The Risk of Gastrointestinal Cancer on Daily Intake of Low-Dose BaP in C57BL/6 for 60 Days

Zheng, Zhi; Park, Jung Kuk; Kwon, Oh Wook; Ahn, Sung Hoon; Kwon, Young Joo; Jiang, Linjuan; Shao-hui, Zhu; Park, Byoung Hee

doi:10.3346/jkms.2022.37.e235

Cited by 11 publications

(4 citation statements)

References 31 publications

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“…Various in vivo and in vitro experiments in human cell lines and rodents had shown that B[a]P induces different downstream processes through the activation of AhR (Almendarez-Reyna et al, 2023; Jin et al, 2022; Lou et al, 2022; Tsai et al, 2015). Subsequently, B[a]P exposure has been observed to induce oxidative stress in cells through increased interleukin 6 (IL-6) production as a result of activated NF-κB signaling pathway (Jin et al, 2022; Malik et al, 2018; Zheng et al, 2022). The oxidative stress caused by B[a]P exposure has been studied as a cause for disruption of lysosomes, eventually leading to dysfunctional autophagy (Gorria et al, 2008; Li et al, 2023).…”

Section: Resultsmentioning

confidence: 99%

“…The copyright holder for this preprint this version posted March 29, 2024. ; https://doi.org /10.1101/2024.03.27.586984 doi: bioRxiv preprint Subsequently, B[a]P exposure has been observed to induce oxidative stress in cells through increased interleukin 6 (IL-6) production as a result of activated NF-κB signaling pathway (Jin et al, 2022;Malik et al, 2018;Zheng et al, 2022). The oxidative stress caused by B[a]P exposure has been studied as a cause for disruption of lysosomes, eventually leading to dysfunctional autophagy (Gorria et al, 2008;Li et al, 2023).…”

Section: Toxicity Pathway Linking B[a]p Exposure To Liver Fibrosis In...mentioning

confidence: 99%

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Leveraging integrative toxicogenomic approach towards development of stressor-centric adverse outcome pathway networks for plastic additives

Sahoo,

Chivukula,

Madgaonkar

et al. 2024

Preprint

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Plastics are widespread pollutants found in atmospheric, terrestrial and aquatic ecosystems due to their extensive usage and environmental persistence. Plastic additives, that are utilized to achieve specific functionality in plastics, leach into the environment upon plastic degradation and pose considerable risk to ecological and human health. Limited knowledge concerning the presence of plastic additives throughout the plastic life cycle has hindered their effective regulation, thereby posing risks to product safety. In this study, we leveraged the adverse outcome pathway (AOP) framework to understand the mechanisms underlying plastic additives-induced toxicities. We first identified an exhaustive list of 6470 plastic additives from chemicals documented to be found in plastics. Next, we leveraged heterogenous toxicogenomics and biological endpoints data from five exposome-relevant resources, and identified associations between 1287 plastic additives and 322 complete and high quality AOPs within AOP-Wiki. Based on these plastic additive-AOP associations, we constructed a stressor-centric AOP network, wherein the stressors are categorized into 10 priority use sectors and AOPs are linked to 27 disease categories. We visualized the plastic additives-AOP network for each of the 1287 plastic additives and made them available in a dedicated website: https://cb.imsc.res.in/saopadditives/. Finally, we showed the utility of the constructed plastic additives-AOP network by identifying 28 highly relevant AOPs associated with benzo[a]pyrene, and thereafter, explored the associated toxicity pathways leading to respiratory and gastrointestinal system diseases in humans and developmental disorders in aquatic species. Overall, the constructed plastic additives-AOP network will enable regulatory risk assessment of plastic additives, thereby contributing towards a toxic-free circular economy for plastics.

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Section: Resultsmentioning

confidence: 99%

Section: Toxicity Pathway Linking B[a]p Exposure To Liver Fibrosis In...mentioning

confidence: 99%

Leveraging integrative toxicogenomic approach towards development of stressor-centric adverse outcome pathway networks for plastic additives

Sahoo,

Chivukula,

Madgaonkar

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…In addition, the quantity and frequency of the food consumed might affect human exposure to HCAs ( 35 ). BaP was shown to induce stomach and liver cancer ( 36 ). In 2006, FAO/WHO claimed that BaP causes tumours of the gastrointestinal tract, liver, lungs, mammary glands and other tissues.…”

