The risk of endometriosis by early menarche is recently increased: a meta-analysis of literature published from 2000 to 2020

Lu, Mei-Yin; Niu, Jia-Li; Liu, Bin

doi:10.1007/s00404-022-06541-0

Cited by 11 publications

(6 citation statements)

References 56 publications

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“…Linearity, homoscedasticity, normality, and independence were evaluated via diagnostic plots drawn using the plot() function in R. The analysis was performed in UKB unrelated female participants (8276 women with endometriosis and 194 000 controls). Based on previous knowledge about their association with endometriosis, [13][14][15][16][17][18] 4 models were defined using different sets of covariates (Table 2; eMethods in Supplement 1).…”

Section: Logistic Regression: Phenotype Associationmentioning

confidence: 99%

Epidemiologic and Genetic Associations of Endometriosis With Depression, Anxiety, and Eating Disorders

et al. 2023

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ImportanceEndometriosis is a common chronic gynecologic pathology with a large negative impact on women’s health. Beyond severe physical symptoms, endometriosis is also associated with several psychiatric comorbidities, including depression and anxiety.ObjectiveTo investigate whether pleiotropy contributes to the association of endometriosis with depression, anxiety, and eating disorders.Design, Setting, and ParticipantsThis genetic association study was performed between September 13, 2021, and June 24, 2022, in 202 276 unrelated female participants. Genotypic and phenotypic information from the UK Biobank was combined with genome-wide association statistics available from the Psychiatric Genomics Consortium (11 countries), the Million Veteran Program (US), the FinnGen study (Finland), and the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) consortium (5 countries).Main Outcomes and MeasuresThe main outcomes were the phenotypic and genetic associations of endometriosis with anxiety, depression, and eating disorders.ResultsA total of 8276 women with endometriosis (mean [SD] age, 53.1 [7.9] years) and 194 000 female controls (mean [SD] age, 56.7 [7.9] years) were included in the study. In a multivariate regression analysis accounting for age, body mass index, socioeconomic status, chronic pain–related phenotypes, irritable bowel syndrome, and psychiatric comorbidities, endometriosis was associated with increased odds of depression (odds ratio [OR], 3.61; 95% CI, 3.32-3.92), eating disorders (OR, 2.94; 95% CI, 1.96-4.41), and anxiety (OR, 2.61; 95% CI, 2.30-2.97). These associations were supported by consistent genetic correlations (rg) (depression rg, 0.36, P = 1.5 × 10−9; anxiety rg, 0.33, P = 1.17 × 10−5; and eating disorders rg, 0.61, P = .02). With the application of a 1-sample mendelian randomization, the genetic liabilities to depression and anxiety were associated with increased odds of endometriosis (depression: OR, 1.09; 95% CI, 1.08-1.11; anxiety: OR, 1.39; 95% CI, 1.13-1.65). A genome-wide analysis of pleiotropic associations shared between endometriosis and psychiatric disorders identified 1 locus, DGKB rs12666606, with evidence of pleiotropy between endometriosis and depression after multiple testing correction (z = −9.46 for endometriosis, z = 8.10 for depression, P = 5.56 × 10−8; false discovery rate q = 4.95 × 10−4).Conclusions and RelevanceThese findings highlight that endometriosis is associated with women’s mental health through pleiotropic mechanisms. To our knowledge, this is the first large-scale study to provide genetic and phenotypic evidence of the processes underlying the psychiatric comorbidities of endometriosis.

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Section: Logistic Regression: Phenotype Associationmentioning

confidence: 99%

Epidemiologic and Genetic Associations of Endometriosis With Depression, Anxiety, and Eating Disorders

et al. 2023

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“…Nnoaham et al 25 studied 3805 cases and 9526 controls and reported minimal correlation between them, but this was not significant. Lu et al 24 performed a meta‐analysis of 16 published articles and found that early menarche may be a risk factor for developing endometriosis (OR 1.34, 95% CI 1.16–1.54). Women who have endometriosis are a standard deviation score of 0.16 younger per year of presenting their menarche.…”

Section: Resultsmentioning

confidence: 99%

“…Women who have endometriosis are a standard deviation score of 0.16 younger per year of presenting their menarche. According to one of the most accepted theories about endometriosis, Sampson's theory, an early menarche may be the result of an earlier exposure to retrograde menstrual flow 24 …”

Section: Resultsmentioning

confidence: 99%

“…According to one of the most accepted theories about endometriosis, Sampson's theory, an early menarche may be the result of an earlier exposure to retrograde menstrual flow. 24 In relation to pathologies such as ovarian, endometrial, and breast cancers, Yang et al 35 reported a protective association of epithelial ovarian cancer each year after the woman presented her menarche, (OR 0.81, 95% CI 0.67-0.97, P = 0.026 and OR 0.94, 95% CI 0.90-0.98, P = 0.003). One of the main reasons for this protective factor is explained by the hypothesis of "incessant ovulation".…”

Section: Ta B L E 1 (Continued)mentioning

confidence: 99%

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Age of the onset of menarche and its complications: a literature review

Rivas-Paz

Torres-Mendoza

Torres-Castillo

2023

Intl J Gynecology & Obste

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“… 12 , 48 , 49 The quantification of cumulative risk is further complicated by the increased odds of developing a subsequent SS-RF when one already exists for an individual. For example, endometriosis has been linked to greater odds of having an APO, 50 , 51 , 52 , 53 PCOS, 54 early menopause 39 , 55 associated with early age of menarche, 56 , 57 and breast cancer. 58 , 59 Challenges aside, effective screening involves early identification of risk factors that can be addressed with recommended prevention and or treatment guidelines, with the ultimate goal of improving health outcomes.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Sex-Specific Cardiovascular Disease Risk Factors, Medical Risk, and Engagement in Health-Promoting Behaviours in Premenopausal Females

Szakun,

Liva,

Bodner

et al. 2024

CJC Open

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The risk of endometriosis by early menarche is recently increased: a meta-analysis of literature published from 2000 to 2020

Cited by 11 publications

References 56 publications

Epidemiologic and Genetic Associations of Endometriosis With Depression, Anxiety, and Eating Disorders

Epidemiologic and Genetic Associations of Endometriosis With Depression, Anxiety, and Eating Disorders

Age of the onset of menarche and its complications: a literature review

Prevalence of Sex-Specific Cardiovascular Disease Risk Factors, Medical Risk, and Engagement in Health-Promoting Behaviours in Premenopausal Females

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