The rewarding effects of alcohol after bariatric surgery: do they change and are they associated with pharmacokinetic changes?

Engel, Scott G.; Schaefer, Lauren M.; Kerver, Gail A.; Leone, Lynnette; Smith, Greg; Mitchell, James E.; Gunstad, John; Crosby, Ross D.; Steffen, Kristine J.

doi:10.1016/j.soard.2021.08.011

Cited by 11 publications

(12 citation statements)

References 23 publications

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“…Corresponding observed and modeled data with 95% CI are reported in eTable 1, Supplemental Digital Content 1, http://links.lww.com/SLA/E339. The prevalence of elevated AUDIT-C score, symptoms of alcoholrelated harm, and alcohol-related problems significantly increased from 3% (95% CI,1-6), 2% (95% CI,0-3), and 2% (95% CI,0-3), respectively, 6 months postoperatively to 25% (95% CI, [19][20][21][22][23][24][25][26][27][28][29][30][31], 16% (95% CI,10-22), and 19% (95% CI,13-25), respectively, 8 years postoperatively. eTable 7, Supplemental Digital Content 1, http://links.…”

Section: Resultsmentioning

confidence: 99%

“…In addition to the changes in alcohol pharmacokinetics, alcohol sensitivity also changes postoperatively. For example, women up to 5 years post-RYGB or VSG experience fewer alcohol-related sedative effects than controls, 29 and adults 1-year post-RYGB report greater rewarding effects of alcohol than preoperatively 30 . To our knowledge, there are no studies examining the pharmacokinetics or rewarding properties of alcohol in individuals who undergo MBS as adolescents.…”

Section: Discussionmentioning

confidence: 99%

“…For example, women up to 5 years post-RYGB or VSG experience fewer alcohol-related sedative effects than controls, 29 and adults 1-year post-RYGB report greater rewarding effects of alcohol than preoperatively. 30 To our knowledge, there are no studies examining the pharmacokinetics or rewarding properties of alcohol in individuals who undergo MBS as adolescents. However, animal studies suggest that All 4 models adjusted for clinical site because it was related to missing followup data and age.…”

Section: Discussionmentioning

confidence: 99%

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A Prospective Cohort of Alcohol Use and Alcohol-related Problems Before and After Metabolic and Bariatric Surgery in Adolescents

et al. 2022

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Objective: To describe alcohol use, alcohol-related harm, and alcohol-related problems preoperatively and up to 8 years following metabolic and bariatric surgery (MBS) in adolescents. Background: Risk for alcohol use and alcohol use disorders (AUD) increases post-Roux-en-Y gastric bypass and vertical sleeve gastrectomy in adults. However, data are lacking in adolescents who undergo MBS. Methods: This study includes 217 adolescents (aged 13–19 y) enrolled in a 5-center prospective cohort study who underwent Roux-en-Y gastric bypass or vertical sleeve gastrectomy (2007–2011) and reported alcohol use preoperatively and annually postoperatively for up to 8 years. Time to elevated Alcohol Use Disorder Identification Test-Consumption (AUDIT-C) score, alcohol-related harm, and alcohol-related problems were analyzed with Kaplan-Meier estimates of cumulative incidence. Results: Preoperatively, the median age was 17 years; the median body mass index was 51 kg/m2. Alcohol use frequency and average quantity of drinks per drinking day increased postoperatively (2% consumed alcohol 2–4 times/month 6 months versus 24% 8 years postoperatively, P<0.001; 2% consumed≥3 drinks per drinking day 6 months versus 35% 8 years postoperatively, P<0.001). Cumulative incidence of postoperative onset elevated AUDIT-C score, alcohol-related harm, and alcohol-related problems at year 8 were 45% (95% CI:37–53), 43% (95% CI:36–51), and 47% (95% CI:40–55), respectively. Conclusions: Nearly half of those who underwent MBS as adolescents screened positively for AUD, symptoms of alcohol-related harm, or alcohol-related problems 8 years post-MBS, highlighting the risk for alcohol use and AUD after MBS in adolescents. AUD evaluation and treatment should be integrated into routine long-term care for adolescents undergoing MBS.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A Prospective Cohort of Alcohol Use and Alcohol-related Problems Before and After Metabolic and Bariatric Surgery in Adolescents

et al. 2022

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“…Individuals who have had RYGB reach the peak alcohol level faster than people who have not, and this level is higher in these individuals. [46][47][48] Contradictory results have been reported…”

Section: Discussionmentioning

confidence: 97%

‘We're outside the norm again because of the thing that allowed us to be inside the norm’: An interpretative phenomenological analysis of the experience of developing an alcohol use disorder after bariatric surgery

