The rise in incidence of lymphomas in Europe 1985–1992

Objectives. Non-Hodgkin Lymphomas (NHLs) are tumours of the lymphoid system which originate from lymph nodes or extranodal lymphatic tissue. Since they represent a heterogeneous group of diseases, it is very important to determine prognostic factors apart from staging and identification of the patients with poor prognosis. The objective of our study is to investigate clinical characteristics, treatments applied, and their outcomes, survival rates, and prognostic factors which may be effective on survival. Methods. Clinical characteristics, treatments applied, and their outcomes, survivals, and prognostic factors which may be effective on the survival in 230 patients who were diagnosed as NHL, and consulted to our center between the years 2002, and 2015 were retrospectively evaluated. Results. Median age of our patients (male, 54.8 %, and female, 45.2 %) was 57 years. The most frequently seen histopathological subtype was diffuse large β cell lymphoma. We have seen that IPI score, β symptom, levels of LDH, albumin, β2 microglobulin, and lymphocyte counts are significant prognostic factors. Stomach was the most frequently involved extranodal organ. Advanced stage, higher IPI score, extranodal organ involvement were found to be correlated with shorter survival times. Conclusion. Everyday developments occur in the diagnosis, classification, and treatment of NHL. Therefore, it is important for medical centres to evaluate their treatment outcomes, and prognostic factors affecting their survival rates.Eur Res J 2016;2(1):52-61

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“…Male dominancy rates differed among countries (USA, 1.43; Europe. 1.23: Austria, 1.52; Greece 1.16, and Korea, 1.6 [8][9][10][11][12].…”

Section: Discussionmentioning

confidence: 99%

Clinical and pathological evaluation of histopathological subtypes in patients with non-Hodgkin’s lymphoma

2016

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“…Concurrent increases in the prevalence of obesity and the incidence of NHL over the past few decades have contributed to the hypothesis that there is an association between obesity and NHL, 26,419,420 but findings from epidemiologic studies have been inconsistent. In a large prospective mortality study of more than 900,000 US adults, Calle et al 421 423 Other cohort and case-control studies reported significant positive associations with NHL risk among obese men (RR range: 1.2-1.6) 31,424,425 and women (RR range: 1.2-1.6), compared to normal-weight individuals.…”

Section: Body Mass Indexmentioning

confidence: 99%

The non-Hodgkin lymphomas: A review of the epidemiologic literature

et al. 2007

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“…In common with the North of England the SEER data indicated a trend for increasing incidence of cancers in the 15 to 19 year-olds. Those cancers for which the differences in incidence rates were greatest included tumours which have been reported to be increasing in incidence (testicular cancer, melanoma and NHL) (Brown et al, 1987;Elder, 1995;Cartwright et al, 1999). Different racial characteristics of the populations may also affect the incidence of some types of cancer.…”

Section: Young Adultsmentioning

confidence: 99%

Incidence and survival for cancer in children and young adults in the North of England, 1968–1995: a report from the Northern Region Young Persons’ Malignant Disease Registry

et al. 2000

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The Northern Region Young Persons’ Malignant Disease Registry records information on young people under 25 years old diagnosed with cancer in the Northern Region of England. Incidence and survival rates were calculated for children and young adults diagnosed with cancer between 1968 and 1995. There were 2099 (M:F 1.28:1) children (age 0–14 years) and 2217 (M:F 1.23:1) young adults (15–24 years) diagnosed with a first cancer between 1968 and 1995. The age-standardized rate (ASR) for childhood cancer was 121 per million 0 to 14 year-olds per year. For young adults the ASR was 175 per million 15 to 24 year-olds, per year. Incidence of childhood cancer increased over time at a rate of 12 extra cases per million children, per decade ( P < 0.001). In young adults incidence rates increased by 16 extra cases per million 15 to 24 year-olds, per decade ( P < 0.001). For childhood cancer 5-year survival was 42% for those diagnosed 1968–1977, 57% for 1978–1987 and 71% (95% CI 67–75) for 1988–1995. Survival for young adults over the three periods was 45%, 62% and 73% (95% CI 70–78) respectively. The cumulative risk of developing cancer before the age of 25 is 1 in 285. Over the 28-year period there were significant improvements in survival and modest increases in incidence in both children and young adults. © 2000 Cancer Research Campaign

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The rise in incidence of lymphomas in Europe 1985–1992

Cited by 165 publications

References 19 publications

Clinical and pathological evaluation of histopathological subtypes in patients with non-Hodgkin’s lymphoma

Clinical and pathological evaluation of histopathological subtypes in patients with non-Hodgkin’s lymphoma

The non-Hodgkin lymphomas: A review of the epidemiologic literature

Incidence and survival for cancer in children and young adults in the North of England, 1968–1995: a report from the Northern Region Young Persons’ Malignant Disease Registry

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