The rising prevalence and changing age distribution of multiple sclerosis in Manitoba

Marrie, Ruth Ann; Yu, Nancy; Blanchard, James; Leung, Stella; Elliott, Lawrence

doi:10.1212/wnl.0b013e3181cf6ec0

Cited by 270 publications

(309 citation statements)

References 27 publications

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“…The effects of this assumption are likely to be small, given that most MS cases are diagnosed at age 20 years and older. The model shows peak incidence occurring at a later age than other Canadian studies undertaken in Nova Scotia 21 and Manitoba; 22 however, the overall incidence rates produced by the model were similar to these earlier studies.…”

Section: Strengths and Limitationssupporting

confidence: 71%

“…22 We generated prevalent MS actors in two steps. First, we applied empirical estimates of sex-and age-specific MS incidence rates to the model's synthetic Canadian population for each year, both historical and projected.…”

Section: Ms Status: Incidencementioning

confidence: 99%

“…Incidence and prevalence rates estimated from the British Columbia (BC) population were of comparable magnitude to those of the published studies from Canadian settings and provincial/territorial pilots. [22][23][24][25] Using these age-and sex-specific incidence rates, actors were classified as being diagnosed with MS, based on each actor's risk of developing MS at the beginning of each new calendar year. Incident MS cases accumulated over time to generate prevalent cases of MS.…”

Section: Ms Status: Incidencementioning

confidence: 99%

See 2 more Smart Citations

Multiple sclerosis in Canada 2011 to 2031: results of a microsimulation modelling study of epidemiological and economic impacts

Amankwah

Marrie

Bancej

et al. 2017

Health Promot Chronic Dis Prev Can

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Section: Strengths and Limitationssupporting

confidence: 71%

Section: Ms Status: Incidencementioning

confidence: 99%

Section: Ms Status: Incidencementioning

confidence: 99%

See 1 more Smart Citation

Multiple sclerosis in Canada 2011 to 2031: results of a microsimulation modelling study of epidemiological and economic impacts

Amankwah

Marrie

Bancej

et al. 2017

Health Promot Chronic Dis Prev Can

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“…7 One study examining hospital stays in newborns of mothers with MS 11 reported longer stays (relative risk 5 1.5; 95% CI: 0.99-2.3) compared with newborns of mothers without MS 11 ; however, the authors speculated this was attributable to the common practice of discharging mother and newborn home together, as no other adverse birth outcomes were observed. Our study differed from previous studies 4,11 examining birth hospitalizations in a number of ways: first, our study included a cohort of women with clinically definite MS confirmed by an MS specialist neurologist, rather than relying on a single ICD code (a valid algorithm for MS requires multiple ICD billing codes recorded over a period of time) 23 to identify MS. Second, we found that the length of birth hospitalization in patients with MS was not associated with disease duration or level of disability, which was not previously examined. These findings should be considered exploratory in nature and require confirmation.…”

