The risk of coronary artery disease and cerebrovascular disease in patients with hepatitis C: A systematic review and meta-analysis

Ambrosino, Pasquale; Lupoli, Roberta; Minno, Alessandro Di; Tarantino, L.; Spadarella, Gaia; Tarantino, Paolo; Nasto, Aurelio; Celentano, Aldo; Minno, Matteo Nicola Dario Di

doi:10.1016/j.ijcard.2016.06.337

Cited by 62 publications

(71 citation statements)

References 60 publications

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“…This finding is also consistent with those of studies considering cardiovascular and cerebral events separately, with the cardiovascular events being associated with past infection too . Nevertheless, these results should be taken with caution due to the high heterogeneity of included studies that could not be sufficiently dealt with during analysis .…”

Section: Discussionsupporting

confidence: 88%

“…Unfortunately, the DHS data lacked measurement of lipid and lipoprotein profiles, which limited our ability to adjust for their effect. Recent systematic reviews and large meta‐analyses suggest that CCV events occur with chronic HCV infection status . This finding is also consistent with those of studies considering cardiovascular and cerebral events separately, with the cardiovascular events being associated with past infection too .…”

Section: Discussionsupporting

confidence: 81%

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Association between hepatitis C infection and cerebro‐cardiovascular disease: analysis of a national population‐based survey in Egypt

Gadallah

Kandil

Mohsen

2018

Tropical Med Int Health

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 81%

Association between hepatitis C infection and cerebro‐cardiovascular disease: analysis of a national population‐based survey in Egypt

Gadallah

Kandil

Mohsen

2018

Tropical Med Int Health

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“…In a large meta‐analysis that compared the risk of cardiovascular diseases in 297,613 HCV patients with that in 557,814 uninfected controls, the odds ratio of cardio‐cerebrovascular disease was 1.428 (95% CI: 1.214‐1.681) for HCV patients. A sub‐analysis also demonstrated that HCV infection increased the risk of coronary artery disease (odds ratio: 1.382; 95% CI: 1.103‐1.732) and of cerebrovascular disease (odds ratio: 1.485; 95% CI: 1.079‐2.044) …”

Section: Chronic Hepatitis Viral Infection and Arteriosclerosismentioning

confidence: 92%

Systematic review: chronic viral hepatitis and metabolic derangement

Wang

Cheng

Kao

2019

Aliment Pharmacol Ther

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Summary Background The liver has a critical role in the metabolism of glucose and lipids. Chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection leads to a spectrum of liver disease including chronic hepatitis, cirrhosis and hepatocellular carcinoma. Metabolic syndrome (MetS) has a rising incidence owing to an epidemic of type 2 diabetes mellitus (T2DM) and obesity. Non‐alcoholic fatty liver disease is a liver manifestation of MetS and has become the most common cause of chronic liver disease worldwide. Aim To summarise the interplay among hepatitis viruses, MetS and its components. Methods We searched the literature about HBV, HCV infection, MetS, fatty liver and its components from PubMed. Results With respect to the viral replication cycle, lipids are important mediators between viral entry and hepatocyte in HCV infection, but not in HBV infection. Thus, HCV infection is inversely associated with hyperlipidaemia and lipid rebound occurs following sustained viral response induced by interferon‐based therapy or direct antiviral agents. In addition, HCV infection is positively associated with insulin resistance, hepatic steatosis, MetS and the risk of T2DM and atherosclerosis. In contrast, HBV infection may protect infected subjects from the development of MetS and hepatic steatosis. Accumulating evidence suggests that HBV infection is inversely associated with lipid metabolism, and exhibits no conclusive association with insulin resistance or the risk of T2DM and arteriosclerosis. Conclusions In patients with viral hepatitis and concurrent metabolic diseases, a multidisciplinary approach should be given rather than simply antiviral treatment.

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Section: 3unclassified

“…A infecção pelo VHC representa um fator de risco para a aterosclerose, insuficiência cardíaca e doença cerebrovascular 61,69 . É relatado uma maior mortalidade cardiovascular entre os indivíduos anti-VHC positivos 61,69 . Os estudos sobre a doença arterial coronariana e o VHC têm produzido resultados conflitantes [70][71][72][73][74] .…”

Section: 3unclassified

Efetividade e segurança da terapia tripla com boceprevir ou telaprevir no tratamento da hepatite C crônica genótipo 1 em pacientes atendidos em centros de referência no Brasil

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The risk of coronary artery disease and cerebrovascular disease in patients with hepatitis C: A systematic review and meta-analysis

Cited by 62 publications

References 60 publications

Association between hepatitis C infection and cerebro‐cardiovascular disease: analysis of a national population‐based survey in Egypt

Association between hepatitis C infection and cerebro‐cardiovascular disease: analysis of a national population‐based survey in Egypt

Systematic review: chronic viral hepatitis and metabolic derangement

Efetividade e segurança da terapia tripla com boceprevir ou telaprevir no tratamento da hepatite C crônica genótipo 1 em pacientes atendidos em centros de referência no Brasil

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