“…Ischemia with subsequent skin necrosis mainly occurs in the glabella [6,7], nose [7][8][9][10][11][12], forehead [7,8], nasolabial fold [10], and cheek [13]. Moreover, intracranial artery embolism can lead to blindness caused by retinal artery occlusion and [10,11,13] has been sporadically reported to treat HA embolism-induced skin necrosis [14][15][16][17], however, well-designed case-control studies are required to verify the efficacy and safety of hyaluronidase before it can be used routinely in humans. Because HA injection-induced embolism is a rare complication, creation of an animal model is necessary for thorough study of its pathophysiological progress and potential treatment.…”