The Rodent Hippocampus Is Essential for Nonspatial Object Memory

Cohen, Sarah J.; Munchow, Alcira H.; Rios, Lisa M.; Zhang, Gongliang; Ásgeirsdóttir, Herborg N.; Stackman, Robert W.

doi:10.1016/j.cub.2013.07.002

Cited by 278 publications

(248 citation statements)

References 49 publications

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“…While some studies have shown normal object recognition memory in rodents with permanent hippocampal lesion [ (Duva et al 1997;Forwood et al 2005) but also see (Clark et al 2000)], a more recent study suggests that animals with hippocampal damages may recruit other extrahippocampal structures for the nonspatial recognition memory (Cohen et al 2013). In undamaged brains, neuronal activity in hippocampus is required for acquisition, consolidation, and retrieval of object recognition memory, which is blocked by intrahippocampal infusion of muscimol or the protein synthesis inhibitor anisomycin (Cohen et al 2013). Here, we demonstrate that intrahippocampal infusion of BDNF rescued object recognition memory deficits in AC1 KO mice.…”

Section: Discussionmentioning

confidence: 99%

“…S3). We next examined object recognition memory, which requires neuronal activity in the hippocampus (Clark et al 2000;Cohen et al 2013) and does not involve aversive stimulus. During training, WT and AC1 KO mice showed equal preference to object A and object B ( Fig.…”

Section: Ac1 Is Required For Hippocampal Ltp and Object Recognition Mmentioning

confidence: 99%

“…During testing (1 h after training), one of the old objects was replaced by a novel object. The number of sniffing/approaches was scored and expressed as "object preference" and "object discrimination index" as previously described (Wang et al 2004;Cohen et al 2013). …”

Section: Object Recognitionmentioning

confidence: 99%

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Voluntary running depreciates the requirement of Ca²⁺-stimulated cAMP signaling in synaptic potentiation and memory formation

et al. 2016

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Mental health and cognitive functions are influenced by both genetic and environmental factors. Although having active lifestyle with physical exercise improves learning and memory, how it interacts with the specific key molecular regulators of synaptic plasticity is largely unknown. Here, we examined the effects of voluntary running on long-term potentiation (LTP) and memory formation in mice lacking type 1 adenylyl cyclase (AC1), a neurospecific synaptic enzyme that contributes to Ca 2+ -stimulated cAMP production. Following 1 mo of voluntary running-wheel exercise, the impaired LTP and object recognition memory in AC1 knockout (KO) mice were significantly attenuated. Running up-regulated exon II mRNA level of BDNF (brain-derived neurotrophic factor), though it failed to increase exon I and IV mRNAs in the hippocampus of AC1 KO mice. Intrahippocampal infusion of recombinant BDNF was sufficient to rescue LTP and object recognition memory defects in AC1 KO mice. Therefore, voluntary running and exogenous BDNF application overcome the defective Ca 2+ -stimulated cAMP signaling. Our results also demonstrate that alteration in Ca 2+

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Section: Discussionmentioning

confidence: 99%

Section: Ac1 Is Required For Hippocampal Ltp and Object Recognition Mmentioning

confidence: 99%

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Voluntary running depreciates the requirement of Ca²⁺-stimulated cAMP signaling in synaptic potentiation and memory formation

et al. 2016

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“…We defined exploration as sniffing or touching the stimuli objects with the muzzle and/or forepaws. A discrimination index (DI = (Time exploring novel object À Time exploring familiar object)/Total object exploration time) was used as a measure of discrimination between familiar and novel objects (Aggleton, Albasser, Aggleton, Poirier, & Pearce, 2010;Aubele, Kaufman, Montalmant, & Kritzer, 2008;Langston & Wood, 2010;Cohen et al, 2008;Till et al, 2015). DI varies between À1 and +1.…”

Section: Behavioral Procedures and Data Analysismentioning

confidence: 99%

BDNF controls object recognition memory reconsolidation

Radiske

Rossato

Gonzalez

et al. 2017

Neurobiology of Learning and Memory

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a-amanitinMuscimol Novelty Retrieval a b s t r a c t Reconsolidation restabilizes memory after reactivation. Previously, we reported that the hippocampus is engaged in object recognition memory reconsolidation to allow incorporation of new information into the original engram. Here we show that BDNF is sufficient for this process, and that blockade of BDNF function in dorsal CA 1 impairs updating of the reactivated recognition memory trace.

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“…Analysis of phagocytic activity and cellsurface marker expression in microglia in the brain of 5xFAD mice also demonstrated that intake of iso-α-acids significantly ameliorated the decline in phagocytosis of Aβ in 5xFAD mice and enhanced CD36 expression. In addition, a novel object recognition test, a standard behavioral pharmacological evaluation [15], revealed that iso-α-acids prevent cognitive decline and memory impairment in 5xFAD mice.…”

Section: Introductionmentioning

confidence: 99%

Bitter Components in Beer Regulate Microglial Inflammation and Prevent Cognitive Decline

Ano¹,

Takashima²,

Nakayama³

2017

J Clin Cell Immunol

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Epidemiological studies suggest that moderate consumption of alcoholic beverages can reduce the risk of dementia. Recent work has demonstrated that intake of iso-α-acids, the bitter components in beer; prevent Alzheimer's disease pathology by regulating microglial function. In a transgenic mouse model of Alzheimer's disease, iso-α-acid intake led to a significant reduction of Aβ and inflammatory cytokines. In addition, iso-α-acids enhanced microglial phagocytosis of Aβ and induced microglia to an anti-inflammatory M2 type. These findings suggest that iso-α-acid consumption in daily life may be beneficial in preventing dementia.

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The Rodent Hippocampus Is Essential for Nonspatial Object Memory

Cited by 278 publications

References 49 publications

Voluntary running depreciates the requirement of Ca²⁺-stimulated cAMP signaling in synaptic potentiation and memory formation

Voluntary running depreciates the requirement of Ca²⁺-stimulated cAMP signaling in synaptic potentiation and memory formation

BDNF controls object recognition memory reconsolidation

Bitter Components in Beer Regulate Microglial Inflammation and Prevent Cognitive Decline

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The Rodent Hippocampus Is Essential for Nonspatial Object Memory

Cited by 278 publications

References 49 publications

Voluntary running depreciates the requirement of Ca2+-stimulated cAMP signaling in synaptic potentiation and memory formation

Voluntary running depreciates the requirement of Ca2+-stimulated cAMP signaling in synaptic potentiation and memory formation

BDNF controls object recognition memory reconsolidation

Bitter Components in Beer Regulate Microglial Inflammation and Prevent Cognitive Decline

Contact Info

Product

Resources

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Voluntary running depreciates the requirement of Ca²⁺-stimulated cAMP signaling in synaptic potentiation and memory formation

Voluntary running depreciates the requirement of Ca²⁺-stimulated cAMP signaling in synaptic potentiation and memory formation