The Risk Associated With Iron Deficiency Anemia for Simple Febrile Seizures in Children: A Case–control Study

Tripathy, Debajyoti; Tomar, Rampal Singh; Gupta, Ashish Kumar; Ghuliani, Ranjit

doi:10.32677/ijch.2020.v07.i01.007

Cited by 3 publications

(11 citation statements)

References 9 publications

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“…In our study among case group with febrile seizures, 38 (69%) were males and 17 (31%) were females in case group versus 32 (59%) males, 23 (41%) females in control group. There was a male predominance in both case and control group and that came in agreement with the studies of Khanna et al (12) and Tripathy et al (15) . But in Surani et al (14) the reverse was observed as males were 33.3% only versus 66.7% females with female predominance in percentage.…”

Section: Discussionsupporting

confidence: 91%

“…Average mean of MCH in case group was statistically significantly lower than normal (30.96±3.58 gms), while in control group it was within normal (32.68±2.32 gms). It came in agreement with Khanna et al (12) , Jang et al (13) , Tripathy et al (15) , and Majumdhar et al (19) .…”

Section: Discussionsupporting

confidence: 91%

“…Average mean Hb level in our studied case group was statistically significant lower than normal (10.73±1.44 g/dl) however average mean Hb level in controls was within normal (11.77±1.24 g/dl). This came in consistence with Tripathy et al (15) and Vikash et al (18) . While in Surani et al (14) Hb level was (8.87 g/dl) and in Majumdhar et al (19) mean it was (8.92 g/dl).…”

Section: Discussionsupporting

confidence: 86%

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Iron Deficiency Anemia in Children with Febrile Convulsions: A Case–control Study at Sohag University Hospital

Gaballah¹,

Abosdera²,

Abou-Taleb³

2022

The Egyptian Journal of Hospital Medicine

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Background: Iron is necessary for healthy growth and development, and iron deficiency has been linked to behavioural problems, mental impairment, and reduced immunological function in children. Iron deficiency anemia (IDA) affects 48.5 percent of Egyptian preschoolers (aged 6 to 59 months). Objective: The aim of this study was to evaluate the iron status in children with first febrile seizure (FFS). Patients and Methods: This was a case-control hospital-based study that included children with febrile convulsion as case group and children with febrile illness without convulsion as controls, aged from 6 months to 6 years at Sohag University Hospital. Our study included 110 children, 55 as case group and 55 as controls from June 2019 to December 2020. Results: Pallor observed in 28% only of case group against only 17% of control group. The mean temperature at which children start to convulse was 39.36±51. The mean Hb level of case group was statistically significantly lower than normal and was 10.73±1.44 versus 11.77±1.24 for control group. The mean of serum ferritin was statistically significantly lower than normal and was 13.41±11.71 versus 30.18±8.9 for control group. The mean of total iron binding capacity (TIBC) was statistically significantly higher than normal and was 430.91±87.8 versus 362.73±63.81 for control group. Conclusion:The result suggests that iron deficiency anemia may be a risk factor for febrile seizures. Thus screening for IDA should be considered in children with febrile seizures. Fever can worsen the negative effect of anemia or iron deficiency on the brain and a seizure can occur as a consequence. This suggests that iron deficient children are more prone to febrile seizures.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 86%

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Iron Deficiency Anemia in Children with Febrile Convulsions: A Case–control Study at Sohag University Hospital

Gaballah¹,

Abosdera²,

Abou-Taleb³

2022

The Egyptian Journal of Hospital Medicine

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“…Pisacane et al reported a significantly higher rate of iron deficiency anemia in children with FFS compared to the control group in a case-control study of 146 cases over a period of 6-24 months and 293 in the control group; Naveed-ur-Rehman and Billo proposed the same result in a case-control study of 30 cases and 30 controls [11][12] . Daoud et al In a case-control study of 75 cases and 75 controls, with no significant difference in HB, MCV, and MCH, only low PF levels were associated with FFS and could play a role; In contrast, Kobrinsky et al showed in a case-control study of 25 cases and 26 controls that anemia raises the FFS threshold, and iron deficiency may protect against the development of febrile seizures [13][14] . FFS was more common in the 6-12-month age group than in the 12-24month age group.…”

Section: Discussionmentioning

confidence: 99%

Iron Deficiency Association as A Possible Cause of First Febrile Seizure

Khan¹,

Naibzai²,

Sethi³

et al. 2021

PJMHS

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Aim: A controlled clinical study was conducted to investigate the relationship between iron deficiency and first episode of febrile seizure in children 6-60 months of age. Place and Duration:In the Pediatric Medicine department of ShifaInternationalHospital Islamabadforsix months duration from 15thMay 2020 to 30thNovember 2020. Methods:Hematological parameters for iron levels, including HB, MCV, MCHC and plasma ferritin, were determined in 75 patients who experienced a first febrile episode. 75 children without febrile seizures were taken as controls and the same markers were compared in both groups. Results: The most important factors influencing the first attack of febrile seizure were HB, MCV, and serum ferritin levels. Conclusion: Iron deficiency is significantly associated with the occurrence of the first febrile episode in children. Key words:Iron deficiency anemia, Iron deficiency, Febrile convulsions, Febrile attacks.

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“…A high RDW means they differ in size more significantly, a characteristic of IDA [ 29 ]. Among the 23 studies analyzed, five of which were conducted by Sharif et al, Yarigarravesh et al, Shaikh et al, Jang et al, and Tripathy et al reported that Hb exhibited no statistically significant association, with corresponding p-values of 0.06, 0.37, 0.44, 0.77, and 0.35, respectively [ 10 , 17 , 19 , 20 , 22 ]. The statistical significance of mean Hb levels was observed in all the studies except the one mentioned earlier [ 5 - 9 , 11 - 16 , 21 , 23 - 27 ].…”

Section: Reviewmentioning

confidence: 99%

Associative Patterns Between Iron Deficiency Anemia and Febrile Seizures in the Five to 60 Months Age Group: A Comprehensive Systematic Review

Bakkannavar,

Faheem,

Jaiswal

et al. 2024

Cureus

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Febrile seizures (FS) are commonly seen in younger age groups. The cause of seizures is multifactorial, including viral illnesses, certain vaccines such as MMR (measles, mumps, rubella), family history of FS, and certain mineral deficiencies like zinc. Iron deficiency anemia (IDA) is the most common cause of anemia in children of the same age group. The systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. This review aimed to investigate the correlation between IDA and fever convulsions. A systematic literature search was conducted using PubMed and Google Scholar databases for studies published between January 2013 and September 2023. The following keywords were used to search the articles: “children”, “febrile seizures”, and “iron deficiency anemia”, using all possible combinations and using the word “and” between them. Following the inclusion and exclusion criteria application, we included 23 case-control studies written in the English language in this study. Quality assessment of studies was done using the Newcastle Ottawa Scale.

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The Risk Associated With Iron Deficiency Anemia for Simple Febrile Seizures in Children: A Case–control Study

Cited by 3 publications

References 9 publications

Iron Deficiency Anemia in Children with Febrile Convulsions: A Case–control Study at Sohag University Hospital

Iron Deficiency Anemia in Children with Febrile Convulsions: A Case–control Study at Sohag University Hospital

Iron Deficiency Association as A Possible Cause of First Febrile Seizure

Associative Patterns Between Iron Deficiency Anemia and Febrile Seizures in the Five to 60 Months Age Group: A Comprehensive Systematic Review

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