The Risks of Corneal Surface Damage in Aqueous-Deficient Dry Eye Disease: A 17-Year Population-Based Study in Taiwan

Hung, Ning; Kang, Eugene Yu-Chuan; Lee, Tay-Wey; Chen, Tien-Hsing; Shyu, Yu-Chiau; Sun, Chi-Chin

doi:10.1016/j.ajo.2021.03.013

Cited by 17 publications

(13 citation statements)

References 43 publications

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“…Previous studies had investigated the prevalence of DED and relevant risk factors in patients with DM. The results regarding the prevalence of DED in patients with DM varied from studies, ranging from 15 to 54.3% (5,(25)(26)(27). Reported risk factors included but were not limited to advanced age, female sex, smoking, higher glycated hemoglobin (HbA1c) level, and DM retinopathy (3,4,16,28,29).…”

Section: Introductionmentioning

confidence: 99%

Dry eye disease in patients with type II diabetes mellitus: A retrospective, population-based cohort study in Taiwan

et al. 2022

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PurposeTo investigate the risk and protective factors of dry eye disease (DED) in patients with type II diabetes mellitus (DM).DesignA retrospective cohort study using Chang- Gung research database collecting data from 2005 to 2020.MethodsPatients with type II DM were included, and those with previous ocular diseases were excluded. Ten thousand twenty nine developed DED (DED group), and 142,491 didn't (non-DED group). The possible risk and protective factors were compared and analyzed using the logistic regression model.ResultsA majority of the DED group were female with significantly higher initial and average glycated hemoglobin levels, and higher incidence of diabetic neuropathy and retinopathy. In conditional logistic regression model, advanced age was a risk factor. After adjusting for sex, age, and DM duration; average glycated hemoglobin level, diabetic neuropathy, retinopathy, and nephropathy with eGFR 30 ~ 59 and intravitreal injection, vitrectomy, pan-retinal photocoagulation, and cataract surgery were contributing factors of DED. Considering antihyperglycemic agents, DPP4 inhibitor, SGLT2 inhibitor, GLP-1 agonist, and insulin monotherapy and dual medications combining any two of the aforementioned agents were protective factors against DED compared with metformin alone. In the monotherapy group, SLGT2 inhibitor had the lowest odds ratio, followed by GLP1 agonist, DPP4 inhibitor, and insulin.ConclusionsDED in patients with DM is associated with female sex, advanced age, poor diabetic control, microvascular complications and receiving ocular procedures. GLP-1 agonist, SGLT-2 inhibitor, DPP4 inhibitor, and insulin are superior to metformin alone in preventing DM-related DED. A prospective randomized control trial is warranted to clarify our results.

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Section: Introductionmentioning

confidence: 99%

Dry eye disease in patients with type II diabetes mellitus: A retrospective, population-based cohort study in Taiwan

et al. 2022

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“…The prevalence of dry eye symptoms has increased among school children over the past two decades [ 7 – 9 ], possibly due to a rise in screen exposure when interacting with the internet and social media. Prolonged screen use can cause dry eye symptoms by decreasing the blink rate and drying the ocular surface through evaporation [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and associated factors for self-reported symptoms of dry eye among Thai school children during the COVID-19 outbreak

et al. 2023

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Purpose COVID-19 pandemic caused an increase in digital screen time, which seemed to increase the prevalence of dry eye symptoms among the population with abnormally high digital screen usage hours. However, there are no reports of dry eye symptoms in school children with high digital usage hours. Therefore, the present study aimed to assess the prevalence of dry eye symptoms and evaluate the associated factors among school children aged 12 to 18 years during the COVID-19 outbreak. Methods Multistage cluster sampling was applied, and six sections of online questionnaires were distributed to selected respondents in November 2021. The odds ratio (OR) with confidence intervals (CIs) for the factors was calculated using binary logistic regression. All statistical significance was determined at p < 0.05. Results The findings revealed that 62.5% of 603 students showed symptoms of dry eye (DEQ-5 score ≥ 6). Significant associated factors included being female (adjusted OR (aOR) 1.54; 95% CIs 1.05–2.25), higher-grade student (aOR 1.77; 95% CIs 1.23–2.57), digital screen time use (6 to < 12 hours: aOR 2.00; 95% CIs 1.12–3.57, ≥12 hours: aOR 2.54; 95% CIs 1.39–4.76), and perceived stress (aOR 1.12; 95% CIs 1.08–1.16). The Thai-Perceived Stress Scale-10 scores were positively correlated with the scores on the 5-item dry eye questionnaire (Spearman’s r = 0.38, p-value < 0.01). Conclusion A high prevalence of dry eye symptoms might be common among school children during the COVID-19 outbreak. Significant risk factors include being female, being a higher-grade level student, prolonged use of digital screens, and perceived stress. However, contact lens use, smoking, and the most common digital device usage patterns were not found to be contributing factors.

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“…Our meta-analysis revealed a significant, near-equivalent decrease in Schirmer test scores with or without anesthesia in the PD cohort, supporting the hypothesis that PD induces decreases in both baseline and reflex lacrimation 16 . Moreover, the aqueous-deficient subtype of DED is associated with increased severity due to elevated friction between the corneal surface and palpebral conjunctiva 61 . Therefore, early intervention may be necessary to prevent visual impairment, as well as resultant cognitive and motor function decline.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and characteristics of dry eye disease in Parkinson’s disease: a systematic review and meta-analysis

Nagino

Sung

Oyama

et al. 2022

Sci Rep

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We investigated and characterized the prevalence of dry eye disease (DED) in Parkinson’s disease (PD). PubMed and EMBASE databases were searched for relevant studies between January 1, 1979 and March 10, 2022. Quality was assessed using the Joanna Briggs Institute Critical Appraisal Checklist. Study-specific estimates were combined using the DerSimonian–Laird random-effects model. Prevalence of subjective DED symptoms in patients with PD and mean differences in blink rate, corneal thickness, tear film breakup time, and tear secretion volume on Schirmer test I were compared to those in controls. Of 383 studies, 13 (1519 patients with PD) and 12 were included in qualitative and quantitative syntheses, respectively. Meta-analysis revealed a 61.1% prevalence of subjective DED symptoms in PD and that, compared with controls, patients with PD had significantly lower blink rate, thinner corneal thickness, shorter tear film breakup time, and lower tear secretion volumes on Schirmer test I, without and with anesthesia.

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The Risks of Corneal Surface Damage in Aqueous-Deficient Dry Eye Disease: A 17-Year Population-Based Study in Taiwan

Cited by 17 publications

References 43 publications

Dry eye disease in patients with type II diabetes mellitus: A retrospective, population-based cohort study in Taiwan

Dry eye disease in patients with type II diabetes mellitus: A retrospective, population-based cohort study in Taiwan

Prevalence and associated factors for self-reported symptoms of dry eye among Thai school children during the COVID-19 outbreak

Prevalence and characteristics of dry eye disease in Parkinson’s disease: a systematic review and meta-analysis

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