The rise of transcutaneous drug delivery for the management of alopecia: a review of existing literature and an eye towards the future

Wipf, Angela; Boysen, Nicholas C.; Hordinsky, Maria; Dando, Emily; Sadick, Neil S.; Farah, Ronda S.

doi:10.1080/14764172.2018.1525743

Cited by 12 publications

(12 citation statements)

References 43 publications

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“…The symptoms of hair loss and thinning start as bitemporal recession at the frontal hairline, followed by diffuse thinning over the vertex of the scalp [ 2 ]. The standard treatment for this condition is either hair follicle transplantation or the stimulation of these follicles with topical or oral medication [ 3 , 4 , 5 , 6 ]. However, these methods are not proven to treat hair loss and can have problematic side effects and high costs [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth

Kwak

Kim

et al. 2020

Cells

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Conventional therapeutic applications of mesenchymal stromal cells (MSCs) focus on cell replacement and differentiation; however, increasing evidence suggests that most of their therapeutic effects are carried out by their various secretions. This study investigated the application of conditioned medium (CM) from human umbilical cord blood-derived MSCs (hUCB-MSCs) to improve hair growth and developed a method to reliably produce this optimized CM. Primed MSC-derived CM (P-CM) with combinations of TGF-β1 and LiCl was optimized by comparing its effects on the cell viability of dermal papilla cells (DPCs). P-CM significantly increased the viability of DPCs compared to CM. The secretion of vascular endothelial growth factor (VEGF) in DPCs was regulated by the macrophage migration inhibitory factor (MIF) in the P-CM secreted by MSCs. These findings suggest that P-CM can improve the efficacy in hair growth via a paracrine mechanism and that MIF in P-CM exerts hair growth-promoting effects via a VEGF-related β-catenin and p-GSK-3β [SER9] signaling pathway. Furthermore, clinical trials have shown that 5% P-CM improved androgenetic alopecia through producing an increased hair density, thickness, and growth rate, suggesting that this topical agent may be a novel and effective treatment option for patients with androgenetic alopecia.

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Section: Introductionmentioning

confidence: 99%

Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth

Kwak

Kim

et al. 2020

Cells

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“…Um tocante nesta temática que deve ser enfatizado, é que embora seja positivo os resultados atingidos até o momento, ainda são poucas as publicações e amostragens encontradas na literatura 37 .…”

Section: Avaliação Dos Resultadosunclassified

Estudo do padrão de melhora da alopecia androgenética em pacientes com uso de microagulhamento associado a minoxidil e/ou plasma rico em plaquetas e mesoterapia / Study of the pattern of improvement in androgenetic alopecia in patients using microneedling associated with minoxidil and/or platelet-rich plasma and mesotherapy

