The Risk of Acute Myocardial Infarction and Arterial Hypertension in a Cohort of Male Employees of a Siberian Group of Chemical Enterprises Exposed to Long-Term Irradiation

Karpov, A.B.; Semenova, Yulia V.; Takhauov, R. M.; Litvinenko, T. M.; Kalinkin, D.

doi:10.1097/hp.0b013e318249fa59

Cited by 7 publications

(6 citation statements)

References 17 publications

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“…Механизмы атерогенеза и АГ, обусловленные техногенным облучением, особенно при «малых» дозах и низкой мощности дозы ИИ, до сих пор остаются спорными; ССЗ оцениваются сегодня как наиболее вероятный стохастический эффект радиационного воздействия [1][2][3][4][5][6][7]. В последние годы для малообновляющихся тканей (эндотелия и миоцитов сосудистой стенки) активно обсуждается наличие особых клеточных эпигенетических эффектов действия ИИ [13].…”

Section: Discussionunclassified

“…Персонал предприятий атомной отрасли характеризуется особенностями производственной деятельности, десинхронией биологических ритмов, психоэмоциональным напряжением и другими характеристиками, которые вызывают раннее формирование ССЗ [1,2].…”

Section: Introductionunclassified

“…В последние годы большое внимание уделяется антропогенным и техногенным факторам развития ССЗ. Активно обсуждается вопрос о влиянии техногенного облучения на риск заболеваемости и смертности вследствие ССЗ с учетом расширения использования источников ионизирующего излучения (ИИ) в промышленных и медицинских целях [1][2][3][4][5][6][7]. При этом эндотелиальная дисфункция (ЭД) определяет патогенез ССЗ, на начальном этапе которого обнаруженные сосудистые нарушения могут быть обратимы [8,9].…”

Section: Introductionunclassified

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Markers of endothelial dysfunction in patients with arterial hypertension exposed to occupational irradiation of low intensity

et al. 2020

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Aim To study the association between concentrations of endothelial dysfunction (ED) markers and arterial hypertension (AH) in people who were exposed to long-term action of “low-dose” ionizing radiation.Material and methods The study subjects were men of middle age (45–55 years) who were workers of the Siberian Integrated Chemical Plant with the length of service on the shop floor of at least 5 years. The subjects were divided into the main group (n=96) consisting of workers with grade 1-2 AH and the control group (n=48) consisting of arbitrarily healthy workers. Both groups contained workers who had been exposed to long-term occupational low-intensity irradiation (γ-radiation) and those not exposed to this irradiation. The study evaluated risk factors for cardiovascular diseases, presence of concomitant diseases, blood biochemistry (concentrations of glucose, high-sensitivity C-reactive protein (hsCRP), total cholesterol, low-density lipoproteins, high-density lipoproteins, triglycerides, creatinine, and ED markers, including endothelin, angiotensin II, von Willebrand factor, C-type natriuretic peptide, tissue plasminogen activator, tumor necrosis factor α (TNF-α), and homocysteine, major clinical data, total dose of external irradiation, and the content of 239Pu in the body.Results AH was associated primarily with excessive body weight and severity of atherogenic dyslipidemia and homocysteinemia. Higher plasma concentrations of TNF-α and a tendency to increasing hsCRP in the AH group, as distinct from the control group of arbitrarily healthy men, indicated a proinflammatory shift. The ED markers were related with clinical data of AH patients and associated with the lipid profile and increased blood concentrations of inflammatory mediators. The radiation exposure did not change the ED marker array in AH patients, which did not allow recommendation of the studied plasma indexes for detection of vascular endothelial injury in workers with AH of the Siberian Integrated Chemical Plant.Conclusion The study results evidenced the absence of adverse effects of long-term occupational exposure to low-intensity radiation on the vascular endothelium as evaluated by ED markers. In men aged 45–55 years, AH was associated primarily with excessive body weight, homocysteinemia, and atherogenic dyslipidemia.

