-6 and TNF-α in the ozone therapy group.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the healing potential of short-term ozone therapy for the treatment of diabetic foot ulcers

Sun,

Heng,

Liu

et al. 2024

Front. Endocrinol.

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BackgroundThe availability of research on short-term ozone therapy for diabetic foot ulcers (DFUs) is limited, and even when it is accessible, it mainly comprises of basic analysis conducted during long-term ozone therapy. This study was to evaluate the efficacy of short-term ozone therapy in promoting wound healing in DFUs.MethodsA retrospective analysis was conducted on 89 patients with type 2 diabetes complicated by DFUs. The patients were divided into two groups: ozone therapy group (n=41) and control group (n=48). Wound condition, change of bacterial types, changes in inflammatory indicators (erythrocyte sedimentation rate [ESR], C-reactive protein [CRP], and procalcitonin [PCT]), vascular endothelial growth factor (VEGF), cytokines [Interleukin 6 (IL-6) and tumor necrosis factor-α(TNF-α)], and oxidative stress levels (superoxide dismutase [SOD], malondialdehyde [MDA], and total antioxidant capacity [T-AOC]) were observed pre-treatment and after 1 week. After a 12-week of follow-up, wound healing rate, amputation rate, inpatient day, duration of antibiotics, reinfection rate, incidence of new ulcers, readmission rate, and reoperation rate, and cumulative wound healing rate using Kaplan-Meier curves were assessed.ResultsAfter 1 week of treatment, the ozone therapy group showed higher VEGF, SOD, and T-AOC levels compared to the control group (P<0.05), while CRP, PCT, ESR, IL-6, TNF-α, MDA levels and bacterial types were lower (P<0.05). The ozone therapy group had a higher wound healing rate after a 12-week follow-up (P<0.05). Kaplan-Meier curves indicated a higher cumulative wound healing rate in the ozone therapy group (P<0.05). Additionally, the ozone therapy group had lower inpatient day, duration of antibiotics, reinfection rate, and readmission rate compared to the control group (P<0.05).ConclusionShort-term ozone therapy is effective in promoting wound healing in DFUs by reducing inflammation, increasing growth factor levels, improving oxidative stress status, shortening healing time, and improving long-term prognosis. These findings suggest the potential of short-term ozone therapy as a valuable treatment modality for DFUs.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the healing potential of short-term ozone therapy for the treatment of diabetic foot ulcers

Sun,

Heng,

Liu

et al. 2024

Front. Endocrinol.

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“…[ 53 ] Systemic OT can decrease IL-6 and other pro-inflammatory cytokines. [ 54 ] It has also been measured in vivo that the release of numerous cytokines from ozonated blood, at a concentration between 30 and 55 μg/mL, causes an increase in interferon production and less production of tumor necrosis factor α[ 55 ] and IL-2. [ 56 ]…”

Section: Discussionmentioning

confidence: 99%

Clinical effectiveness of medical ozone therapy in COVID-19

Serra¹,

Baeza-Noci²,

Abdala

et al. 2023

Medical Gas Research

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Ozone therapy (OT), a medical procedure, has been showing good results during the coronavirus disease (COVID-19). We aimed to build an evidence and gaps map (EGM) of OT in the COVID-19 ranking the articles found according to levels of evidence and outcomes. The EGM brings bubbles of different sizes and different colors according to the articles. The OT intervention used was major or minor autohemotherapy, rectal insufflation and ozonized saline solution. EGM was based on 13 clinical studies using OT for COVID-19 involving a total of 271 patients. We found 30 outcomes related to OT in COVID-19. Our EGM divided the outcomes into six groups: 1-clinical improvement; 2-hospitalization; 3-inflammatory, thromboembolic, infectious, or metabolic markers; 4-radiological aspects, 5-viral infection and 6-adverse events. Major autohemotherapy was present in 19 outcomes, followed by rectal insufflation. Improvement in clinical symptoms of COVID-19, improvement of respiratory function, improvement of oxygen saturation, reduction in hospital internment, decrease in C-reactive protein, decrease in ferritin, decrease in lactate dehydrogenase, decrease in interleukin 6, decrease in D-dimer, radiological improvement of lung lesions and absence of reported adverse events were related in the papers. The most commonly used concentrations of OT in major autohemotherapy and in rectal insufflation were 40 μg/mL and 35 μg/mL, respectively. Here, we bring the first EGM showing the efficacy and safety of OT in the treatment of COVID-19. OT can be used as integrative medical therapy in COVID-19 at a low cost and improve the health conditions of the patients.

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“…It can be used effectively in both gram negative and gram positive bacteria, virus and fungal infections [15,16]. The mechanism of action of ozone oil provides skin oxygenation, increases microcirculation, triggers tissue repair and regeneration, slows the skin aging process.…”

Section: Discussionmentioning

confidence: 99%

The Effectiveness of Ozone Therapy in the Patient with Necrotic Vasculitis Wound

Alp

2021

BJSTR

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Necrotic wounds are common injuries in many patients hospitalized in intensive care. Ozone therapy has been used as a complement to modern medicine since 1902 in the treatment of diabetes. It has been used in our country since 1999. With ozone therapy (O 3 ), microcirculation improves 20-60% in the circulation in 12-14 days, and 10-40% in the venous part. Ozone therapy has been shown to reduce proinflammatory cytokines in soft tissue infections. This method of treatment will provide significant benefits if used in addition to modern medicine.

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The results of combined ozone therapy using in complex treatment of soft tissues infections in patients with diabetes mellitus type II

Cited by 6 publications

References 9 publications

Evaluation of the healing potential of short-term ozone therapy for the treatment of diabetic foot ulcers

Evaluation of the healing potential of short-term ozone therapy for the treatment of diabetic foot ulcers

Clinical effectiveness of medical ozone therapy in COVID-19

The Effectiveness of Ozone Therapy in the Patient with Necrotic Vasculitis Wound

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