Section: Discussionmentioning

confidence: 99%

Risk Assessment of Polycyclic Aromatic Hydrocarbons and Heterocyclic Aromatic Amines in Processed Meat, Cooked Meat and Fish-Based Products Using the Margin of Exposure Approach

Ab-Latif,

Abdullah,

Omar

et al. 2024

MJMS

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Background: The objective of this study is to assess the risk of exposure of polycyclic aromatic hydrocarbons (PAHs) and heterocyclic aromatic amines (HCAs) in meat and fish-based products marketed in Malaysia using the margin of exposure (MOE) approach. Methods: Benchmark Dose (BMD) software was used to model the BMD at a lower end of a one-sided 95% confidence interval with a 10% incremental risk (BMDL10) of PAHs and HCAs from different target organ toxicities. The MOEs of PAHs and HCAs in meat and fish-based products were determined by utilising the calculated BMDL10 values and estimated daily intake of meat and fish-based products from published data. Results: The calculated BMDL10 values of PAHs (i.e. benzo[a]pyrene [BaP] and fluoranthene [FA]) and HCAs (i.e. 2-amino-3,8,dimethylimidazo[4,5-f]quinoxaline [MeIQx] and 2-amino-1-methyl-6-phenylimidazo[4,5,6]pyridine [PhIP]) ranged from 19 mg/kg bw/day to 71,801 mg/kg bw/day. The MOE of BaP ranged from 41,895 to 71,801 and that of FA ranged from 19 to 1412. As for MeIQx and PhIP, their MOEs ranged from 6,322 to 7,652 and from 2,362 to 14,390, respectively. Conclusion: The MOEs of FA, MeIQx and PhIP were lower than 10,000, indicating a high concern for human health and therefore demanding effective risk management actions.

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“…It is generally accepted that changes in intestinal microbiota are associated with human diseases, and the toxic effects of BaP have been widely characterized. 23 However, the effect of BaP on the intestinal tract is uncertain. This study observed that BaP exposure destroyed the gut micro ora of mice, leading to the abnormal in ammatory responses and pyroptotic damage, and changes in intestinal function.…”

Section: Discussionmentioning

confidence: 99%

Benzo[a]pyrene induces pyroptotic colon damage and gut dysbacteriosis by activating Aryl Hydrocarbon Receptor

Jia,

Meng,

Wang

et al. 2024

Preprint

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Benzo[a]pyrene (BaP) is a kind of carcinogenic, teratogenic, and immunotoxic injurant in high-temperature processed foods. Aryl hydrocarbon receptor (AHR) is widely expressed in various cell types throughout the body and initiates cell death through beginning with ligand binding. AHR plays a crucial role in BaP metabolism. In this study, AHR antagonist CH223191 was used to investigate the toxic effects of BaP on colon tissues in mice by activating AHR. The study revealed that BaP led to an increase in the mRNA expression of inflammatory cytokines (TNF- α, IL-1 β, IL-6, and IL-10) and pyroptosis markers (NF-κB, NLRP3, Caspase-1, and GSDMD) in mouse colon tissues by activating AHR. Similarly, BaP caused a decrease in the levels of ZO-1, MUC2, and Occludi. Furthermore, CH223191 showed promise in mitigating the pyroptotic damage to the colon induced by BaP. Notably, BaP altered the gut microbiota by activating AHR, resulting in a reduction in the abundance of several beneficial bacteria genera, such as Lactobacillus, Bacteroides, Alistipes, and Rikenella, following BaP exposure. However, CH223191 was able to effectively reverse this adverse change. In summary, BaP damaged the intestinal barrier, caused pyroptotic colon damage in mice, and altered the gut microbiota by binding to and activating AHR.

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The Risk of Gastrointestinal Cancer on Daily Intake of Low-Dose BaP in C57BL/6 for 60 Days

Cited by 11 publications

References 31 publications

Leveraging integrative toxicogenomic approach towards development of stressor-centric adverse outcome pathway networks for plastic additives

Leveraging integrative toxicogenomic approach towards development of stressor-centric adverse outcome pathway networks for plastic additives

Risk Assessment of Polycyclic Aromatic Hydrocarbons and Heterocyclic Aromatic Amines in Processed Meat, Cooked Meat and Fish-Based Products Using the Margin of Exposure Approach

Benzo[a]pyrene induces pyroptotic colon damage and gut dysbacteriosis by activating Aryl Hydrocarbon Receptor

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