The rising tide of early-onset colorectal cancer: a comprehensive review of epidemiology, clinical features, biology, risk factors, prevention, and early detection

Patel, Swati; Karlitz, Jordan J.; Yen, Timothy; Lieu, Christopher H.; Boland, C. Richard

doi:10.1016/s2468-1253(21)00426-x

Cited by 351 publications

(207 citation statements)

References 128 publications

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“… 33 , 34 In addition, a higher proportion of CRC in young patients occur in the distal colon or rectum compared to older patients. 3 , 4 , 5 Risk factors more strongly associated with distal colon or rectum cancer and increasing in prevalence are likely to contribute to the development of EOCRC. We found a stronger association between heavy drinking with distal CRC than proximal CRC, consistent with a recent meta-analysis study (4276 CRC cases, 15,802 controls) in which heavy alcohol consumption was associated with increased risk of distal colon and rectal cancer but not proximal colon cancer.…”

Section: Discussionmentioning

confidence: 99%

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Alcohol consumption, polygenic risk score, and early- and late-onset colorectal cancer risk

Chen

Guo

et al. 2022

eClinicalMedicine

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Section: Discussionmentioning

confidence: 99%

“… 1 , 2 Evidence has suggested distinct environmental and genetic risk factors and clinicopathological features of EOCRC and late-onset CRC (LOCRC). 3 , 4 , 5 …”

Section: Introductionmentioning

confidence: 99%

Alcohol consumption, polygenic risk score, and early- and late-onset colorectal cancer risk

Chen

Guo

et al. 2022

eClinicalMedicine

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“…Early diagnosis is very important for treatment and survival in colorectal cancer, as in other types of cancer. In their study, Patel et al [31] indicated that early diagnosis was very important in the prognosis of colorectal cancer. González et al [32] reported that colorectal cancer cases were increasing rapidly and that early diagnosis was very important to prevent the rapid increase in cancer cases and mortality rates.…”

Section: Discussionmentioning

confidence: 99%

Determination of Risk Awareness and Knowledge Levels of First Degree Relatives of Colorectal Cancer Patients; The Case of Turkey

Temiz¹,

DOGER²,

Akın³

et al. 2022

Preprint

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Background Since genetic factor is an important factor in the occurrence of cancer in colorectal cancer, risk awareness and knowledge level of first-degree relatives of patients with colorectal cancer is very important in cancer prevention. Aim This study was conducted to determine the knowledge level of first-degree relatives of colorectal cancer patients about colorectal cancer and their awareness of colorectal cancer risk factors. Method This is a descriptive study. 251 patients undergoing chemotherapy with a diagnosis of colorectal cancer in a university hospital constituted the sample of the study. The data were obtained by face-to-face interview method using the Information Form and the Questionnaire for the Evaluation of Knowledge and Awareness Levels of Colorectal Cancers. Results The mean score of the Questionnaire for the Evaluation of Knowledge and Awareness Levels of Colorectal Cancers was found to be 10.61 ± 5.65. This score indicated that individuals undergoing chemotherapy with a family history of colorectal cancer had a moderate level of knowledge and awareness about colorectal cancer. Two-thirds of the participants reported that they had knowledge that diabetes, obesity, lifestyle, smoking and alcohol use increased the risk of colorectal cancer. Conclusion The results revealed that It was observed that elderly, low educated, male and rural-dwelling participants needed more education on improving the level of knowledge and awareness about colorectal cancers. Implications for Practice: In order to prevent colorectal cancer and reduce the burden of disease, it is seen that first-degree patient relatives need to be more conscious and educated.

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“…Dank der Vorsorgekoloskopie haben in Deutschland in den letzten 20 Jahren die altersstandisierten Neuerkrankungen um mehr als 20 % und die Darmkrebstodesfälle bei den über 55-Jährigen um mehr als 35 % abgenommen [42]. Es erkranken nun aber immer mehr junge (< 50 Jahre) Erwachsene [17,32,43 Datenquelle: [33].…”

Section: Darmkrebsunclassified

Krebsrisiko bei Prädiabetes und Typ-2-Diabetes mellitus

Scherübl

2022

Diabetologie und Stoffwechsel

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ZusammenfassungKrebs ist nun die führende Todesursache bei Typ-2-Diabetes mellitus (T2D). Prädiabetes und T2D erhöhen das Risiko für bestimmte Tumoren. Zu den Prädiabetes- bzw. T2D-assoziierten Malignomen zählen gastrointestinale, gynäkologische, urologische und endokrine Karzinome aber auch Leukämien. Prädiabetes und T2D bedingen eine 1,2- bis 2,7-fach erhöhte Krebssterblichkeit. Zugrundeliegende Mechanismen der Assoziation zwischen T2D und Krebs beinhalten die chronische Hyperglykämie, einen chronischen systemischen Entzündungszustand, oxidativen Stress, Dyslipidämie, die Insulinresistenz sowie chronisch erhöhte Spiegel von insulin-like growth factor 1 (IGF-1) und von Insulin. Eine dauerhafte Gewichtsreduktion kann das Krebsrisiko adipöser T2D-Patienten signifikant senken. Ein gesunder Lebensstil und die regelmäßige Teilnahme an Vorsorgeuntersuchungen sind wichtig und können die Krebsmortalität von Diabetespatienten erheblich verringern.

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The rising tide of early-onset colorectal cancer: a comprehensive review of epidemiology, clinical features, biology, risk factors, prevention, and early detection

Cited by 351 publications

References 128 publications

Alcohol consumption, polygenic risk score, and early- and late-onset colorectal cancer risk

Alcohol consumption, polygenic risk score, and early- and late-onset colorectal cancer risk

Determination of Risk Awareness and Knowledge Levels of First Degree Relatives of Colorectal Cancer Patients; The Case of Turkey

Krebsrisiko bei Prädiabetes und Typ-2-Diabetes mellitus

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