The Rising Incidence of Major Salivary Gland Cancer in the United States

Signore, Anthony G. Del; Megwalu, Uchechukwu C.

doi:10.1177/014556131709600319

Cited by 74 publications

(56 citation statements)

References 14 publications

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“…Furthermore, our results of the increased annual incidence of major SGC were supported the results by Boukheris et al and Signore et al who studied the SEER database during 1992‐2006 and during 1973‐2009, respectively. These results also revealed an increased incidence trend unlike other countries like Spain .…”

Section: Discussionsupporting

confidence: 92%

“…These results also revealed an increased incidence trend unlike other countries like Spain . This observation corresponds to the results reported in several other studies, including studies that reported a significant increase from 1975 to 1988 and 2005 to 2014, and other SEER‐based studies that reported an increase in incidence from 1973 to 2009 . Notwithstanding, we have found an improvement in the incidence trend of major SGC.…”

Section: Discussionsupporting

confidence: 92%

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Examined and positive lymph nodes counts and lymph nodes ratio are associated with survival in major salivary gland cancer

et al. 2019

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Background We aimed to investigate the prognostic role of examined (dissected) lymph nodes (ELNs), negative LNs (NLNs), and positive (metastatic) LNs (PLNs) counts and LN ratio (LNR = PLNs/ELNs×100) in patients with major salivary gland cancer (SGC). Methods Data were retrieved for major SGC patients diagnosed between 1988 and 2011 from Surveillance, Epidemiology, and End Results program. Results We have included 5446 patients with major SGC. Most patients had parotid gland cancer (84.61%). Patients having >18 ELNs, >4 PLNs, and >33.33% LNR were associated with a worse survival. Moreover, older age, male patients, grade IV, distant stage, unmarried patients, submandibular gland cancer, and received chemotherapy but not received surgery were significantly associated with a worse survival. Conclusions We demonstrated that patients with >18 ELNs and >4 PLNs counts, and >33.33% LNR were high‐risk group patients. We strongly suggest adding the ELNs and PLNs counts and/or LNR into the current staging system.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Examined and positive lymph nodes counts and lymph nodes ratio are associated with survival in major salivary gland cancer

et al. 2019

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“…They account for approximately 6% of all head and neck tumors and 0.3% of all malignancies in the United States . The incidence of malignancy, however, has increased from 10.4 per 1,000,000 in 1973 to 16 per 1,000,000 in 2009 . The tumors are commonly located in parotid glands followed by the submandibular glands, the minor salivary glands, and the sublingual glands.…”

Section: Introductionmentioning

confidence: 99%

Risk of malignancy associated with cytomorphology subtypes in the salivary gland neoplasm of uncertain malignant potential (SUMP) category in the Milan System: A bi‐institutional study

Chowsilpa

Lose

et al. 2019

Cancer Cytopathology

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BACKGROUND: Salivary gland neoplasm of uncertain malignant potential (SUMP) is a diagnostic category in the Milan System for Reporting Salivary Gland Cytopathology. The objective of this study was to assess the risk of neoplasm (RON) and the risk of malignancy (ROM) in SUMP cases by evaluating them based on their prominent cytomorphology. METHODS:The pathology databases were searched for cases of fine-needle aspiration-diagnosed SUMP at The Johns Hopkins Hospital and Northwestern University from 2013 to 2018. Only cytopathology cases diagnosed as SUMP that had available surgical follow-up were included. RESULTS: Sixty-five patients with SUMP were identified, including 31 men and 34 women who ranged in age from 15 to 87 years (mean age, 55.2 years). Sixty-five cases had histologic follow-up, including 13 (20%) with basaloid features, 13 (20%) with oncocytic features, and 39 (60%) with unspecified features. No cases with clear cell features were found. Overall, the RON in the SUMP category was 95.4% (62 of 65 cases), and the ROM was 33.8% (22 of 65 cases). The RON in SUMPs with basaloid, oncocytic, and unspecified subtypes was 92.3%, 100%, and 94.9%, respectively, whereas the ROM was 38.5%, 7.7%, and 41%, respectively. The most common benign neoplasm was pleomorphic adenoma (23.1%), whereas mucoepidermoid carcinoma (9.2%) was the most common malignant neoplasm. CONCLUSIONS: This study shows that the ROM differs significantly based on cytomorphology subtypes, whereas the overall ROM is approximately the same as the target rate in the Milan System for Reporting Salivary Gland Cytopathology. Moreover, the RON remains high in the SUMP category among different cytomorphology subtypes.Adequate sampling, immunohistochemical staining, and familiarity with metaplastic and reactive changes may improve the diagnosis.

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“…According to a recent SEER (Surveillance, Epidemiology, and End Results Program) database study, the incidence of major salivary gland carcinoma is increasing, particularly among small cancers. This study also demonstrated an increase in N+ and M1 cases, an increase in mucoepidermoid, acinic cell, and squamous cell carcinomas (SCCAs), and a decrease in adenoid cystic carcinomas (ACCs) and carcinoma ex‐pleomorphic adenomas over the past 36 years …”

Section: Introductionmentioning

confidence: 99%

“…This study also demonstrated an increase in N+ and M1 cases, an increase in mucoepidermoid, acinic cell, and squamous cell carcinomas (SCCAs), and a decrease in adenoid cystic carcinomas (ACCs) and carcinoma ex-pleomorphic adenomas over the past 36 years. 2 Among SGNs, parotid tumors are far more common than neoplasms in the other sites. Although parotid tumors are usually benign, the frequency of tumors overall makes the parotid gland the most common site of cancer.…”

Section: Introductionmentioning

confidence: 99%

AHNS series: Do you know your guidelines? Diagnosis and management of salivary gland tumors

2018

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The Rising Incidence of Major Salivary Gland Cancer in the United States

Cited by 74 publications

References 14 publications

Examined and positive lymph nodes counts and lymph nodes ratio are associated with survival in major salivary gland cancer

Examined and positive lymph nodes counts and lymph nodes ratio are associated with survival in major salivary gland cancer

Risk of malignancy associated with cytomorphology subtypes in the salivary gland neoplasm of uncertain malignant potential (SUMP) category in the Milan System: A bi‐institutional study

AHNS series: Do you know your guidelines? Diagnosis and management of salivary gland tumors

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