Dental implants provide reliable and predictable solutions to replacing missing teeth in partially or fully edentulous patients. 1 Preserving the healthy condition of tissues surrounding the dental implant is one of the main strategies for long-term maintenance. 2 However, this goal is not easily achievable, as infectious diseases in the periodontal tissues may disturb the function of osseointegrated implants. 3 Inflammation of the peri-implant soft tissue creates a reversible condition called peri-implant mucositis, characterized by bleeding on gentle probing, though without loss of supporting bone. 4 According to the International Workshop for the Classification of Periodontal and Peri-Implant Diseases (2017), periimplantitis is the progression of mucositis, characterized by nonreversible and progressive loss of supporting bone and associated with bleeding and/or suppuration on probing; bone loss may be observed radiographically. 4,5 Consensus exists that peri-implant mucositis and peri-implantitis are caused by an inflammatory response to biofilm accumulation, 6 similar to gingivitis and periodontitis. 7 However, a variety of patient-, prosthetic-, and implant-related factors may influence their occurrence. Patient-related indicators include smoking, poor oral hygiene, and systemic diseases, such as diabetes mellitus and periodontal disease. 2,8-10 The literature has examined prothesis-related factors that increase a patient's risk of developing peri-implant bone loss. For instance, several studies 2,11 have reported a relationship between cemented restorations and peri-implantitis, which is likely due to the presence of residual cement in the sulcus. Finally, implant-related factors, such as anatomic localization (anterior/posterior, maxilla, or mandible), are suggested as potential indicators for the development of peri-implant bone loss. Although the literature shows a tendency toward a higher prevalence of peri-implantitis in patients with mandibular implants, [12][13][14][15] consensus on this association does not exist. 2,16,17 The prevalence of peri-implantitis has been evaluated by several clinical studies with different follow-ups. [18][19][20] A previous systematic review 21 assessed the prevalence, extent, and severity of peri-implant diseases in 11 studies. The prevalence of peri-implant mucositis and peri-implantitis was 43% (ranging from 19% to 65%) and 22% (ranging from 1% to 47%), respectively. Nevertheless, these results should be interpreted with caution owing to differences in case definitions, follow-up times, and patient selection in the assessed studies. Additionally, relevant anatomic localization conditions related to prostheses and implants were not included in the analysis.Few previous studies have specifically investigated the relationship between implant location and peri-implantitis prevalence. Most of these studies found a greater occurrence of peri-implantitis in the posterior location of the mandible. 11,12 Anatomic localization factors, such as bone characteristics, narrow band...