The results of intraoperative consultations in 181 ductal carcinomas in situ of the breast

Abstract

respectively. Sampling error was the main reason for the low detection rate, and technical inadequacy was a major factor contributing to interpretive problems. In multivariate regression analysis, FS accuracy was significantly associated with the clinical presentation of a palpable mass (odds ratio [OR] Å 4.16, 95% confidence interval [CI]: 2.04-8.45), the macroscopic finding of a mass (OR Å 3.03, 95% CI: 1.45-6.67), and necrosis (OR Å 3.13, 95% CI: 1.4-6.67). CONCLUSIONS.The authors concluded that the accuracy of FS diagnosis of DCIS was low, mainly due to sampling error. In general, FS examination should not be performed when no lesion/mass is identified by macroscopic examination. Cancer

Deep learning-enabled realistic virtual histology with ultraviolet photoacoustic remote sensing microscopy

“…Adipose tissue in particular can be challenging to cut for frozen section analysis, often leading to tissue fragmentation and folding, or an increase in thickness. Given the technical limitations in quality and diagnostic utility, several studies have found false negative rates as high as 36% for frozen sections compared to permanent FFPE sections in certain procedures such as radical prostatectomy and breast-conserving surgery [44][45][46] . In many cancer types, concordance between frozen sections and permanent sections is high, but some cancer types such as melanoma show poor agreement 47 .…”

Accuracy of frozen section diagnoses of breast lesions after introduction of a national programme in mammographic screening

“…Although frozen section examinations have been described by many authors as a reliable method, it is nevertheless important to stress that its accuracy depends on multiple factors such as the indication, the organ, the precise anatomic site of the lesion, the quality of the material to be examined, the quality of the slides, and the experience of the technician and the pathologist 1–8 , 12 . Depending on the specialization of the ‘submitting’ hospitals, some pathology departments receive more or less specimens of a specific organ.…”

“…intraluminal benign vs. malignant epithelial proliferations or glandular typical vs. atypical hyperplasia) 21 , 24 , 27 , 28 . The accuracy of frozen section in the diagnosis of borderline non‐invasive or preinvasive breast lesions is uncertain 3 . Also, the combined interpretation of macroscopic and microscopic examinations of fresh breast biopsies is important and knowledge of all relevant clinical data is crucial 27 .…”

“…The frozen section method was first introduced in 1891 and constitutes even today an important preoperative diagnostic procedure on fresh specimens which is usually rapid and reliable 1–8 . It is generally accepted that frozen section consultations should be used only when the result influences the surgical strategy, the risk of mutilating consequences being too great.…”

Deep learning-enabled realistic virtual histology with ultraviolet photoacoustic remote sensing microscopy

“…Conventional alternatives to FFPE H&E histopathology exist to offer rapid assessment of margin status while the patient remains in the surgical suite, though they suffer from limitations in technical quality and diagnostic accuracy in some applications 3 – 7 . Frozen section analysis (FSA) can generate slides available for brightfield microscopy in approximately 20 mins, which is considerably faster than FFPE permanent sectioning.…”