The Results of X-Ray Treatment in Undifferentiated Carcinoma of the Thyroid

Smedal, Magnus I.; Meissner, William A.

doi:10.1148/76.6.927

Cited by 26 publications

(12 citation statements)

References 2 publications

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“…In fact the tumour increased in size during the time of irradiation, which corresponds to our previous experiences with this condition as well as with that of other authors (SMEDAL & MEISSNER 1961, SHELINE et coll. 1966, BEEMER & BAKER 1970.…”

Section: Discussionsupporting

confidence: 92%

Combined Chemotherapy and Radiation Therapy in Spindle and Giant Cell Carcinoma of the Thyroid Gland: Report of a case

Wallgren¹,

Norin²

1973

Acta Radiologica: Therapy, Physics, Biology

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Section: Discussionsupporting

confidence: 92%

Combined Chemotherapy and Radiation Therapy in Spindle and Giant Cell Carcinoma of the Thyroid Gland: Report of a case

Wallgren¹,

Norin²

1973

Acta Radiologica: Therapy, Physics, Biology

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“…The response to irradiation is quite variable. 41 Complete regression of disease occasionally occurs; usually, however, the residual disease shrinks minimally, or the mass softens. Just as freqently, there is rapid regrowth after cessation of therapy.…”

Section: Casementioning

confidence: 99%

“…Thyrotropin stimulating hormone (TSH) suppression and radioactive iodine therapy, the mainstays of treating differentiated carcinoma of the thyroid, have no place in the treatment of spindle and giant cell carcinoma, not withstanding two previous reports. ' *" Most investigators 14,26,27,36,42 agree that a n attempt at surgical removal of all 2272 CANCER June 1978Vol 41.…”

mentioning

confidence: 99%

Anaplastic carcinoma of the thyroid.A review of 84 cases of spindle and giant cell carcinoma of the thyroid

Aldinger

Samaan

Ibañez

et al. 1978

Cancer

336

121

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Eighty-four cases of spindle and giant cell carcinoma of the thyroid were reviewed. This is a swiftly growing, and rapidly fatal neoplasm that generally develops in the elderly. Treatment of this disease was generally unsuccessful with a 7.1% five-year survival rate and a mean survival period of 6.2 months from the time of tissue diagnosis. In the majority of cases, areas of well-differentiated thyroid carcinoma could be identified, supporting the concept that spindle and giant cell carcinoma results from the transformation of preexisting well-differentiated thyroid carcinoma. Because of the aggressive biologic activity of this neoplasm, we treat all cases as disseminated disease at the time of presentation. Our best therapeutic results have been obtained with a combination of surgery, irradiation, and chemotherapy; however, these results still leave much to be desired. Patients with only small foci of spindle and giant cell carcinoma, at the time of diagnosis, may have a better chance of prolonged survival.

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“…Sheline et al [5], Smedal and M eissner [6], Smedal et al [7], H o w a r d and Smithers [2] and T aylor and D avis [8] have discussed the role of irradiation in this disease with varying points of view. There is inappropriate emphasis on irradiation in anaplastic carcinoma, since this disease often progresses so rapidly that there is not enough time for post operative irradiation.…”

Section: Introductionmentioning

confidence: 99%

Thyroid Carcinoma: Is Postoperative External Irradiation Indicated?

Kagan¹,

Nussbaum²,

Chan³

et al. 1974

Oncology

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A review of 76 patients with thyroid carcinoma, in which residual disease was left behind, has been presented. Of the 76 patients, 29 received postoperative irradiation, and 47 received no postoperative irradiation. The median survival for the group receiving postoperative irradiation was 16 years. In the 47 patients with thyroid carcinoma who received no postoperative irradiation, the median survival was 9 years. The treatment of thyroid carcinoma is basically surgical in nature. Patientswith evidence of infiltrative residual disease following surgery may benefit from postoperative irradiation.

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The Results of X-Ray Treatment in Undifferentiated Carcinoma of the Thyroid

Cited by 26 publications

References 2 publications

Combined Chemotherapy and Radiation Therapy in Spindle and Giant Cell Carcinoma of the Thyroid Gland: Report of a case

Combined Chemotherapy and Radiation Therapy in Spindle and Giant Cell Carcinoma of the Thyroid Gland: Report of a case

Anaplastic carcinoma of the thyroid.A review of 84 cases of spindle and giant cell carcinoma of the thyroid

Thyroid Carcinoma: Is Postoperative External Irradiation Indicated?

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