The results of functional endoscopic sinus (FES) surgery on the symptoms of patients with cystic fibrosis

Jones, John W.; Parsons, David; Cuyler, J. P.

doi:10.1016/0165-5876(93)90143-q

Cited by 79 publications

(62 citation statements)

References 15 publications

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“…Patient B42 also did not have recurrent colonizations after the second surgery until conclusion of the study in July 2009, and small reductions in lower airway colonization frequencies were seen for a couple of the other patients (Supplementary Table S1). These findings suggest that the sinus populations are intermittently seeding the lower airways, and that removal of these may offer a temporary relief of sinus symptoms and possibly lung colonization events (HK Johansen, personal communication; Jones et al, 1993;Nishioka et al, 1995). On the basis of colony morphology and other phenotypic characteristics, we have constructed a model for a tentative development of the sinus populations of P. aeruginosa in patient B22 (Figure 4).…”

Section: Mic ( G/ml)mentioning

confidence: 99%

Evolution and diversification of Pseudomonas aeruginosa in the paranasal sinuses of cystic fibrosis children have implications for chronic lung infection

et al. 2011

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The opportunistic pathogen Pseudomonas aeruginosa is a frequent colonizer of the airways of patients suffering from cystic fibrosis (CF). Depending on early treatment regimens, the colonization will, with high probability, develop into chronic infections sooner or later, and it is important to establish under which conditions the switch to chronic infection takes place. In association with a recently established sinus surgery treatment program for CF patients at the Copenhagen CF Center, colonization of the paranasal sinuses with P. aeruginosa has been investigated, paralleled by sampling of sputum from the same patients. On the basis of genotyping and phenotypic characterization including transcription profiling, the diversity of the P. aeruginosa populations in the sinuses and the lower airways was investigated and compared. The observations made from several children show that the paranasal sinuses constitute an important niche for the colonizing bacteria in many patients. The paranasal sinuses often harbor distinct bacterial subpopulations, and in the early colonization phases there seems to be a migration from the sinuses to the lower airways, suggesting that independent adaptation and evolution take place in the sinuses. Importantly, before the onset of chronic lung infection, lineages with mutations conferring a large fitness benefit in CF airways such as mucA and lasR as well as small colony variants and antibiotic-resistant clones are part of the sinus populations. Thus, the paranasal sinuses potentially constitute a protected niche of adapted clones of P. aeruginosa, which can intermittently seed the lungs and pave the way for subsequent chronic lung infections.

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Section: Mic ( G/ml)mentioning

confidence: 99%

Evolution and diversification of Pseudomonas aeruginosa in the paranasal sinuses of cystic fibrosis children have implications for chronic lung infection

et al. 2011

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“…1471 Outside of the transplant literature, pulmonary outcomes for CF patients are mixed despite improved QoL. 1469,1472 Because of the pooling of maxillary sinus secretions seen in CF patients and the frequent need for revision ESS procedures, emerging literature suggests that a widened/inferiorly-extended maxillary sinus antrostomy surgery may permit improved drainage and larger volume irrigant delivery. 1473 …”

Section: Xiic Rs Special Considerations: Cfmentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

559

888

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Background:The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). Methods:Evidence-based reviews with recommendations (EBRRs) were developed for scores of topics, using previously reported methodology. Where existing evidence was insufficient for an EBRR, an evidence-based review (EBR) was produced. The sections were then synthesized and the entire manuscript was then reviewed by all authors for consensus. Results:The resulting ICAR:RS document addresses multiple topics in RS, including acute RS (ARS), chronic RS (CRS) with and without nasal polyps (CRSwNP and CRSsNP), recurrent acute RS (RARS), acute exacerbation of CRS (AE-CRS), and pediatric RS. Conclusion:As a critical review of the RS literature, ICAR:RS provides a thorough review of pathophysiology and evidence-based recommendations for medical and surgical treatment. It also demonstrates the significant gaps in our understanding of the pathophysiology and optimal management of RS. Too o en the foundation upon which these recommendations are based is comprised of lowerlevel evidence. It is our hope that this summary of the evidence in RS will point out where additional research efforts may be directed. C 2016 ARS-AAOA, LLC. Key Words:rhinosinusitis; chronic rhinosinusitis; acute rhinosinusitis; recurrent acute rhinosinusitis; evidence-based medicine; systematic review; endoscopic sinus surgery List of Abbreviations Used

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“…В другом ретроспективном исследовании была оценена связь между МВ и эндоскопической сину-сотомией [32]. Пациенты с диагностированным ра-нее МВ в сочетании с хроническим риносинуситом (16 детей и 1 взрослый), которые не поддавались консервативному лечению, подверглись эндоско-пической синусотомии.…”

Section: хирургическое лечениеunclassified