Ferreira

Rodrigues

2021

Arq Med Hosp Fac Cienc Med Santa Casa São Paulo

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Introdução: a alopécia ligada a fatores hormonais androgênicos é algo que há muito tempo tem sido alvo de estudos e aplicações de conhecimento científico em todo mundo. Este padrão de perda capilar, principalmente ligada ao sexo masculino dispõe de terapias que atualmente se limitam à interrupção da queda de fios com leve progressão de crescimento em alguns casos. Neste tocante, uma nova técnica de microagulhamento, com ou sem terapias adjuvantes, associado a métodos já consagradas como minoxidil tem levado o tratamento desta alteração estética para melhores níveis de resultado. Objetivo: conduzir uma investigação sobre os resultados atuais de pesquisas que envolvam o microagulhamento associado ao uso de Minoxidil, plasma rico em plaquetas e/ou mesoterapia. Metodologia: foram feitas pesquisas no banco de dados da PubMed e Scielo em abril de 2021 buscando-se os termos “minoxidil AND microneedling”. Resultados e Discussões: os resultados obtidos têm convergido para a proposta de que a associação do método de rolagem (microagulhamento) com a aplicação tópica do vasodilatador (minoxidil) apresenta um padrão de crescimento capilar nunca alcançado pela terapia convencional disponível, e que, se acrescentar plasma rico em plaquetas e/ou soluções através da mesoterapia, os resultados podem ser ainda mais vantajosos. Conclusão: novos estudos são necessários para abranger as vertentes ainda não elucidadas para o tratamento da alopecia, contudo, os resultados até aqui obtidos são promissores para o sucesso da reposição capilar.Palavras chave: Microagulhamento, Minoxidil, Alopecia AbstractIntroduction: alopecia linked to androgenic hormonal factors is something that has long been the subject of studies and knowledge applications worldwide. This pattern of hairloss, mainly related to males, has therapies that are currently limited to interruption of hair loss with slight growth progression in some cases. In this regard, a new microneedlingtechnique, with or without adjuvant therapies, associated with well-established methods such as minoxidil has led the treatment of this esthetic alteration to better levels of results. Objective: to conduct an investigation into the current results of research involving microneedling associated with the use of Minoxidil, platelet-rich plasma and/or mesotherapy. Methodology: searches were conducted in the PubMed and Scielo database in April 2021, searching for the terms “minoxidil AND microneedling”. Results and Discussions: the results obtained have converged to the proposal that the association of the rolling method(microneedling) with the topical application of a vasodilator (minoxidil) presents a pattern of hair growth never achieved by the available conventional therapy, and that, if addedplatelet-rich plasma and/or solutions through mesotherapy, the results can be even more advantageous. Conclusion: further studies are needed to cover aspects that have notyet been elucidated for the treatment of alopecia, however, the results obtained so far are promising for the success of hair replacement.Keywords: Microneedling, Minoxidil, Alopecia

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“…New technologies such as fractional lasers and MN devices may be used to bypass this complicated step in drug delivery to the deeper skin layers and the cutaneous vasculature. 10 Microchannels are created within the epidermis using fractioned resurfacing. This is referred to in the literature as TED.…”

Section: Discussionmentioning

confidence: 99%

“…This presents a barrier to topical drug absorption. New technologies such as fractional lasers and MN devices may be used to bypass this complicated step in drug delivery to the deeper skin layers and the cutaneous vasculature 10 …”

Section: Discussionmentioning

confidence: 99%

Comparative study between topical application of triamcinolone acetonide after fractional carbon dioxide laser versus microneedling in the treatment of resistant alopecia areata

Omar¹,

Obaid

Sayedahmed

2022

Dermatologic Therapy

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Alopecia areata (AA) is a disease that affects the psychological well‐being of the affected individuals. Laser‐assisted drug delivery and microneedling (MN) are promising methods for the treatment of different dermatological diseases. The aim of the study was to compare the efficacy of topical application of triamcinolone acetonide after fractional carbon dioxide laser versus MN in the treatment of resistant AA from a clinical and dermoscopic perspective. Thirty patients were randomly divided into two groups of 15 patients each: the Laser group received fractional CO2 laser treatment followed by topical application of triamcinolone acetonide, and the MN group received dermapen treatment followed by topical application of triamcinolone acetonide. In our study, we found no statistically significant difference between the studied groups before and after treatment, except for black dot, which is higher in the MN group than in the laser group (46.7% vs. 13.3%). There is a statistically significant difference between the studied groups in terms of treatment response at the first follow‐up, with 13.3% of the laser group seeing terminal hair regrowth compared to 0 in the MN group after 12 weeks. Regarding the degree of improvement, there was no statistically significant difference between the laser group and the MN group. The use of fractional CO2 laser and MN for transepidermal drug delivery (TED) allowed for more uniform drug distribution. There was no significant difference between the two treatment methods in terms of their high effectiveness in the treatment of resistant AA.

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The rise of transcutaneous drug delivery for the management of alopecia: a review of existing literature and an eye towards the future

Cited by 12 publications

References 43 publications

Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth

Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth

Comparative study between topical application of triamcinolone acetonide after fractional carbon dioxide laser versus microneedling in the treatment of resistant alopecia areata

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