The retinofugal and retinopetal systems inLampetra fluviatilis an experimental study using radioautographic and HRP methods

Vesselkin, N. P.; Ermakova, T.V.; Repérant, J; Kosareva, A. A.; Кенигфест, Н. Б.

doi:10.1016/0006-8993(80)90079-7

Cited by 116 publications

(51 citation statements)

References 16 publications

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“…In lampreys this pathway has been extensively studied in larval, transforming and adult animals [Northcutt and Przybylski, 1973;Kennedy and Rubinson, 1977;Kosareva et al, 1977;Kosareva, 1980;Repérant et al, 1980;Vesselkin et al, 1980Vesselkin et al, , 1984De Miguel et al, 1990]. Our results confirm the existence of two optic tracts that can be easily followed to their end in the superficial layers of the OT.…”

Section: Afferents From the Retinasupporting

confidence: 78%

“…Following application of biocytin in the eye bulb, both retinofugal and retinopetal connections were revealed, as previously reported by using other techniques [Kennedy and Rubinson, 1977;Kosareva, 1980;Repérant et al, 1980Repérant et al, , 1982Vesselkin et al, 1980Vesselkin et al, , 1984Vesselkin et al, , 1996Vesselkin and Repérant, 1985;De Miguel et al, 1990;Rodicio et al, 1995]. Briefly, retinofugal fibers of the optic tract projected mostly to the superficial layers of the contralateral OT (SM and SO) and constituted the lateral and axial optic tracts, whereas the retinopetal cells distributed in the M5 nucleus of Schöber and the mesencephalic reticular area ( fig.…”

Section: Complementary Experimentssupporting

confidence: 49%

“…Retinal projections in larval, transforming, and adult lampreys have been the matter of numerous experimental studies [Northcutt and Przybylski, 1973;Kennedy and Rubinson, 1977;Kosareva et al, 1977;Kosareva, 1980;Repérant et al, 1980;Vesselkin et al, 1980Vesselkin et al, , 1984De Miguel et al, 1990]. Data presented by these authors demonstrated the presence of a major contralateral retinal projection to the OT, but also a small ipsilateral projection.…”

Section: Introductionmentioning

confidence: 74%

“…Some large dorsal dendrites coursed in the OT, where some cell bodies could also be observed. The M5 nucleus of Schöber and the mesencephalic reticular area are two well-known retinopetal nuclei in lampreys [Kosareva, 1980;Repérant et al, 1980Repérant et al, , 1982Vesselkin et al, 1980Vesselkin et al, , 1984Vesselkin et al, , 1996Vesselkin and Repérant, 1985;Rodicio et al, 1995]. These studies showed that the retinopetal cells send their axons rostrally through the axial optic tract on the way to the retina and have long dendrites that can reach the OT.…”

Section: Afferent Connections Of the Adult Lamprey Otmentioning

confidence: 99%

“…In addition to the OT, the retinofugal tracts also contribute to prethalamic, thalamic and pretectal terminal fields [Kennedy and Rubinson, 1977;Vesselkin et al, 1980;De Miguel et al, 1990]. Three radial layers can be distinguished in these diencephalic regions: a periventricular layer that is densely packed with cell bodies, an intermediate layer with migrated cells, and a superficial layer that mostly contains neuropil and fiber tracts [Pombal and Puelles, 1999].…”

Section: Diencephalic Projectionsmentioning

confidence: 99%

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Afferent Connections of the Optic Tectum in Lampreys: An Experimental Study

Arriba

Pombal²

2006

Brain Behav Evol

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Tectal afferents were studied in adult lampreys of three species (Ichthyomyzon unicuspis, Lampetra fluviatilis, and Petromyzon marinus) following unilateral BDA injections into the optic tectum (OT). In the secondary prosencephalon, neurons projecting to the OT were observed in the pallium, the subhipoccampal lobe, the striatum, the preoptic area and the hypothalamus. Following tectal injections, backfilled diencephalic cells were found bilaterally in: prethalamic eminence, ventral geniculate nucleus, periventricular prethalamic nucleus, periventricular pretectal nucleus, precommissural nucleus, magnocellular and parvocellular nuclei of the posterior commissure and pretectal nucleus; and ipsilaterally in: nucleus of Bellonci, periventricular thalamic nucleus, nucleus of the tuberculum posterior, and the subpretectal tegmentum, as well as in the pineal organ. At midbrain levels, retrogradely labeled cells were seen in the ipsilateral torus semicircularis, the contralateral OT, and bilaterally in the mesencephalic reticular formation and inside the limits of the retinopetal nuclei. In the hindbrain, tectal projecting cells were also bilaterally labeled in the dorsal and lateral isthmic nuclei, the octavolateral area, the sensory nucleus of the descending trigeminal tract, the dorsal column nucleus and the reticular formation. The rostral spinal cord also exhibited a few labeled cells. These results demonstrate a complex pattern of connections in the lamprey OT, most of which have been reported in other vertebrates. Hence, the lamprey OT receives a large number of nonvisual afferents from all major brain areas, and so is involved in information processing from different somatic sensory modalities.