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Section: Discussionunclassified

Section: Introductionunclassified

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Markers of endothelial dysfunction in patients with arterial hypertension exposed to occupational irradiation of low intensity

et al. 2020

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“…GR over-expression has an aggravation effect during rats' myocardial infarction (Mihailidou et al, 2009). The disease risk greatly increases while exposed with irradiation, the hazard of which is believed to potentiate the negative effects on pathogenesis of AMI (Karpov et al, 2012). Because genes in this pathway react to both radiation exposure and GR-ablation, we hypothesize that the increased risk of AMI post radiation exposure could be related to GR activation.…”

Section: Identification Of Radiation-induced Pathways Related To Glucmentioning

confidence: 98%

Biological pathway selection through Bayesian integrative modeling

Zheng

Yan

Suchindran

et al. 2014

Statistical Applications in Genetics and Molecular Biology

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Pathway analysis has become a central approach to understanding the underlying biology of differentially expressed genes. As large amounts of microarray data have been accumulated in public repositories, flexible methodologies are needed to extend the analysis of simple case-control studies in order to place them in context with the vast quantities of available and highly heterogeneous data sets. To address this challenge, we have developed a two-level model, consisting of 1) a joint Bayesian factor model that integrates multiple microarray experiments and ties each factor to a predefined pathway and 2) a point mass mixture distribution that infers which factors are relevant/irrelevant to each dataset. Our method can identify pathways specific to a particular experimental trait which are concurrently induced/repressed under a variety of interventions. In this paper, we describe the model in depth and provide examples of its utility in simulations as well as real data from a study of radiation exposure. Our analysis of the radiation study leads to novel insights into the molecular basis of time- and dose- dependent response to ionizing radiation in mice peripheral blood. This broadly applicable model provides a starting point for generating specific and testable hypotheses in a pathway-centric manner.

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“…l Estimate derived by fitting a linear model by (inverse-variance) weighted least squares, applied to the adjusted standardized relative risk provided in Table 2 of Karpov et al (2012), and using the delta method to derive the variance of the ERR: see Appendix A. Average cardiac doses of 0.01, 0.04, 0.1225, and 0.25 Sv were assumed for the respective groups with the following specified ranges of effective doses: 2 of Markabayeva et al (2018).…”

Section: Atomic Bomb Survivorsmentioning

confidence: 99%

Low- and moderate-dose non-cancer effects of ionizing radiation in directly exposed individuals, especially circulatory and ocular diseases: a review of the epidemiology

Little

Azizova

Hamada

2021

International Journal of Radiation Biology

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Purpose: There are well-known correlations between high and moderate doses (>0.5 Gy) of ionizing radiation exposure and circulatory system damage, also between radiation and posterior subcapsular cataract. At lower dose correlations with circulatory disease are emerging in the Japanese atomic bomb survivors and in some occupationally exposed groups, and are still to some extent controversial. Heterogeneity in excess relative risks per unit dose in epidemiological studies at low (<0.1 Gy) and at low-moderate (>0.1 Gy, <0.5 Gy) doses may result from confounding and other types of bias, and effect modification by established risk factors. There is also accumulating evidence of excess cataract risks at lower dose and low dose rate in various cohorts. Other ocular endpoints, specifically glaucoma and macular degeneration have been little studied. In this paper, we review recent epidemiological findings, and also discuss some of the underlying radiobiology of these conditions. We briefly review some other types of mainly neurological nonmalignant disease in relation to radiation exposure. Conclusions: We document statistically significant excess risk of the major types of circulatory disease, specifically ischemic heart disease and stroke, in moderate-or low-dose exposed groups, with some not altogether consistent evidence suggesting dose-response non-linearity, particularly for stroke. However, the patterns of risk reported are not straightforward. We also document evidence of excess risks at lower doses/dose-rates of posterior subcapsular and cortical cataract in the Chernobyl liquidators, US Radiologic Technologists and Russian Mayak nuclear workers, with fundamentally linear dose-response. Nuclear cataracts are less radiogenic. For other ocular endpoints, specifically glaucoma and macular degeneration there is very little evidence of effects at low doses; radiation-associated glaucoma has been documented only for doses >5 Gy, and so has the characteristics of a tissue reaction. There is some evidence of neurological detriment following low-moderate dose ($0.1-0.2 Gy) radiation exposure in utero or in early childhood.

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The Risk of Acute Myocardial Infarction and Arterial Hypertension in a Cohort of Male Employees of a Siberian Group of Chemical Enterprises Exposed to Long-Term Irradiation

Cited by 7 publications

References 17 publications

Markers of endothelial dysfunction in patients with arterial hypertension exposed to occupational irradiation of low intensity

Markers of endothelial dysfunction in patients with arterial hypertension exposed to occupational irradiation of low intensity

Biological pathway selection through Bayesian integrative modeling

Low- and moderate-dose non-cancer effects of ionizing radiation in directly exposed individuals, especially circulatory and ocular diseases: a review of the epidemiology

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