The Risks of Sedation for Electroencephalograms: Data at Last

Freeman, John M.

doi:10.1542/peds.108.1.178

Cited by 11 publications

(1 citation statement)

References 5 publications

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“…Pharmacological agents, including barbiturates, chlorpromazine, triclofos and chloral hydrate, have all been employed to induce sleep, although most of them can impact the sleep macrostructure and/or affect the analysis of the recorded EEG data [15]. Furthermore, there is also the risk of slowly drifting into a deeper level of unconsciousness, eventually leading to upper airway obstruction and the loss of cough reflex; therefore, close observation and oxygen saturation monitoring are required [16].…”

Section: Ofmentioning

confidence: 99%

Efficacy of Liposomal Melatonin in sleep EEG in Childhood: A Double Blind Case Control Study

Bonuccelli

Santangelo

Castelli

et al. 2022

IJERPH

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Electroencephalography (EEG) is pivotal in the clinical assessment of epilepsy, and sleep is known to improve the diagnostic yield of its recording. Sleep-EEG recording is generally reached by either partial deprivation or by administration of sleep-inducing agents, although it is still not achieved in a considerable percentage of patients. We conducted a double-blind placebo-controlled study, involving a hundred patients between 1 and 6 years old, randomized into two groups: Group 1 received liposomal melatonin (melatosome) whereas Group 2 received a placebo. Sleep latency (SL), defined as the time span between the onset of a well-established posterior dominant rhythm, considered as a frequency of 3 to 4 Hz, increasing to 4–5 Hz by the age of 6 months, to 5–7 Hz by 12 months, and finally to 8 Hz by 3 years, and the first EEG sleep figures detected, were measured for each patient. A significant difference in SL was observed (10.8 ± 5 vs. 18.1 ± 13.4 min, p-value = 0.002). Within each group, no differences in sleep latency were detected between genders. Furthermore, no difference in EEG abnormality detection was observed between the two groups. Our study confirmed the efficacy and safety of melatonin administration in sleep induction. Nonetheless, liposomal melatonin presents a greater bioavailability, ensuring a faster effect and allowing lower dosages. Such results, never before reported in the literature, suggest that the routine employment of melatonin might improve clinical practice in neurophysiology, reducing unsuccessful recordings.

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Section: Ofmentioning

confidence: 99%