The Risk of Type 2 Diabetes Mellitus in a Russian Population Cohort According to Data from the HAPIEE Project

Мустафина, С. В.; Rymar, O. D.; Щербакова, Л. В.; Verevkin, Evgeniy G.; Pikhart, Hynek; Sazonova, Olga V.; Ragino, Y.; Simonova, Galina; Bobák, Martin; Malyutina, Sofia; Воевода, М. И.

doi:10.3390/jpm11020119

Cited by 13 publications

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“…Additional data increase the complexity of the analysis, but more data, especially linked data, are needed to provide better research results on associations between metabolic and other disorders. In this light, the era of machine learning and data mining can be an efficient tool to achieve more accurate patient-specific risk factor assessment and diagnosis [76,77], disease risk prediction [78][79][80][81], and appropriate drug selection for the patient's specific disease [82,83]. In the context of personalized medicine, patient-specific treatment should not only consider and evaluate average values [84].…”

Section: Discussionmentioning

confidence: 99%

Age-Related Changes in Lipid and Glucose Levels Associated with Drug Use and Mortality: An Observational Study

Markovič

Grubelnik

Vošner

et al. 2022

JPM

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Background: The pathogenesis of type 2 diabetes mellitus is complex and still unclear in some details. The main feature of diabetes mellitus is high serum glucose, and the question arises of whether there are other statistically observable dysregulations in laboratory measurements before the state of hyperglycemia becomes severe. In the present study, we aim to examine glucose and lipid profiles in the context of age, sex, medication use, and mortality. Methods: We conducted an observational study by analyzing laboratory data from 506,083 anonymized laboratory tests from 63,606 different patients performed by a regional laboratory in Slovenia between 2008 and 2019. Laboratory data-based results were evaluated in the context of medication use and mortality. The medication use database contains anonymized records of 1,632,441 patients from 2013 to 2018, and mortality data were obtained for the entire Slovenian population. Results: We show that the highest percentage of the population with elevated glucose levels occurs approximately 20 years later than the highest percentage with lipid dysregulation. Remarkably, two distinct inflection points were observed in these laboratory results. The first inflection point occurs at ages 55 to 59 years, corresponding to the greatest increase in medication use, and the second coincides with the sharp increase in mortality at ages 75 to 79 years. Conclusions: Our results suggest that medications and mortality are important factors affecting population statistics and must be considered when studying metabolic disorders such as dyslipidemia and hyperglycemia using laboratory data.

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Section: Discussionmentioning

confidence: 99%

Age-Related Changes in Lipid and Glucose Levels Associated with Drug Use and Mortality: An Observational Study

Markovič

Grubelnik

Vošner

et al. 2022

JPM

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“…Мустафина и соавт. провели оценку факторов риска СД2 у мужчин и женщин с помощью многомерных моделей риска развития СД2, что позволило выявить существенные факторы риска и прямые превентивные меры по их устранению [13].…”

Section: оригинальное исследованиеunclassified

Association of polymorphisms of genes SLC30A8 and MC4R with the prognosis of the development of type 2 diabetes mellitus

et al. 2022

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BACKGROUND: The prevalence of Type 2 diabetes mellitus (T2DM) has reached epidemic proportions and it is estimated to affect over 400 million people worldwide. Moreover, the incidence of diabetes is expected to continue to rise and it is projected to affect nearly one of the three individuals by the year 2050. These alarming projections suggest that there is an urgent need for the development and implementation of novel prevention and treatment strategies to combat the rise in T2DM.AIM: To study the possibility of using polymorphisms of genes SLC30A8 and MC4R as markers for predicting the development of T2D in the population of Novosibirsk.MATERIALS AND METHODS: On the basis of prospective follow-up of a representative population sample of residents of Novosibirsk (The HAPIEE Project), 2 groups were formed according to the “case-control” principle (case — people who had diabetes mellitus 2 over 10 years of follow-up, and control — people who did not developed disorders of carbohydrate metabolism). T2D group (n = 443, mean age 56.2 ± 6.7 years, men — 29.6%, women — 70.4%), control group (n = 532, mean age 56.1 ± 7.1 years, men — 32.7%, women — 67.3%). DNA was isolated by phenol-chloroform extraction. Genotyping was performed by the method of polymerase chain reaction with subsequent analysis of restriction fragment length polymorphism, polymerase chain reaction in real time. Statistical processing was carried out using the SPSS 16.0 software package.RESULTS: Genotype TT rs13266634 of the SLC30A8 gene was associated with the risk of developing T2D (relative risk — RR 1.51, 95% confidence interval — CI 1.11–2.05, p =0.008). The CC genotype rs13266634 of the SLC30A8 gene was associated with a protective effect against T2D (RR 0.57, 95% CI 0.35–0.92, p=0.026). No significant effect of rs17782313 of the MC4R gene on the risk of developing T2D was found.CONCLUSION: The rs13266634 polymorphism of the SLC30A8 gene confirmed its association with the prognosis of the development of T2D, which indicates the possibility of considering it as a candidate for inclusion in a diabetes risk score. The association between polymorphisms rs17782313 of the MC4R gene and the prognosis of the development of T2D was not found.

