With the advent of Sixth Generation (6G) telecommunication systems already envisioned, increased effort is made to further develop current communication technologies, so they can be incorporated together with the novel ones, to deliver uninterrupted and satisfactory service for any application in every location on the ground, underwater, in the air, or in space. One such technology is Cognitive Radio (CR) which has received much attention due to its potential for increase of utilization, especially in the bands below 6 GHz. The main enabler for CR is spectrum sensing because it provides the opportunity for dynamic assessment of the radio environment to identify unused channels. This functionality has been the object of many research works for that very reason. In spite of this, the provision of accurate and fast spectrum characterization in time, frequency and space has proven to be a non-trivial task. This paper presents a detailed review of probabilistic spectrum sensing methods classified by the feature they extract from the received signal samples, to provide accurate detection of the primary user (PU) signal. The main design characteristics (such as probability of detection, robustness to noise and fading, signal/noise model assumptions, and computational complexity), strengths and weaknesses for each type are also summarized. Based on current concepts for 6G networks and applications, a framework for human-centric cognition-based wireless access is presented, which specifies the role of spectrum sensing-based CR in future networks.INDEX TERMS 6G, cognitive radio, feature detection, human-centric wireless access, Internet of Things, probabilistic spectrum sensing, wireless communications.