The Rise of the OM-LoC: Opto-Microfluidic Enabled Lab-on-Chip

Dawson, Harry; Elias, Jinane; Etienne, Pascal; Calas-Etienne, Sylvie

doi:10.3390/mi12121467

Cited by 9 publications

(7 citation statements)

References 172 publications

(248 reference statements)

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“…Optical tweezers are classified as single-beam optical tweezers, holographic optical tweezers, optic-fiber optical tweezers, planar waveguide optical tweezers, photonic crystal optical tweezers, and plasma optical tweezers. [110][111][112] Single-beam optical tweezers can only capture and manipulate one particle at a time. While researchers generally seek to control multiple particles simultaneously and use multibeam coupling to generate multiple optical traps.…”

Section: Optical Field Methodsmentioning

confidence: 99%

A Review of Single‐Cell Pose Adjustment and Puncture

Guo

Zhang

Jin

et al. 2022

Advanced Intelligent Systems

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Single‐cell manipulation technology is an essential method of cell research, with wide applications in biological engineering, medical engineering, agricultural engineering, and other precise manipulation fields. Cell pose adjustment and cell puncture are considered as two basic operations of single‐cell manipulation. Cell pose adjustment can be used for cell sorting, cell trapping, cell orientation, cell transportation, etc. It consists of direct contact manipulation methods and noncontact manipulation methods (e.g., mechanical contact method, electric field, optical field, magnetic field, acoustic field, and hydrodynamic methods). Cell puncture consists of ordinary glass needle puncture methods, piezoelectric‐assisted puncture methods, and rotational oscillatory drill puncture methods. It aims to achieve directional and quantified injection or sampling with minimal damage. Herein, the recent research progress on single‐cell pose adjustment and puncture methods is systematically summarized and discussed, which involves the basic mechanism, characteristics, limitations, and applications. Some potential directions for future research are proposed in accordance with the above analysis. It is hoped that this review can provide a reference for academic research and industrial applications of single‐cell manipulation technology.

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Section: Optical Field Methodsmentioning

confidence: 99%

A Review of Single‐Cell Pose Adjustment and Puncture

Guo

Zhang

Jin

et al. 2022

Advanced Intelligent Systems

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“…Several LoC-based applications, as can be found in literature, do not need to treat the analyte [ 55 , 56 , 57 ] but simply perform the detection by using electrochemical [ 58 , 59 , 60 ], mechanical [ 61 ], or optical methods [ 21 , 62 , 63 , 64 ]. Among these, the optical detection has been the most widely used technique for quantitative analysis due to its robustness and sensitivity [ 2 ].…”

Section: Evaluation Of System Performancesmentioning

confidence: 99%

Thin-Film-Based Multifunctional System for Optical Detection and Thermal Treatment of Biological Samples

et al. 2022

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In this work, we present a multifunctional Lab-on-Chip (LoC) platform based on hydrogenated amorphous silicon sensors suitable for a wide range of application in the fields of biochemical and food quality control analysis. The proposed system includes a LoC fabricated on a 5 cm × 5 cm glass substrate and a set of electronic boards for controlling the LoC functionalities. The presented Lab-on-Chip comprises light and temperature sensors, a thin film resistor acting as a heating source, and an optional thin film interferential filter suitable for fluorescence analysis. The developed electronics allows to control the thin film heater, a light source for fluorescence and absorption measurements, and the photosensors to acquire luminescent signals. All these modules are enclosed in a black metal box ensuring the portability of the whole platform. System performances have been evaluated in terms of sensor optical performances and thermal control achievements. For optical sensors, we have found a minimum number of detectable photons of 8 × 104 s−1·cm−2: at room temperature, 1.6 × 106 s−1·cm−2: in presence of fluorescence excitation source, and 2.4 × 106 s−1·cm−2· at 90 °C. From a thermal management point of view, we have obtained heating and cooling rates both equal to 2.2 °C/s, and a temperature sensor sensitivity of about 3 mV/°C even in presence of light. The achieved performances demonstrate the possibility to simultaneously use all integrated sensors and actuators, making promising the presented platform for a wide range of application fields.

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“…Indeed, for carrying out this type of analysis performed using MoF devices, it is crucial to confine and transport the beam light coming from a light source towards the small volume of fluid circulating within micro-channels. In the end, properly acquiring the beam of light passing through the fluid makes it possible to collect useful non-specific information, such as its density, viscosity, velocity, and so on [ 12 ]. Therefore, to accomplish this purpose, the materials used for manufacturing this class of devices must have excellent optical properties to avoid issues such as high losses.…”

Section: Introductionmentioning

confidence: 99%

A Regression Approach to Model Refractive Index Measurements of Novel 3D Printable Photocurable Resins for Micro-Optofluidic Applications

Saitta,

Cutuli,

Celano

et al. 2023

Polymers

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In this work, a quadratic polynomial regression model was developed to aid practitioners in the determination of the refractive index value of transparent 3D printable photocurable resins usable for micro-optofluidic applications. The model was experimentally determined by correlating empirical optical transmission measurements (the dependent variable) to known refractive index values (the independent variable) of photocurable materials used in optics, thus obtaining a related regression equation. In detail, a novel, simple, and cost-effective experimental setup is proposed in this study for the first time for collecting the transmission measurements of smooth 3D printed samples (roughness ranging between 0.04 and 2 μm). The model was further used to determine the unknown refractive index value of novel photocurable resins applicable in vat photopolymerization (VP) 3D printing techniques for manufacturing micro-optofluidic (MoF) devices. In the end, this study proved how knowledge of this parameter allowed us to compare and interpret collected empirical optical data from microfluidic devices made of more traditional materials, i.e., Poly(dimethylsiloxane) (PDMS), up to novel 3D printable photocurable resins suitable for biological and biomedical applications. Thus, the developed model also provides a quick method to evaluate the suitability of novel 3D printable resins for MoF device fabrication within a well-defined range of refractive index values (1.56; 1.70).

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The Rise of the OM-LoC: Opto-Microfluidic Enabled Lab-on-Chip

Cited by 9 publications

References 172 publications

A Review of Single‐Cell Pose Adjustment and Puncture

A Review of Single‐Cell Pose Adjustment and Puncture

Thin-Film-Based Multifunctional System for Optical Detection and Thermal Treatment of Biological Samples

A Regression Approach to Model Refractive Index Measurements of Novel 3D Printable Photocurable Resins for Micro-Optofluidic Applications

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