The risk of nontuberculous mycobacterial infection in patients with Sjögren’s syndrome: a nationwide, population-based cohort study

Chao, Wen‐Cheng; Lin, Ching‐Heng; Liao, Tsai‐Ling; Chen, Yiming; Hsu, Chiann‐Yi; Chen, Junpeng; Chen, Der‐Yuan; Chen, Hsin‐Hua

doi:10.1186/s12879-017-2930-7

Cited by 16 publications

(8 citation statements)

References 34 publications

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“…The coexistence between NTM disease and chronic heart failure, GERD, other cancer, and rheumatoid arthritis has been reported previously [8,9,16]. Chao et al [23] reported an increased risk of NTM [24]. NTM-LD may be an underlying condition in patients with Sjögren syndrome because some patients with Sjögren syndrome have been reported to develop bronchiectasis [25,26], and pulmonary involvement in patients with Sjögren syndrome can be difficult to distinguish from NTM-LD using CT.…”

Section: Discussionmentioning

confidence: 93%

“…The coexistence between NTM disease and chronic heart failure, GERD, other cancer, and rheumatoid arthritis has been reported previously [ 8 , 9 , 16 ]. Chao et al [ 23 ] reported an increased risk of NTM disease in patients with Sjögren syndrome based on an analysis of Taiwan’s National Health Insurance Research Database analysis. Pulmonary abnormalities have been described as an extra-glandular involvement of Sjögren syndrome [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

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Comorbidities associated with nontuberculous mycobacterial disease in Japanese adults: a claims-data analysis

et al. 2020

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Background Nontuberculous mycobacterial (NTM) lung disease is one of a growing number of chronic health problems that is difficult to cure in aging societies. While it is important to be vigilant about associated comorbidities in order to provide better patient care, data on the prevalence of comorbidities stratified by country or region are scarce. We aimed to elucidate the comorbidities associated with NTM disease based on Japanese health insurance claims data. Methods Cross-sectional analyses were performed using the claims data for 2014 provided by the Japan Medical Data Center Co., Ltd. Patients aged 20–75 years with ≥3 claims associated with NTM disease were identified and matched to 10 sex-and-age-matched controls that had never made a claim for NTM disease. Thirty-one comorbidities previously suspected to be associated with NTM disease were selected, and the prevalence of these comorbidities compared between cases and controls. Result Overall, 419 NTM patients (134 males and 285 females) and 4190 non-NTM controls were identified from the JMDC database. Aspergillosis, asthma, chronic heart failure, diffuse panbronchiolitis, gastroesophageal reflux, interstitial pneumonia, lung cancer, cancer other than breast, lung, ovary, or prostate cancer, and rheumatoid arthritis were associated with NTM disease in both males and females. Chronic obstructive pulmonary disease was associated with NTM in males while chronic kidney disease, osteoporosis, and Sjögren syndrome were associated with NTM in females. Conclusion NTM disease was associated with multiple comorbidities that should be considered when providing medical care to individuals with NTM disease.

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Section: Discussionmentioning

confidence: 93%

“…The coexistence between NTM disease and chronic heart failure, GERD, other cancer, and rheumatoid arthritis has been reported previously [ 8 , 9 , 16 ]. Chao et al [ 23 ] reported an increased risk of NTM disease in patients with Sjögren syndrome based on an analysis of Taiwan’s National Health Insurance Research Database analysis. Pulmonary abnormalities have been described as an extra-glandular involvement of Sjögren syndrome [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Comorbidities associated with nontuberculous mycobacterial disease in Japanese adults: a claims-data analysis

et al. 2020

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“…Finally, in a recent study among persons living in Taiwan and with Sjögren's syndrome, a systemic chronic inflammatory disorder characterized by lymphocytic infiltrates in the exocrine glands, those treated with immunosuppressants were 25 times more likely to have an incident NTM infection than those treated without immunosuppressants. 26…”