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Section: Afferents From the Retinasupporting

confidence: 78%

Section: Complementary Experimentssupporting

confidence: 49%

Section: Introductionmentioning

confidence: 74%

Section: Afferent Connections Of the Adult Lamprey Otmentioning

confidence: 99%

Section: Diencephalic Projectionsmentioning

confidence: 99%

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Afferent Connections of the Optic Tectum in Lampreys: An Experimental Study

Arriba

Pombal²

2006

Brain Behav Evol

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Afferents of the lamprey striatum with special reference to the dopaminergic system: A combined tracing and immunohistochemical study

1997

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The origin of afferents to the striatum in lamprey (Lampetra fluviatilis) was studied by using fluorescein-coupled dextran-amines (FDA). Injection of FDA into the striatum retrogradely labeled several cell populations in the forebrain and the rostral rhombencephalon. No retrograde labeled cells were seen in the mesencephalon. A dopamine-specific antiserum was used to determined the distribution of dopaminergic perikarya and fibers. Many dopamine-immunoreactive (DA-ir) fibers were present throughout the brain, but the highest density of labeled fibers was in the mediobasal prosencephalon, especially in the striatum, the lateral hypothalamic area, and the neurohypophysis. Most DA-ir cells were located in the mediobasal diencephalon (preoptic region, nucleus commissurae postopticae, hypothalamus, and nucleus tuberculi posterioris). In the mesencephalon, only a few immunopositive cells were observed in the tectum opticum. In the rhombencephalon, DA-ir cells were observed in the isthmic region, dorsally to the descending trigeminal tract, and caudally to the posterior rhombencephalic reticular nucleus. The rostralmost spinal cord received many descending DA-ir fibers from the brainstem. Along the spinal cord, DA-ir neurons were also found, some of which projected to the medioventral surface, forming a prominent plexus. On the basis of double-labeling experiments, it is shown that the dopaminergic input to the striatum originates from the nucleus tuberculi posterioris. Thus, the striatum receives inputs from different structures, including a strong dopaminergic innervation from the diencephalon. Much of the dopaminergic system in Lampetra fluviatilis is basically similar to that seen in some teleosts, but it presents differences with other anamniote (elasmobranch) as well as amniote groups.

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Diencephalic projection to reticulospinal neurons involved in the initiation of locomotion in adult lampreysLampetra fluviatilis

1997

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Morphological and electrophysiological techniques were used to characterize a diencephalic projection from the ventral thalamus to reticulospinal neurons and its role in initiating rhythmic locomotor activity in the spinal cord of adult lampreys (Lampetra fluviatilis). Injection of fluorescein-coupled dextran amine (FDA) into the rhombencephalic reticular nuclei labeled neurons in the ventral thalamus region on both the ipsilateral side and the contralateral side. Injection of FDA into the ventral thalamus labeled axonal projections in all reticular nuclei, but no direct projections were found to the spinal cord. Extracellular stimulation of the ventral thalamus elicited monosynaptic excitatory postsynaptic potentials (EPSPs), polysynaptic EPSPs, and inhibitory postsynaptic potentials (IPSPs) in reticulospinal neurons in the posterior (prrn) and middle (mrrn) rhombencephalic reticular nuclei. The monosynaptic EPSPs were blocked by the glutamate antagonist kynurenic acid and can be considered glutamatergic. The monosynaptic EPSPs were potentiated (up to 12 minutes) following a brief high-frequency stimulation. Stimulation of the ventral thalamus induced rhythmic firing of reticulospinal neurons and elicited rhythmic burst activity in the spinal ventral roots. The projections from the ventral thalamus to the reticulospinal neurons in the prrn and mrrn thus provide excitatory inputs to the reticulospinal neurons, which, in turn, can activate the spinal circuits underlying locomotion. Also, the input nuclei to the ventral thalamus were labeled following injection of FDA into this nucleus. Labeled cells were found in the olfactory bulb, pallial areas, striatum, preoptic nucleus, hypothalamus, dorsal thalamus, optic tectum, and dorsal isthmic gray. The ventral thalamus, therefore, receives inputs from several different regions in the brain and controls the level of excitability in reticulospinal neurons.

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The retinofugal and retinopetal systems inLampetra fluviatilis an experimental study using radioautographic and HRP methods

Cited by 116 publications

References 16 publications

Afferent Connections of the Optic Tectum in Lampreys: An Experimental Study

Afferent Connections of the Optic Tectum in Lampreys: An Experimental Study

Afferents of the lamprey striatum with special reference to the dopaminergic system: A combined tracing and immunohistochemical study

Diencephalic projection to reticulospinal neurons involved in the initiation of locomotion in adult lampreysLampetra fluviatilis

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