Er,

Flahault,

Etienne

2023

Clinical Obesity

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SummaryStudies indicate that bariatric surgery is associated with an increased risk of alcohol use disorder (AUD). It is considered some patients develop the disorder after surgery, without having antecedents of preoperative alcohol problems. This qualitative study aimed to explore the experiences of people who developed AUD postoperatively and understand how they make sense of the onset of this disorder. A semi‐directed interview was carried out with eight adults who had undergone bariatric surgery and developed AUD de novo postoperatively. Data were analysed using interpretative phenomenological analysis. Four superordinate themes emerged: (1) ‘losing control over drinking and self after surgery’; (2) ‘feelings of guilt, shame and loss contrasted with perceptions of still being lucky’; (3) ‘trying to make sense of the onset of AUD’; and (4) ‘retrospective evaluation of bariatric surgery and preoperative information’. These themes indicated loss of control was a central aspect of participant's experiences of postoperative alcohol consumption. AUD was associated with negative emotions and cognitions, but several participants still considered themselves lucky. All tried to make sense of this disorder's onset; many felt they would not have developed AUD if they had not undergone surgery. The onset of AUD influenced their current perceptions and feelings about surgery and the preoperative information regarding AUD risks. Taken together, these results provide insight into the subjective experience of suffering from new‐onset AUD post‐surgery. However, more studies are necessary to gain a better understanding of the physical and psychological implications of postoperative AUD.

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“…Endret anatomi e er operasjonen gir kraftigere og raskere alkoholeffekt på grunn av redusert nedbrytning av alkohol og raskere tømming av magesekken, saerlig ved gastrisk bypass (10,11). En nylig publisert studie av Engel og medarbeidere (12) med målinger før kirurgi og e år e er identifiserte endringer i belønningseffekter og farmakokinetiske effekter av alkohol som mulige årsaker til økt risiko for alkoholbrukslidelse e er gastrisk bypass. Forsterkede belønningsreaksjoner ved alkoholinntak kan skje uavhengig av endret farmakokinetikk, muligens mediert av endringer i appeti regulerende peptider i magesekken (11).…”

Section: H Ov E D F U N Nunclassified

Problematic alcohol use in post-bariatric patients – a qualitative study

Tvedt¹,

Stokke²,

Lid³

et al. 2023

Tidsskriftet

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Regionalt kompetansesenter for rusmiddelforskning i Helse-Vest Stavanger universitetssjukehus Forfa erbidrag: planlegging, deltakelse og gjennomføring av forskningsprosessen, intervju av deltakerne, utforming/design, datainnsamling, analyse, fortolkning, li eratursøk og utarbeiding av manuskriptet. Hege Tvedt er klinisk sosionom med master i rus-og psykisk helsearbeid og utfører rustilsyn på somatiske sengeposter. Forfa eren har fylt ut ICMJE-skjemaet og oppgir ingen interessekonflikter.Rogaland A-senter Forfa erbidrag: idé, rekru ering av deltakerne, rusmedisinsk kvalitetssikring, analyse og tolkning av data, li eratursøk, utredning/revisjon av manuskriptet og godkjenning av innsendte versjon. Reidar Stokke er spesialist i rus-og avhengighetsmedisin og i allmennmedisin og er avdelingssjef. Forfa eren har fylt ut ICMJE-skjemaet og oppgir ingen interessekonflikter.Regionalt kompetansesenter for rusmiddelforskning i Helse-Vest Stavanger universitetssjukehus og Det helsevitenskapelige fakultet Universitetet i Stavanger Forfa erbidrag: idé, tilre elegging, li eratursøk, revisjon av manuset og godkjenning av innsendte versjon. Torgeir Gilje Lid er ph.d., spesialist i allmennmedisin, forskningsleder og førsteamanuensis II. Forfa eren har fylt ut ICMJE-skjemaet og oppgir ingen interessekonflikter. Det helsevitenskapelige fakultet Universitetet i Stavanger ogRogaland A-senter Forfa erbidrag: idé, utforming, design, metode, analyse og tolkning, li eratursøk, utarbeiding og revisjon av manuskriptet samt godkjenning av innsendte versjon. Anne Schanche Selbekk er ph.d., sosiolog, førsteamanuensis og tidligere ansa som FOU-leder ved Rogaland A-senter. Forfa eren har fylt ut ICMJE-skjemaet og oppgir ingen interessekonflikter.Problematisk alkoholbruk e er fedmekirurgi -en kvalitativ studie | Tidsskrift for Den norske legeforening

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The rewarding effects of alcohol after bariatric surgery: do they change and are they associated with pharmacokinetic changes?

Cited by 11 publications

References 23 publications

A Prospective Cohort of Alcohol Use and Alcohol-related Problems Before and After Metabolic and Bariatric Surgery in Adolescents

A Prospective Cohort of Alcohol Use and Alcohol-related Problems Before and After Metabolic and Bariatric Surgery in Adolescents

‘We're outside the norm again because of the thing that allowed us to be inside the norm’: An interpretative phenomenological analysis of the experience of developing an alcohol use disorder after bariatric surgery

Problematic alcohol use in post-bariatric patients – a qualitative study

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