The Risk of Hip Fracture After Initiating Antihypertensive Drugs in the Elderly

Butt, Debra A.; Mamdani, Muhammad; Austin, Peter C.; Tu, Karen; Gomes, Tara; Glazier, Richard H.

doi:10.1001/2013.jamainternmed.469

Cited by 179 publications

(134 citation statements)

References 49 publications

Supporting

Mentioning

113

Contrasting

Unclassified

Order By: Relevance

“…[17][18][19] Therefore, both the benefits (including preserving autonomy) and the risks of antihypertensive therapy should be considered before starting treatment in the very frail older population. This population is the one at the highest risk of not only hypertension-related cardiovascular events but also hypotension-related events.…”

Section: Benefits Of Treatmentmentioning

confidence: 99%

“…This population is the one at the highest risk of not only hypertension-related cardiovascular events but also hypotension-related events. [19][20][21] Hypotension-related events are likely to be more common in real life than in clinical trials in which treatment is delivered by expert physicians and patients are followed up closely. In a recent analysis of a large real-life database, very old individuals showed a significant increase in hospitalizations for hip fracture over the 30 days after initiation of antihypertensive drug treatment.…”

Section: Benefits Of Treatmentmentioning

confidence: 99%

See 1 more Smart Citation

An Expert Opinion From the European Society of Hypertension–European Union Geriatric Medicine Society Working Group on the Management of Hypertension in Very Old, Frail Subjects

et al. 2016

View full text Add to dashboard Cite

Section: Benefits Of Treatmentmentioning

confidence: 99%

Section: Benefits Of Treatmentmentioning

confidence: 99%

An Expert Opinion From the European Society of Hypertension–European Union Geriatric Medicine Society Working Group on the Management of Hypertension in Very Old, Frail Subjects

et al. 2016

View full text Add to dashboard Cite

“…Esses dados estão de acordo com dados de outros autores e provavelmente refletem uma característica importante desses indivíduos, que tendem a passar a maior parte do tempo em suas residências e apresentar outros fatores de risco que se somam -por exemplo, a diminuição da força muscular. 18,19 Por outro lado, a presença de corrimão em escadas nas residências de idosos representou um fator de proteção contra quedas, o que também foi observado em outros estudos. 17 Ao analisar as condições de saúde e morbidades associadas a quedas e fraturas de fêmur, verificou-se que idosos portadores de hipertensão arterial sistêmica (HAS) e em uso de anti-hipertensivos foram mais propensos a sofrer fratura de fêmur, o que pode estar relacionado com o tipo de medicamento utilizado por esses indivíduos.…”

Section: -14unclassified

Análise dos fatores associados a quedas com fratura de fêmur em idosos: um estudo caso-controle

Soares

Mello

Silva

et al. 2015

Rev. bras. geriatr. gerontol.

View full text Add to dashboard Cite

ResumoObjetivo: Identificar os principais fatores associados a quedas e fraturas de fêmur em idosos. Métodos: Trata-se de estudo caso-controle (um grupo de casos e dois grupos controle) na proporção de 1:1:1, em que foram estudados 135 indivíduos com idade ≥60 anos, pareados por sexo, no período de 2005 a 2012. Os dados foram coletados por meio de entrevistas nos domicílios dos participantes, e realizou-se levantamento de informações em prontuários. Para análise das diferenças entre proporções e médias entre os grupos, empregaram-se o teste qui-quadrado e o teste t Student, respectivamente. Para o estudo da associação entre variáveis, foram realizadas análises univariadas e multivariadas empregando-se regressão logística. Como medida de efeito, foram empregados odds ratio (OR) e seu intervalo de confiança a 95% (IC95%). Em todas as análises, considerou-se um nível de significância de 5%. Resultados: Após análise multivariada, os fatores de proteção contra fratura de fêmur foram: ouvir bem e possuir corrimão nas escadas de suas residências. Os fatores de risco para fratura de fêmur foram: hipertensão arterial sistêmica, sedentarismo e possuir superfície escorregadia na residência. Os fatores de proteção para queda foram: possuir corrimão nas escadas de suas residências, ser portador de osteoporose e depressão. O fator de risco de queda foi o sedentarismo. Conclusão: As fraturas de fêmur representam importante fator de morbidade em idosos. Conhecer os fatores de risco para fraturas pós-queda em idosos é essencial para o planejamento de ações individuais e coletivas voltadas à prevenção deste agravo e suas consequências. Atividades físicas, planos terapêuticos mais adequados e correção de inadequações nos domicílios desses indivíduos devem ser orientados e incentivados. Palavras

show abstract

“…A meta-analysis of observational studies in the general population aged 60 years or older pointed out that the use of antihypertensive medication increases the risk of fall (35), and an observational study in a general population of 3544 elderly persons with a median age of 70 years found that the risk of fall increases when the achieved BP value is low (36). On the other hand, among elderly persons, hip fracture is caused by falling in about 80% of cases (37), and an observational study in a general population of 301591 elderly persons with a mean age of 81 years has shown that the risk of hip fracture increased in the initial phase of antihypertensive treatment (38). Among 815 patients aged 75 years or older in the present study, fall and hip fracture each occurred as adverse events in 1 (0.1%) patient.…”

Section: Discussionmentioning

confidence: 99%

Blood pressure control with cilnidipine treatment in Japanese post-stroke hypertensive patients: The CA-ATTEND study

Aoki

Hosomi

Nezu

et al. 2017

Clinical and Experimental Hypertension

View full text Add to dashboard Cite

Blood pressure control is important in post-stroke hypertensive patients and antihypertensive treatment is recommended for such patients. Ca-channel blockers are recommended as the medications of choice for the treatment of post-stroke patients. Here, we report the results of a large-scale prospective postmarketing surveillance study of post-stroke hypertensive patients (n = 2667, male 60.4%, 69.0 ± 10.9 years) treated with cilnidipine, with regard to blood pressure control and adverse reactions. Cilnidipine treatment caused a decrease in both clinic and home blood pressures 2 months after the beginning of treatment, and the decreased blood pressure was maintained until the end of 12 months' observation. The proportion of patients in whom clinic blood pressure was well controlled (<140/90 mmHg) increased from 21.5% to 65.3% in cilnidipine treatment, with no differences in effectiveness among the various clinical subtypes of stroke. In total, 346 adverse events occurred, with an overall incidence of 8.9% (238 of 2667 patients). In the elderly group, specifically, a fall and a hip fracture each occurred in 1 (0.1%) patient. These results indicate that cilnidipine was effective in treating uncontrolled blood pressure and was well tolerated in Japanese post-stroke hypertensive patients in a real-world clinical setting. ARTICLE HISTORY

show abstract

The Risk of Hip Fracture After Initiating Antihypertensive Drugs in the Elderly

Cited by 179 publications

References 49 publications

An Expert Opinion From the European Society of Hypertension–European Union Geriatric Medicine Society Working Group on the Management of Hypertension in Very Old, Frail Subjects

An Expert Opinion From the European Society of Hypertension–European Union Geriatric Medicine Society Working Group on the Management of Hypertension in Very Old, Frail Subjects

Análise dos fatores associados a quedas com fratura de fêmur em idosos: um estudo caso-controle

Blood pressure control with cilnidipine treatment in Japanese post-stroke hypertensive patients: The CA-ATTEND study

Contact Info

Product

Resources

About