The Risk of Osteoporotic Forearm Fractures in Postmenopausal Women in a Siberian Population Sample

Abstract

The reduction in bone and muscle mass increases in menopausal women and poses a threat to the loss of self-dependence in the elderly. The aim of the study was to assess the frequency of osteoporotic forearm fractures (OFF) in postmenopausal women and to study their association with risk factors for chronic non-communicable diseases (NCD). The study was based on the Russian arm of the Health, Alcohol and Psychosocial Factors In Eastern Europe (HAPIEE) project (Novosibirsk). In a subsample of postmenopausal women aged 55–84 years old (n = 2005), we assessed the history of OFF during the last 3 years and risk factors for fracture and common NCD/. Cross-sectional associations between OFF history and potential determinants were analyzed using multivariable-adjusted logistic regression. A history of OFF in the last 3 years was found in 3.9% women. In a multivariable-adjusted model, the risk of OFF was directly associated with smoking in the past (OR = 2.23; 95% Cl 1.10–4.55), total cholesterol level higher than 200 mg/dL (OR = 1.98; 95% Cl 1.19–3.29), and it was inversely associated with body mass index (OR = 0.91; 95% Cl 0.86–0.96). In studied population sample of postmenopausal women the cross-sectional determinants of osteoporotic forearm fractures were smoking in the past and high total cholesterol value; body mass index protectively related to the risk of osteoporotic fractures. These findings might have implications for fracture prevention in postmenopausal women.

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“…Serious trauma suffered as a result of vehicle accidents or falls from heights in which a large amount of energy is involved often results in fractures in which bones are multifragmentary. Also, bone density disorders may lead to an increase in the probability of unexpected fractures [ 1 ], or the association between bone and muscle tissue reduction with risk factors for some chronic diseases [ 2 ]. Even if personalized web-based predictive tools in orthopedic surgery are becoming increasingly available [ 3 ], fractures are often difficult to detect and analyze on film scans.…”

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“…Mazurenko et al [ 10 ] examined the frequency of osteoporotic forearm fractures in postmenopausal women to assess their association with risk factors of chronic noncommunicable diseases. In the studied population sample of postmenopausal women, a high total cholesterol level and a history of smoking were cross-sectional determinants of osteoporotic forearm fractures, whereas the body–mass index was a protective factor against the risk of osteoporotic fractures.…”