mentioning

confidence: 99%

Birth hospitalization in mothers with multiple sclerosis and their newborns

Zhao

Zhu

et al. 2013

Neurology

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Objective: To compare the duration of birth hospitalization in mothers with multiple sclerosis (MS) and their newborns relative to the general population and to investigate the impact of MS-related clinical factors on the length of birth hospitalization stays.Methods: Data from the British Columbia Perinatal Database Registry and the British Columbia MS database were linked in this retrospective cohort study. The duration of birth hospitalization in mothers with MS and their newborns (n 5 432) were compared with a frequency-matched sample of the general population (n 5 2,975) from 1998 to 2009. Clinical factors investigated included disease duration and disability, as measured by the Expanded Disability Status Scale. A multivariable model (generalized estimating equations) was used to analyze the association between MS and duration of birth hospitalization, adjusting for factors such as maternal age, diabetes, hypertension, and consecutive births to the same mother. Additional analyses included propensity score matching to further balance cohort characteristics.Results: Compared with the general population, the duration of birth hospitalization was not statistically or clinically different for mothers with MS or their newborns (median differences 5 11.5 and 12.1 hours, respectively; adjusted p . 0.4). Lengths of birth hospitalization were not significantly associated with disease duration (adjusted p . 0.7) or level of disability (adjusted p . 0.5). Findings remained virtually unchanged after propensity score matching.Conclusions: Birth hospitalization has been understudied in women with MS. Contrary to existing studies, we found that MS was not associated with a longer birth hospitalization. This study provides assurance to expectant mothers with MS, their families, and health care providers. Multiple sclerosis (MS) is a chronic degenerative disease of the CNS, often manifesting in women of childbearing age. 1 Fatigue and pelvic organ dysfunction are common, 2 which may cause difficult labor and prolonged birth hospitalization. MS has been associated with a greater risk of difficult labor, 3 assisted vaginal delivery, 3 cesarean delivery, 4 as well as impaired fetal growth and prematurity. [3][4][5][6] Although not all agree, more recent studies found no link between MS and adverse perinatal outcomes. 7-10 However, the durations of birth hospitalization were not examined in these studies. To our knowledge, only 2 studies have examined birth hospitalization in MS 4,11 ; both were from the United States and reported longer hospital stays for mothers with MS 4,11 and their newborns 11 compared with the general population. Prolonged stays can have negative consequences, including an increased risk of hospital-acquired infection as well as creating a strain on scarce health care resources. 12 By linking 2 comprehensive population databases, the British Columbia Multiple Sclerosis (BCMS) database and the British Columbia Perinatal Database Registry (BCPDR), we

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“…Older people with MS constitute a growing proportion of the MS population 53 ; however, little is known about aging with MS or factors that affect successful aging with MS. In order to describe healthy aging from the perspective of the older person with MS, researchers interviewed 18 people who were 55 years of age and older with symptoms for 20 or more years.…”

Section: Research On Aging and Older Adults With Multiple Sclerosismentioning

confidence: 99%

Drawing on Related Knowledge to Advance Multiple Sclerosis Falls-Prevention Research

Ploughman¹,

Deshpande²,

Latimer-Cheung³

et al. 2014

International Journal of MS Care

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There is much to be learned from falls-related research outside the field of multiple sclerosis (MS), as well as from work within the MS field but not specific to falls or falls prevention. This article describes three examples of such bodies of work that have potential to broaden approaches to falls-prevention research: 1) sensory components of postural control among older adults, 2) lessons learned from physical activity promotion among people with spinal cord injury (SCI), and 3) aging among people with MS. Age-related deterioration in visual, vestibular, and somatosensory systems or in sensory integration can adversely affect postural control and can contribute to falls in older people. Sensory-specific interventions designed for improving balance in older people could be adapted for preventing falls in individuals with MS. Spinal Cord Injury (SCI) Action Canada's strategy for disseminating physical activity promotion interventions for adults with SCI has been successful and widely accepted by community partners. Many of the peer-based interventions developed by SCI Action Canada are potentially relevant and could be adapted to the MS population for both physical activity promotion and falls prevention. Considering that older people with MS constitute a growing proportion of the MS population and over 70% of older people with MS report moderate to extreme balance problems, falls prevention should be one of the key components, particularly for MS management in older or more disabled groups. Overall, given people's different ages, symptoms, strengths, and barriers, a tailored MS falls-prevention intervention that includes peer/caregiver support is critical. Int J MS Care. 2014;16:163-170.

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The rising prevalence and changing age distribution of multiple sclerosis in Manitoba

Cited by 270 publications

References 27 publications

Multiple sclerosis in Canada 2011 to 2031: results of a microsimulation modelling study of epidemiological and economic impacts

Multiple sclerosis in Canada 2011 to 2031: results of a microsimulation modelling study of epidemiological and economic impacts

Birth hospitalization in mothers with multiple sclerosis and their newborns

Drawing on Related Knowledge to Advance Multiple Sclerosis Falls-Prevention Research

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