The risk reduction of recurrent periodontal pathogens of local application minocycline HCl 2% gel, used as an adjunct to scaling and root planing for chronic periodontitis treatment

Abstract

BackgroundThe aim of this study was to evaluate the clinical and microbiological effects of local application minocycline HCl 2% gel, used as an adjunct to scaling and root planing (SRP) for treatment of chronic periodontitis (CP). CP is an inflammation of periodontal tissue that is caused mainly by bacterial infection, where periodontal destruction such as loss of attachment and bone destruction occurred.MethodsA total of 81 subjects with moderate to severe periodontitis whose baseline clinical attachment loss (CAL) was ≥4 mm were randomly assigned to receive SRP alone (control group, N=39) or SRP followed by four times of local application of minocycline HCl gel (Periocline) once a week (test group, N=42). Pocket depth, CAL, and papilla bleeding index were examined at baseline, 21 days, 2, 3, and 6 months. Subgingival plaque samples were collected with sterile curettes and were analyzed by real-time polymerase chain reaction for the presence of three periodontal pathogens (Porphyromonas gingivalis [P.g.], Tannerella forsythia [T.f.], and Treponema denticola [T.d.]) at baseline, 2, 3, and 6 months.ResultsThe number of bacteria was reduced in both groups at 2 months after baseline (SRP treatment). The changes (2–6 months) in T.d. and T.f. counts in the test group were significantly lower than those in the control group. In the control group, a significant regrowth of P.g., T.f., and T.d. was observed from 2 to 6 months and of P.g. and T.f. from 3 to 6 months. On the other hand, in the test group, the number of the three bacteria did not significantly increase during the 6-month period.ConclusionThe results showed that local application of minocycline, used as an adjunct to SRP, was effective for suppressing regrowth of periodontal pathogens, suggesting its risk reduction of recurrent periodontal pathogens in CP.

<i>In vitro</i> bone sialoprotein-I expression in combined gingival stromal cells and platelet rich fibrin during osteogenic differentiation

“…Periodontal disease constitutes the second most prevalent dental health problem in Indonesia after caries and malocclusion. In 2013, Basic National Health Research Department (RISKESDAS) reported the prevalence of periodontal disease as having reached 96.58 %, thereby representing the second most common oral and dental condition in Indonesia [2][3][4]. Numerous previous studies relating to dentistry have analyzed the relationship between bacterial activity and inflammation resulting from periodontal disease which lead to problematic alveolar bone defects [5].…”

BDNF/HMW‐HA complex as an adjunct to nonsurgical periodontal treatment of ligature‐induced periodontitis in dogs

“…Various therapeutic strategies have been proposed to improve the result of SRP and subsequently avoid the need of surgical periodontal interventions. The local application of minocycline in the treatment of periodontitis as an adjunct to SRP was effective for suppressing regrowth of periodontal pathogens, suggesting risk reduction of recurrent periodontal pathogens compared with SRP alone . Eick et al.…”

“…The local application of minocycline in the treatment of periodontitis as an adjunct to SRP was effective for suppressing regrowth of periodontal pathogens, suggesting risk reduction of recurrent periodontal pathogens compared with SRP alone. 13 Eick et al indicated possible antibacterial effects of high molecular weight hyaluronic acid (HMW-HA) on periodontopathogenic bacteria as an adjunct to SRP and possibly increased reduction in PPD. 14 Though the above approaches showed antimicrobial effects, they cannot regulate periodontal cell functions to enhance periodontal tissue regeneration.…”

Clinical and microbiological effects of adjunctive local delivery of minocycline (Periocline®) in patients receiving supportive periodontal therapy: a pilot study

“…As a semi-synthetic derivative of tetracycline, minocycline has a wide spectrum of action against anaerobic and aerobic bacteria [ 8 ]. A sustained-action formulation of minocycline, as a 2% ointment, has been investigated for subgingival use [ 9 ].…”