“…Although all authors applied the same algorithm, the results show a large variability. Among the independent validation studies there seem to be two clusters of results, one group with a low false prediction rate (<10%) but with insufficient sensitivity ( [8,11] and our study), and a second group with moderate sensitivity around 50% but with a high rate of false predictions [9,10,12,23]. Since the applied algorithm and the cut-off levels were the same in all investigations, S172…”