The resveratrol derivatives trans-3,5-dimethoxy-4-fluoro-4′-hydroxystilbene and trans-2,4′,5-trihydroxystilbene decrease oxidative stress and prolong lifespan in <i>Caenorhabditis elegans</i>

Fischer, Nadine; Büchter, Christian; Koch, Karoline; Albert, Sabrina; Csük, René; Wätjen, Wim

doi:10.1111/jphp.12657

Cited by 30 publications

(28 citation statements)

References 23 publications

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“…9d). Our results were consistent with previous studies which reported that resveratrol acts against oxidative stress by regulating cytochromes involved in the metabolism of exogenous substances [41]. Taken together, we speculated that the repair effect of resveratrol on damage due to high sucrose-stearic acid is mainly manifested in two aspects: one is to reduce the oxidative stress of cells and the other is to participate in the metabolism of exogenous substances (Additional files 2, 3, 4, and 5).…”

Section: Resveratrol Protects Sugar and Lipid Damage To Nematodessupporting

confidence: 92%

Effects of excess sugars and lipids on the growth and development of Caenorhabditis elegans

Wang

Zhang

et al. 2020

Genes Nutr

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Background: Excessive intake of carbohydrates and fats causes over-nutrition, leading to a variety of diseases and complications. Here, we characterized the effects of different types of sugar and lipids on the growth and development of Caenorhabditis elegans. Methods: We measured the lifespan, reproductive capacity, and length of nematodes after sugars and lipids treatment alone and co-treatment of sugars and lipids. Furthermore, we studied the mechanisms underlying the damage caused by high-sucrose and high-stearic acid on C.elegans by using transcriptome sequencing technology. Results: The results showed that a certain concentration of sugar and lipid promoted the growth and development of nematodes. However, excessive sugars and lipids shortened the lifespan and length of nematodes and destroyed their reproductive capacity. Based on the results of the orthogonal test, we selected 400 mmol/L sucrose and 500 μg/mL stearic acid to model a high-sugar and high-lipid diet for C. elegans. Conclusion: High-sugar and high-lipid intake altered the expression of genes involved in biofilm synthesis, genes that catalyze the synthesis and degradation of endogenous substances, and genes involved in innate immunity, resulting in physiological damage. Furthermore, we explored the protective effect of resveratrol on high-sugar and high-lipid damage to nematodes. Resveratrol plays a role in repairing by participating in the metabolism of foreign substances and reducing cellular oxidative stress.

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Section: Resveratrol Protects Sugar and Lipid Damage To Nematodessupporting

confidence: 92%

Effects of excess sugars and lipids on the growth and development of Caenorhabditis elegans

Wang

Zhang

et al. 2020

Genes Nutr

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“…KEGG analysis showed that the repair of resveratrol may be related to the metabolism of cytochrome P450 to foreign substances and glutathione metabolism (Fig.4D). Our results were consistent with previous studies which reported that resveratrol acts against oxidative stress by regulating cytochromes involved in the metabolism of exogenous substances (F ischer et al . 2017).…”

Section: Discussionsupporting

confidence: 94%

Effects of sugars and lipids on the growth and development ofCaenorhabditis elegans

