Summary: Purpose:We investigated whether interictal F-18 fluorodeoxyglucose positron emission tomography ([ 18 F]FDG-PET) or ictal [ 99m Tc]-HMPAO single-photon emission computed tomography (SPECT) was useful to find epileptogenic zones in occipital lobe epilepsy (OLE).Methods: We reviewed visually and quantified patterns of hypometabolism in interictal [ 18 F]FDG-PET and those of hyperperfusion in ictal SPECT in 17 OLE patients (27 ± 6.8 years old; M/F, 10/7; injection time, 30 ± 17 s). OLE was diagnosed based on invasive electroencephalography, surgery, and postsurgical outcome (Engel class I in all at an average of 26 months after surgery).Results: Epileptogenic zones were correctly localized in nine (60%) of 15 patients by interictal [ 18 F]FDG-PET, and asymmetric indices corroborated visual diagnosis. Epileptogenic hemispheres were correctly lateralized in 14 (93%) of 15 patients on [ 18 F]FDG-PET. Epileptogenic hemispheres were correctly lateralized in 13 (76%) of 17 patients using ictal SPECT, but localization was possible in only five (29%) patients. Interictal [ 18 F]FDG-PET was helpful in two of the patients who showed no abnormality on magnetic resonance imaging (MRI) and no possible localization with ictal SPECT.Conclusions: In OLE, ictal SPECT was helpful in lateralization, but less helpful in localization. Interictal [ 18 F]FDG-PET was helpful in localization or lateralization of epileptogenic zones, even in patients with ambiguous MRI or ictal SPECT findings.