The rheological properties of blood and the risk of cardiovascular disease in patients with obstructive sleep apnea syndrome (OSAS)

Tażbirek, Maciej; Słowińska, Ludmiła; Kawalski, Marcin; Pierzchała, Władysław

doi:10.5603/fhc.2011.0028

Cited by 7 publications

(4 citation statements)

References 23 publications

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“…Although the hematocrit effect was ruled out, the blood viscosities of both current and former smokers were still higher than the non-smoking group [8]. This finding suggests that BV may be emphasized as a risk factor [1, 16, 26, 27, 30–32]. Our results are consistent with previous relevant studies.…”

Section: Discussionsupporting

confidence: 90%

Blood viscosity as a forgotten factor and its effect on pulmonary flow

et al. 2013

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Section: Discussionsupporting

confidence: 90%

Blood viscosity as a forgotten factor and its effect on pulmonary flow

et al. 2013

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“…In OSAS subjects, increased platelet activation and aggregation have been observed, especially during the nocturnal hours [73,74]. This activated platelet phenotype was correlated with the increased sympathetic tone and the consequent elevated values of circulating catecholamines [75]. Other authours found an overexpression of P-selectin on platelet surfaces, influenced by OSAS severity [73].…”

Section: Blood Coagulation and Hemorheological Abnormalitiesmentioning

confidence: 99%

Obstructive Sleep Apnea Syndrome: Links Betwen Pathophysiology and Cardiovascular Complications

Hopps¹,

Caimi²

2015

CIM

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Purpose: The prevalence of obstructive sleep apnea syndrome (OSAS) is increasing, especially in the middle-aged population. OSAS is associated with an elevated risk of cardiovascular morbidity and mortality. Arterial hypertension is often the first consequence of OSAS, but the most severe complications are coronary artery disease, stroke and arrhythmias. The aim of this review was to analyze the several mechanisms involved in the development of the cardiovascular events, such as endothelial dysfunction accompanied by a pro-inflammatory and pro-oxidant status, hemorheological alterations, hypercoagulability and imbalance between matrix metalloproteases and their inhibitors. Source: A search on PubMed was carried out using the following terms: obstructive sleep apnea syndrome; endothelial dysfunction; oxidative stress; inflammation; rheology; matrix metalloproteases. Principal findings: OSAS severity strongly influenced cardiovascular risk factors and, furthermore, it was correlated with the incidence of fatal and non-fatal events. Conclusions: The treatment with continuous positive airways pressure (cPAP) is the gold standard for OSAS and was able to positively influence all the pathophysiological mechanisms responsible for cardiovascular diseases. Long-term cPAP improved endothelial function and hemorheology, reduced oxidative stress and inflammation, and decreased the levels of metalloproteases.

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“…In OSAS, an impaired autonomic nervous system activity has been demonstrated: during apneas and hypopneas an enhanced parasympathetic tone is evident, while sympathetic nervous system tone increases after the apneic events [20]. In addition, several papers have demonstrated an impaired hemorheological profile [12,41,42], an increased blood coagulation [43] and also an altered inflammatory [13,19,34] and oxidative status [2,3,7,10,26,35,40] in OSAS subjects. The frequent hypoxia-reoxygenation episodes are presumed to play a key role in the pathogenesis of endothelial dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Nitric oxide metabolites and erythrocyte deformability in a group of subjects with obstructive sleep apnea syndrome

Canino

Hopps

Calandrino

et al. 2015

Clinical Hemorheology and Microcirculation

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Our aim was to evaluate nitric oxide metabolites (nitrite and nitrate), expressed as NOx, and erythrocyte deformability, expressed as elongation index, in a group of subjects with obstructive sleep apnea syndrome (OSAS). We enrolled 48 subjects (36 men and 12 women; mean age 50.3 ± 14.68 yrs) with OSAS diagnosed after a 1-night cardiorespiratory sleep study. OSAS severity was assessed evaluating the apnea/hypopnea index (AHI) and subjects were subdivided in two subgroups: Low (L = AHI <30) and High (H = AHI >30). NOx was examined converting nitrate into nitrite with a nitrate reductase and then assessing nitrite with spectrophotometry after the addition of Griess reagent. The elongation index was obtained using the diffractometer Rheodyn SSD of Myrenne at shear stresses of 30 and 60 Pa and it was expressed as elongation index (EI). We found no difference in NOx among the entire group of OSAS subjects and normal controls, while we observed a NOx decrease in the H subgroup in comparison with L subgroup, but not in comparison with normal controls. We noted a significant decrease in EI at each shear stress in the entire group and also in the two subgroups in comparison with controls. The decrease in NO bioavailability and in erythrocyte deformability might contribute to explain the increased cardiovascular risk in OSAS subjects.

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The rheological properties of blood and the risk of cardiovascular disease in patients with obstructive sleep apnea syndrome (OSAS)

Cited by 7 publications

References 23 publications

Blood viscosity as a forgotten factor and its effect on pulmonary flow

Blood viscosity as a forgotten factor and its effect on pulmonary flow

Obstructive Sleep Apnea Syndrome: Links Betwen Pathophysiology and Cardiovascular Complications

Nitric oxide metabolites and erythrocyte deformability in a group of subjects with obstructive sleep apnea syndrome

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