Section: Pntm Prevalence In High-risk Populationsmentioning

confidence: 99%

Epidemiology of Nontuberculous Mycobacteriosis

Adjemian

Daniel-Wayman

Ricotta

et al. 2018

Semin Respir Crit Care Med

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Annual prevalence estimates for pulmonary nontuberculous mycobacterial (PNTM) disease in the contiguous United States range from 1.4 to 13.9 per 100,000 persons, while one study found an annual prevalence of up to 44 per 100,000 persons in Hawaii. PNTM prevalence varies by region, sex, and race/ethnicity, with higher prevalence among women and persons of Asian ancestry, as well as in the Southern United States and Hawaii. Studies consistently indicate that PNTM prevalence is increasing, with estimates ranging from 2.5 to 8% per year. Most PNTM disease is associated with complex (MAC), although the proportion of disease attributed to MAC varies by region. Host factors identified as influencing disease risk include structural lung disease, immunomodulatory medication, as well as variants in connective tissue, mucociliary clearance, and immune genes. Environmental variables including measures of atmospheric moisture and concentrations of certain soil factors have also been shown to correlate with higher PNTM prevalence. Prevalence of extrapulmonary NTM disease is lower, stable, and associated with different risk factors, including primary immune deficiencies or HIV infection.

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“…The coexistence between NTM disease and chronic heart failure, GERD, other cancer, and rheumatic arthritis has been reported previously [8,9,16]. Chao et al [28] reported an increased risk of NTM disease in patients with Sjögren syndrome based on an analysis of Taiwan's National Health Insurance Research Database analysis. Pulmonary abnormalities have been described as an extra-glandular involvement of Sjögren syndrome [29].…”

Section: Discussionmentioning

confidence: 72%

Comorbidities associated with nontuberculous mycobacterial disease in Japanese adults: A claims-data analysis

Uno

Aasakura

Morimoto

et al. 2020

Preprint

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Background Nontuberculous mycobacterial (NTM) lung disease is one of a growing number of chronic health problems that is difficult to cure in aging societies. While it is important to be vigilant about associated comorbidities in order to provide better patient care, data on the prevalence of comorbidities stratified by country or region are scarce. We aimed to elucidate the comorbidities associated with NTM disease based on Japanese health insurance claims data. Methods Cross-sectional analyses were performed using the claims data for 2014 provided by the Japan Medical Data Center Co., Ltd. Patients aged 20–75 years with ≥ 3 claims associated with NTM disease were identified and matched to 10 sex-and-age-matched controls that had never made a claim for NTM disease. Thirty-one comorbidities previously suspected to be associated with NTM disease were selected, and the prevalence of these comorbidities compared between cases and controls. Result Overall, 419 NTM patients (134 males and 285 females) and 4190 non-NTM controls were selected from the JMDC database. Aspergillosis, asthma, bronchiectasis, chronic heart failure, diffuse panbronchiolitis, gastroesophageal reflux, interstitial pneumonia, lung cancer, cancer other than breast, lung, ovary, or prostate cancer, and rheumatic arthritis were associated with NTM disease in both males and females. Chronic obstructive pulmonary disease was associated with NTM in males while chronic kidney disease, osteoporosis, and Sjögren syndrome were associated with NTM in females. Conclusion NTM disease was associated with multiple comorbidities that should be considered when providing medical care to individuals with NTM disease.

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The risk of nontuberculous mycobacterial infection in patients with Sjögren’s syndrome: a nationwide, population-based cohort study

Cited by 16 publications

References 34 publications

Comorbidities associated with nontuberculous mycobacterial disease in Japanese adults: a claims-data analysis

Comorbidities associated with nontuberculous mycobacterial disease in Japanese adults: a claims-data analysis

Epidemiology of Nontuberculous Mycobacteriosis

Comorbidities associated with nontuberculous mycobacterial disease in Japanese adults: A claims-data analysis

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