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“…В частности, трехкратное увеличение распространенности МС связано с двукратным увеличением риска смерти от сердечно-сосудистых заболеваний, увеличением общей смертности на 150 % и пятикратным увеличением риска сахарного диабета [3]. Поскольку МС связан с повышенным риском сахарного диабета и сердечно-сосудистых заболеваний [3,4], его ранняя диагностика и коррекция факторов риска могут помочь уменьшить частоту последних.…”

Section: Introductionunclassified

Leptin and cardiometabolic risk factors in overweight persons in young age

Мустафина

Денисова

Alferova

et al. 2021

jour

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Цель исследования: изучить ассоциации уровня лептина с кардиометаболическими факторами риска у лиц молодого возраста с избыточной массой тела. Материал и методы. Из репрезентативной выборки молодого населения Октябрьского района г. Новосибирска в возрасте 25-35 лет (636 человек) выделены лица с избыточной (196 человек) и нормальной массой тела (197 человек, группа контроля), в сыворотке крови которых определяли содержание лептина (393 человека). Дизайн исследования -«случай -контроль». Избыточная масса тела определялась при индексе массы тела (ИМТ) ≥ 25 кг/м 2 . Уровень лептина измеряли методом иммунофлуоресцентного анализа с помощью тест-систем Elisa (Diagnostics Biochem Canada Inc., Canada) на анализаторе Multiskan EX (Thermo Fisher Scientific, Финляндия). Для расчетов использовались медиана и интерквартильный размах (Me [25; 75]). результаты. Концентрация лептина в группе лиц с ИМТ ≥ 25 кг/м 2 была в 4 раза больше, чем в группе контроля (17,0 [8,6; 36,9] и 4,4 [1,5; 13,1] нг/мл соответственно). Проанализированы показатели факторов риска в квартилях лептина: выявлено, что у мужчин и женщин, вошедших в Q4 по содержанию лептина, были больше, чем у вошедших в Q1, окружность талии, окружность бедер, ИМТ, артериальное давление, концентрация триглицеридов; также у них отмечено увеличение частоты метаболического синдрома и снижение уровня холестерина липопротеинов высокой плотности. Кроме того, у мужчин, в отличие от женщин, в Q4 лептина выявлено возрастание концентрации общего холестерина и холестерина липопротеинов низкой плотности. По данным ROC-анализа с высоким уровнем лептина крови ассоциированы все изученные антропометрические параметры, отражающие избыточный вес, а максимальные ассоциации установлены между ожирением II степени (ИМТ более 35 кг/м 2 ) и нормальной массой телаплощадь под ROC-кривой 0,91, р < 0,001. Пороговое значение содержания лептина для выявления метаболического синдрома у мужчин составляет 6,5 нг/мл, у женщин -25,8 нг/мл. заключение. Уровень лептина в сыворотке крови ассоциирован с кардиометаболическими факторами риска и метаболическим синдромом, а концентрация лептина более 6,5 нг/мл у мужчин и 25,8 нг/мл у женщин характерна для лиц с метаболическим синдромом.

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The Risk of Type 2 Diabetes Mellitus in a Russian Population Cohort According to Data from the HAPIEE Project

Cited by 13 publications

References 40 publications

Age-Related Changes in Lipid and Glucose Levels Associated with Drug Use and Mortality: An Observational Study

Age-Related Changes in Lipid and Glucose Levels Associated with Drug Use and Mortality: An Observational Study

Association of polymorphisms of genes SLC30A8 and MC4R with the prognosis of the development of type 2 diabetes mellitus

Leptin and cardiometabolic risk factors in overweight persons in young age

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