Xiong

Lin

Zhang

et al. 2019

Preprint

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18Excessive intake of carbohydrates and fats causes over-nutrition, leading to a variety of diseases and 19 complications. Here, we characterized the effects of different types of sugar and lipids on the 20 growth and development of Caenorhabditis elegans. We measured the lifespan, reproductive 21 capacity, and length of nematodes after sugars and lipids treatment alone and co-treatment of sugars 22 and lipids. Furthermore, by using transcriptome sequencing technology, we studied the mechanisms 23 underlying the damaged caused by high-sucrose and high-stearic acid on C. elegans. The results 24 showed that a certain concentration of sugar and lipid promoted the growth and development of 25 nematodes. However, excessive sugars and lipids shortened the lifespan and length of nematodes 26 and destroyed their reproductive capacity. Based on the results of the orthogonal test, we selected 27 400 mmol/L sucrose and 500 μg/mL stearic acid to model a high-sugar and high-lipid diet for C. 28 elegans. High-sugar and high-lipid intake altered the expression of genes involved in biofilm 29 synthesis, genes that catalyze the synthesis and degradation of endogenous substances, and genes 30 involved in innate immunity, resulting in physiological damage. 31 Introduction 32 All animals require energy to sustain basic life activities, such as survival, growth, and 33 reproduction. Digested and absorbed, dietary nutrients are important precursors for the synthesis 34 and metabolism of cells. Carbohydrates and fats are the main organic material sources to sustain life 35 activities. Carbohydrates are present in all living organisms and have a variety of basic functions, 36providing energy for all non-photosynthetic organisms. Lipids perform many essential functions in 37 cells. Due to their highly reduced state, they are effective energy storage molecules. They are 38 bilayered hydrophobic units that form cells and organelle membranes, and act as effective signaling 39 molecules to facilitate communication between cells (SATOUCHI et al. 1993). Reasonable 40 2 carbohydrate and fat intake has a positive impact on human life activities, but excessive intake may 41 be harmful to the human body, leading to diabetes, high blood pressure, and tumors. In recent years, 42 with the prevalence of human obesity and diabetes, interest in lipid and carbohydrate metabolism 43 has become increasingly prominent. 44With the improvement in people's living standards, the dietary structure has gradually developed 45 towards high sugar and high lipid. Continued high sugar and high lipid intake can lead to several 46 abnormal conditions, such as obesity and type 2 diabetes. High fat and high lipid intake lead to 47 over-nutrition, which, in turn, causes obesity. In the past 40 years, the world's obese population has 48 increased from 105 million in 1975 to 641 million in 2014. Almost one in every 8 adults in the 49 world has obesity problems; China is a country with the greatest number of obese people (ASHRAFI 50 2007). Obesity increases the risk ...

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“…For instance, the garlic-derived thioallyl compounds S-allyl cysteine and S-allylmercaptocysteine have been shown to reduce ROS accumulation and increase C. elegans lifespan [ 17 ]. Similarly, treatment of C. elegans with four synthetic stilbene derivatives extended longevity by reducing ROS accumulation and oxidative stress [ 18 ].…”

Section: The Free Radical Theory Of Aging and Beyondmentioning

confidence: 99%

“…Moreover, respiration inhibition appears to activate the hypoxia-inducible factor-1 (HIF-1) by elevating ROS levels. This activation has been shown to increase longevity [ 17 , 18 ]. Studies in genetically modified mice have shown that a moderately impaired mitochondrial function can result in healthier aging, whereas severely altered mitochondrial homeostasis can be detrimental [ 39 , 40 ].…”

Section: The Free Radical Theory Of Aging and Beyondmentioning

confidence: 99%

The Good, the Bad, and the Ugly of ROS: New Insights on Aging and Aging‐Related Diseases from Eukaryotic and Prokaryotic Model Organisms

Santos

Sinha

Lindner

2018

Oxidative Medicine and Cellular Longevity

127

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Aging is associated with the accumulation of cellular damage over the course of a lifetime. This process is promoted in large part by reactive oxygen species (ROS) generated via cellular metabolic and respiratory pathways. Pharmacological, nonpharmacological, and genetic interventions have been used to target cellular and mitochondrial networks in an effort to decipher aging and age-related disorders. While ROS historically have been viewed as a detrimental byproduct of normal metabolism and associated with several pathologies, recent research has revealed a more complex and beneficial role of ROS in regulating metabolism, development, and lifespan. In this review, we summarize the recent advances in ROS research, focusing on both the beneficial and harmful roles of ROS, many of which are conserved across species from bacteria to humans, in various aspects of cellular physiology. These studies provide a new context for our understanding of the parts ROS play in health and disease. Moreover, we highlight the utility of bacterial models to elucidate the molecular pathways by which ROS mediate aging and aging-related diseases.

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The resveratrol derivatives trans-3,5-dimethoxy-4-fluoro-4′-hydroxystilbene and trans-2,4′,5-trihydroxystilbene decrease oxidative stress and prolong lifespan in Caenorhabditis elegans

Abstract: In contrast to resveratrol, the synthetic stilbene derivatives (3) and (6) increase the lifespan of C. elegans, rendering them promising candidates for pharmacological anti-ageing purposes.

Cited by 30 publications

References 23 publications

Effects of excess sugars and lipids on the growth and development of Caenorhabditis elegans

Effects of excess sugars and lipids on the growth and development of Caenorhabditis elegans

Effects of sugars and lipids on the growth and development ofCaenorhabditis elegans

The Good, the Bad, and the Ugly of ROS: New Insights on Aging and Aging‐Related Diseases from Eukaryotic and Prokaryotic Model Organisms

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