The right dorsal anterior cingulate cortex may play a role in anxiety disorder and visual function

Shinoura, Nobusada; Yamada, Ryuzo; Tabei, Yusuke; Shiode, Taketo; Itoi, Chihiro; Saito, Seiko; Midorikawa, Akira

doi:10.1179/1743132812y.0000000101

Cited by 15 publications

(11 citation statements)

References 34 publications

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“…Functional studies showed that the ACC processes amongst others emotion ( Kawamoto et al, 2012 , Killgore and Yurgelun-Todd, 2007 ), attention ( Nebel et al, 2005 ), and pain ( Büchel et al, 2002 , Lloyd et al, 2004 ). Changes in the ACC have been reported in cases of pain-induced depression ( Barthas et al, 2014 ) and anxiety disorder ( Shinoura et al, 2013 ). Patients with FSS experience alterations of attention, anticipation, and pain memories that correlate with increased activity of the ACC.…”

Section: Discussionmentioning

confidence: 99%

Neural correlates of somatoform disorders from a meta-analytic perspective on neuroimaging studies

Boeckle

Schrimpf

Liegl

et al. 2016

NeuroImage: Clinical

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Somatoform disorders (SD) are common medical disorders with prevalence rates between 3.5% and 18.4%, depending on country and medical setting. SD as outlined in the ICD-10 exhibits various biological, social, and psychological pathogenic factors. Little is known about the neural correlates of SD. The aims of this meta-analysis are to identify neuronal areas that are involved in SD and consistently differ between patients and healthy controls. We conducted a systematic literature research on neuroimaging studies of SD. Ten out of 686 studies fulfilled the inclusion criteria and were analyzed using activation likelihood estimation. Five neuronal areas differ between patients with SD and healthy controls namely the premotor and supplementary motor cortexes, the middle frontal gyrus, the anterior cingulate cortex, the insula, and the posterior cingulate cortex. These areas seem to have a particular importance for the occurrence of SD. Out of the ten studies two did not contribute to any of the clusters. Our results seem to largely overlap with the circuit network model of somatosensory amplification for SD. It is conceivable that functional disorders, independent of the clinical impression, show similar neurobiological processes. While overlaps do occur it is necessary to understand single functional somatic syndromes and their aetiology for future research, terminology, and treatment guidelines.

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Section: Discussionmentioning

confidence: 99%

Neural correlates of somatoform disorders from a meta-analytic perspective on neuroimaging studies

Boeckle

Schrimpf

Liegl

et al. 2016

NeuroImage: Clinical

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“…The cingulate cortex, as a part of the limbic cortex, has many functions, such as pain, 30 depression, 31 and anxiety disorder. 32 Yan et al 14 found that WM volumes were decreased in the right cingulate gyrus in patients with adult strabismus. In our study, we observed that the MD values were significantly increased in the brain regions of the left anterior cingulate in patients with comitant strabismus, which suggested abnormal microstructural changes in the left anterior cingulate.…”

Section: Discussionmentioning

confidence: 99%

Microstructural changes of whole brain in patients with comitant strabismus: evidence from a diffusion tensor imaging study

Huang¹,

Li²,

Zhang³

et al. 2016

NDT

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ObjectiveThe aim of this study was to investigate the fractional anisotropy (FA) and mean diffusivity (MD) using a diffusion tensor imaging technique and whole-brain voxel-based analysis in patients with comitant strabismus.Patients and methodsA total of 19 (nine males and ten females) patients with comitant strabismus and 19 age-, sex-, and education-matched healthy controls (HCs) underwent magnetic resonance imaging examination. Imaging data were analyzed using two-sample t-tests to identify group differences in FA and MD values. Patients with comitant strabismus were distinguishable from HCs by receiver operating characteristic curves.ResultsCompared with HCs, patients with comitant strabismus exhibited significantly decreased FA values in the brain regions of the left superior temporal gyrus and increased values in the bilateral medial frontal gyrus, right globus pallidus/brainstem, and bilateral precuneus. Meanwhile, MD value was significantly reduced in the brain regions of the bilateral cerebellum posterior lobe and left middle frontal gyrus but increased in the brain regions of the right middle frontal gyrus and left anterior cingulate.ConclusionThese results suggest significant brain abnormalities in comitant strabismus, which may underlie the pathologic mechanisms of fusion defects and ocular motility disorders in patients with comitant strabismus.

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“…It is connected with the prefrontal cortex, the parietal cortex, the motor system and the frontal eye fields, and modulates the frontal eye field, visual attention particularly during the tracking of visible targets [34]; it is also involved in the categorical recognition of visual objects [35]. Clinically, when the right dorsal ACC is invaded by a mass, such as a tumor, visual function deficits occur; once the tumor is removed, visual attention and visual memory improves [36]. The frontal lobe helps in the optic localization, coordinating multiple retinal fields and determining the fixation point.…”

Section: Discussionmentioning

confidence: 99%

Altered Spontaneous Brain Activity in Primary Open Angle Glaucoma: A Resting-State Functional Magnetic Resonance Imaging Study

Song

Wang

et al. 2014

PLoS ONE

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BackgroundPrevious studies demonstrated that primary open angle glaucoma (POAG) is associated with abnormal brain structure; however, little is known about the changes in the local synchronization of spontaneous activity. The main objective of this study was to investigate spontaneous brain activity in patients with POAG using regional homogeneity (ReHo) analysis based on resting state functional magnetic resonance imaging (rs-fMRI).Methodology/Principal FindingsThirty-nine POAG patients and forty-one age- and gender- matched healthy controls were finally included in the study. ReHo values were used to evaluate spontaneous brain activity and whole brain voxel-wise analysis of ReHo was carried out to detect differences by region in spontaneous brain activity between groups. Compared to controls, POAG patients showed increased ReHo in the right dorsal anterior cingulated cortex, the bilateral medial frontal gyrus and the right cerebellar anterior lobe, and decreased ReHo in the bilateral calcarine, bilateral precuneus gryus, bilateral pre/postcentral gyrus, left inferior parietal lobule and left cerebellum posterior lobe. A multiple linear regression analysis was performed to explore the relationships between clinical measures and ReHo by region showed significant group differences in the POAG group. Negative correlations were found between age and the ReHo values of the superior frontal gyrus (r = −0.323, p = 0.045), left calcarine (r = −0.357, p = 0.026) and inferior parietal lobule (r = −0.362, p = 0.024). A negative correlation was found between the ReHo values of the left precuneus and the cumulative mean defect (r = −0.400, p = 0.012).ConclusionsPOAG was associated with abnormal brain spontaneous activity in some brain regions and such changed regional activity may be associated with clinical parameters. Spontaneous brain activity may play a role in POAG initiation and progression.

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The right dorsal anterior cingulate cortex may play a role in anxiety disorder and visual function

Cited by 15 publications

References 34 publications

Neural correlates of somatoform disorders from a meta-analytic perspective on neuroimaging studies

Neural correlates of somatoform disorders from a meta-analytic perspective on neuroimaging studies

Microstructural changes of whole brain in patients with comitant strabismus: evidence from a diffusion tensor imaging study

Altered Spontaneous Brain Activity in Primary Open Angle Glaucoma: A Resting-State Functional Magnetic Resonance Imaging Study

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