The risk of second primary tumors in head and neck cancer: A systematic review

Coca‐Pelaz, Andrés; Rodrigo, Juan P.; Suárez, Carlos; Nixon, Iain J.; Mäkitie, Antti; Sanábria, Álvaro; Quer, Miquel; Strojan, Primož; Bradford, Carol R.; Kowalski, Luiz Paulo; Shaha, Ashok R.; Bree, Remco de; Hartl, Dana M.; Rinaldo, Alessandra; Takes, Robert P.; Ferlito, Alfio

doi:10.1002/hed.26016

Cited by 58 publications

(58 citation statements)

References 82 publications

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“…According to literature, our study confirmed that SPT are common in patients with HNSCC and the may cause a reduced life expectancy in head and neck cancer patients (Coca‐Pelaz et al., 2020).…”

Section: Discussionsupporting

confidence: 84%

Second primary tumors in head and neck cancer patients: The importance of a “tailored” surveillance

et al. 2020

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Objective Head and neck cancer survivors have increased risk of developing second primary tumors compared to overall population. Because second primary represents a major cause of morbidity and mortality in this population, early detection is fundamental. Materials and Methods In this 10‐year single‐institution study, we investigated the following: incidence, clinical‐pathological risk factors, and survival of patients with second primary tumor. We included all patients with diagnosis of squamous cell carcinoma of the head and neck seen at the Modena University Hospital from 2008 to 2018. Results Among 1,177 patients included, 222 (18.9%) developed second primary tumor; its survival probability at 5 years was 40.6%. Alcohol consumption (p = .0055) and index cancer in oropharynx (p = .0029), supraglottic larynx (p = .0000), glottic larynx (p = .0222) were associated with higher risk of second primary. The most common second primary sites were head and neck district and lung (70, 31.5%, and 67, 30.2%, respectively). Head and neck district were more common in oral cavity (18, 43%) and oropharynx index cancer (20, 31%); lung second primary in hypopharynx (4, 40%), supraglottic larynx (17, 43%), and glottic larynx index cancer (23, 35%). Conclusion Head and neck cancer survivors developing a second primary tumor have dismal prognosis. Tailored surveillance is recommended.

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Section: Discussionsupporting

confidence: 84%

Second primary tumors in head and neck cancer patients: The importance of a “tailored” surveillance

et al. 2020

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“…The presence of a previous or synchronous cancer halves survival . Patients with cancer clearly are at a higher risk of developing a second primary cancer …”

Section: Tumor Factorsmentioning

confidence: 99%

Prognostic factors in laryngeal squamous cell carcinoma

Bradford

Ferlito²,

Devaney

et al. 2020

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Background The current treatment results of laryngeal squamous cell carcinoma still remain modest. Various prognostic factors have been investigated and need to be included in the management decision making. Methods We reviewed the pertinent literature regarding host, tumor, and treatment factors as prognostic indicators that influence outcome in patients diagnosed with laryngeal squamous cell carcinoma. Results Host, tumor, and treatment factors all have an important impact upon an individual patient's prognosis with laryngeal squamous cell carcinoma, whereas staging systems only take into account tumor factors. There is much work yet to be done to establish reliable, independent biomarkers that predict survival and response to treatment. Conclusions Optimal outcomes for an individual patient can be achieved when taking into account tumor, host, and treatment factors.

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“…Because HNSCC is related to lifestyle behavior that give rise to disease of multiple organs, this might explain the higher odds of patients having mild to severe liver disease as well as non-metastatic and metastatic malignancy that was observed in this study ( Table 2 ). Previous findings have shown tumors of lung and esophagus to be the most common secondary primary tumor in HNSCC patients apart from tumors in the head and neck region ( 30 ). In correlation with this, we found that patients had almost three times higher odds of having a cancer of the respiratory and intrathoracic organs at diagnosis.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Comorbidity on Survival in Patients With Head and Neck Squamous Cell Carcinoma: A Nationwide Case-Control Study Spanning 35 Years

et al. 2021

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BackgroundComorbidity is presumed to impact survival of head and neck squamous cell cancer (HNSCC) patients. However, the prevalence and prognostic impact of comorbidity in these patients is not yet well established. The aim of this study is to outline the comorbidity burden of HNSCC patients and investigate the relation to overall survival and cancer-specific mortality.MethodsThe comorbidity burden of patients registered with HNSCC in the Danish Cancer Registry between 1980 and 2014 was evaluated based on the Charlson Comorbidity Index (CCI). Patients’ risks of comorbid conditions compared to age- and gender-matched controls were estimated by odds ratios (OR). The impact of comorbidity on overall survival and cancer-specific mortality was evaluated by Cox regression and Kaplan-Meier survival analysis.ResultsA total of 25,388 HNSCC patients were included (72.5% male; mean age 63.2 years at diagnosis; median follow-up 3.0 years). CCI at diagnosis was significantly higher in patients compared to controls (p < 0.001). The most common comorbid conditions among the patients were additional non-metastatic malignancy (10.9%) and cerebrovascular disease (7.7%). Compared to controls, patients had higher odds of metastatic malignancy (OR: 4.65; 95% CI: 4.21–5.15; p < 0.001), mild liver disease (OR: 6.95; 95% CI: 6.42–7.53; p < 0.001), and moderate-severe liver disease (OR: 7.28; 95% CI: 6.14–8.65; p < 0.001). The multivariate Cox analysis revealed increasing hazard ratios with increasing CCI and in coherence the Kaplan-Meier curves showed poorer overall survival and increased cancer-specific mortality in patients with higher CCI.ConclusionHNSCC patients’ comorbidity burden was significantly greater compared to the general population and increased comorbidity was correlated with increased cancer-related mortality.

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The risk of second primary tumors in head and neck cancer: A systematic review

Cited by 58 publications

References 82 publications

Second primary tumors in head and neck cancer patients: The importance of a “tailored” surveillance

Second primary tumors in head and neck cancer patients: The importance of a “tailored” surveillance

Prognostic factors in laryngeal squamous cell carcinoma

The Impact of Comorbidity on Survival in Patients With Head and Neck Squamous Cell Carcinoma: A Nationwide Case-Control Study Spanning 35 Years

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