The Risk of Immunosuppression: A Case of <i>Salmonella</i> Meningitis

Dower, Joshua; Lerner, David P.; Geva, Tamar; Wener, Kenneth

doi:10.1155/2018/4874575

Cited by 3 publications

(3 citation statements)

References 7 publications

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“…Salmonella clearance is dependent upon macrophage phagocytosis, and in particular tumor necrosis factor inhibitors prevent activation and proliferation of macrophages. Consequently, this diminished activation of an inflammatory response leads to increased risk of disseminated Salmonellosis [ 6 , 9 ]. The identification of this patients DMARD therapy including tumor necrosis factor, adalimumab, as a key contributing factor for his pleuropulmonary salmonellosis was crucial.…”

Section: Discussionmentioning

confidence: 99%

An unusual case of non-typhi pleuropulmonary salmonellosis

Sullivan

Zachariah

Agarwal

et al. 2022

Respiratory Medicine Case Reports

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Section: Discussionmentioning

confidence: 99%

An unusual case of non-typhi pleuropulmonary salmonellosis

Sullivan

Zachariah

Agarwal

et al. 2022

Respiratory Medicine Case Reports

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“…These focal infections are most commonly seen in immunocompromised patients, i.e. HIV positive patients [5] or patients having immune suppressing medication like steroids [7] or tumor necrosis factor antagonist [8] or a previously presumed immunocompetent patient later found as immunosuppression, i.e. AIDS [9].…”

Section: Discussionmentioning

confidence: 99%

Salmonella typhi Meningitis in an Immunocompetent Asian Adult

Nadeem

Elahi

Elhoufi

et al. 2019

Cureus

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Enteric salmonella infections are common in the United States though nonenteric salmonella infections in immunocompetent adults are exceedingly rare in the United States, and meningitis is one of the least common extra-intestinal sites. In addition, it is very unusual for a patient with bacterial meningitis to present with meningitis signs and symptoms of >72 h duration like aseptic meningitis. A 25-year-old Indian male, without any past medical history brought by friends to the ER had fever and irritability for a week. He became increasingly somnolent and confused three days back. Physical exam reveals signs of meningitis and laboratory showed cerebrospinal fluid (CSF) studies suggestive of bacterial meningitis. Culture of CSF grew Salmonella typhi and later on blood culture also grew S. typhi. The patient became worse with cerebral edema and hydrocephalous suspected by change in neurological status and confirmed by ultrasound of eye ball examining optic nerve sheath diameter and CT scan of brain. The patient required neurosurgical intervention and hence external ventricular drain was placed. The patient was also placed on mechanical ventilation. Subsequently he developed ventilator associated pneumonia (VAP) with carbapenem-resistant Pseudomonas aeruginosa. The patient underwent tracheostomy and successfully completed treatment of VAP and was transferred to his home country after four months. Thus we describe a rare case of salmonella meningitis in an immunocompetent adult.

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“…But, when compared with other Gram-negative bacteria, nontyphoidal Salmonella is a less common etiologic factor for septic arthritis [7] . However, underlying states such as malignancy, hemoglobinopathy, diabetes, human immunodeficiency virus (HIV) infection, surgical operations, and other immune suppressive conditions predispose a patients to Salmonella arthritis [8] . In this report, we describe a case of bilateral hip septic arthritis due to nontyphoidal Salmonella after COVID-19 in a young patient with acute lymphocytic leukemia (ALL).…”

Section: Introductionmentioning

confidence: 99%