The risks of monoamine oxidase inhibitors in the treatment of bronchial asthma

Mathov, E

doi:10.1016/0021-8707(63)90089-3

Cited by 12 publications

(2 citation statements)

References 8 publications

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“…Allergic complaints were not exacerbated in patients on monoamine oxidase inhibitors some of whom ate yeast extracts (Blackwell et al, 1965~). However, deterioration in nearly half of asthmatics receiving different inhibitors was reported by Mathov (1964).…”

Section: And Tyraminementioning

confidence: 99%

Histamine and Tyramine Content of Yeast Products

Blackwell¹,

Mabbitt²,

Marley³

1969

Journal of Food Science

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SUMMARY— Chromatographic estimations of tyramine and histamine in “Marmite” and four other yeast extracts showed a tyramine content from 0.1 to 1.6 mg/g and a histamine content of 0.2 to 2.8 mg/g. “Marmite” contained the largest amounts of both amines, but’ three samples of this extract showed a wide range in amine content. These variations in amine content of yeast extracts are discussed in terms of their manufacture. Pharmacological activity in one of the yeast extracts (“Marmite”) on the rat's blood pressure and on the intact bronchioles and isolated ileum of the guinea pig was due to the presence of tyramine and histamine. The clinical relevance of a high histamine content is discussed.

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Section: And Tyraminementioning

confidence: 99%

Histamine and Tyramine Content of Yeast Products

Blackwell¹,

Mabbitt²,

Marley³

1969

Journal of Food Science

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“…Endogenous histamine and serotonin may possibly be potentiated by MAO inhibitors. These drugs may occasionally evoke bronchial asthma (Mathov 1963, Holmberg & Sjoqvist 1964b). Patients with carcinoid syndrome are known to flush after tyramine and certain cheeses (Levine & Sjoerdsma 1963, Waldenstrom et al 1956), a reaction which might be enhanced after MAO inhibition.…”

Section: Summary Ofmechanisms Ofinteraction Between Mao Inhibitors and Other Substancesmentioning

confidence: 99%

Psychotropic Drugs (2) Interaction between Monoamine Oxidase (MAO) Inhibitors and other Substances

Sjöqvist

1965

Proceedings of the Royal Society of Medicine

104

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Monoamine oxidase inhibitors (MAOI) in clinical use have an irreversible action on MAO, and this persists until the enzyme has been resynthesized. The effects of small daily doses of MAOI are therefore cumulative. The biochemical effects of these drugs will involve several substrates of MAO, e.g. dopamine, tyramine, serotonin and, to a lesser extent, noradrenaline and adrenaline. MAO probably regulates the metabolism of catecholamines and serotonin in tissues, while catechol-O-methyltransferase is responsible for the metabolism of circulating noradrenaline and adrenaline. Certain pharmacological effects of MAOI are related to the accumulation of monoamines in various tissues that follows the decrease of intraneuronal deamination. Among these effects are reversal of the reserpine syndrome in animals and augmentation of the pharmacological action of monoamines. Other effects are unrelated to the inhibition of MAO, e.g. immediate desynchronization of EEG and initial pressor effects. MAOI may potentiate or change the action of several other drugs and even certain foods. The mechanisms involved are usually reasonably predictable from animal experiments. Substrates of MAO, e.g. dopamine and tyramine, evoke augmented and prolonged effects in patients treated with MAOI. This is partly due to an impaired metabolism of the circulating amines. In addition, inhibition of intestinal and hepatic MAO largely increases the absorption of tryamine from cheeses and other foods. Usually innocuous amounts of tyramine may therefore cause hypertensive reactions in patients treated with MAOI. Indirectly acting sympathomimetic amines, such as amphetamines, ephedrine and MAOI with amphetamine-like properties, can be potentiated, because they may release increased amounts of nor-adrenaline from sympathetic nerve endings after MAO inhibition. The effects of any amine, whether a substrate of MAO or not, may be enhanced by MAO inhibitors producing postganglionic block. This is due to ‘denervation’ supersensitivity of adrenergic receptors. Harmful pharmacological interaction is also possible between MAO inhibitors and agents which release (reserpine) or replete (amine precursors, e.g. L-DOPA in broad beans) monoamines centrally and peripherally. Drugs that sensitize adrenergic and tryptaminergic receptors to the action of monoamines, e.g. imipramine-like compounds, may be greatly potentiated by MAO inhibitors. The anti-hypertensive effects of thiazides and ganglion-blocking agents may be enhanced by MAOI. A few drugs are known to exert prolonged effects in occasional patients treated with MAOI, e.g. pethidine, phenothiazines and pentobarbital. MAOI may possibly decelerate the metabolism of these compounds by a nonspecific inhibition of liver microsomal enzymes. Finally, a great number of agents have been found empirically to evoke augmented effects after inhibition of MAO, e.g. insulin and anti-Parkinson drugs.

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Respiratory Disorders

Jefferson

Marshall

1981

Neuropsychiatric Features of Medical Disorders

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The risks of monoamine oxidase inhibitors in the treatment of bronchial asthma

Cited by 12 publications

References 8 publications

Histamine and Tyramine Content of Yeast Products

Histamine and Tyramine Content of Yeast Products

Psychotropic Drugs (2) Interaction between Monoamine Oxidase (MAO) Inhibitors and other Substances

Respiratory Disorders

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