The Role and Mechanism of the Up-Regulation of Fibrinolytic Activity in Painful Peripheral Nerve Injury

Nie, Yong; Cai, Guoping

doi:10.1007/s11064-008-9826-2

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…While several of these clinical conditions are characterized by acute or chronic pain [e.g., inflamed tissues (Lee et al, 2013; Alkhatib et al, 2014) or nerve injury (Sugimoto et al, 2008; Tsuda et al, 2008; Yong and Guoping, 2009; Tsuda et al, 2013)], the role of the ECM in the associated pain syndromes remains poorly understood. We have previously shown that versican, a large chondroitin sulfate proteoglycan ECM molecule that labels the non-peptidergic, isolectin B4 staining (IB4+) population of nociceptors helps to determine the function of these nociceptors (Bogen et al, 2005; Bogen et al, 2015).…”

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confidence: 99%

Extracellular matrix hyaluronan signals via its CD44 receptor in the increased responsiveness to mechanical stimulation

et al. 2016

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We propose that the extracellular matrix signals CD44, a hyaluronan receptor, to increase the responsiveness to mechanical stimulation. We report that intradermal injection of hyaluronidase induces mechanical hyperalgesia, that is inhibited by co-administration of a CD44 receptor antagonist, A5G27. The intradermal injection of low (LMWH) but not high (HMWH) molecular weight hyaluronan also induces mechanical hyperalgesia, an effect that was attenuated by the pretreatment with HMWH or A5G27. Pretreatment with HMWH also attenuated the hyperalgesia induced by hyaluronidase. Similarly, intradermal injection of A6, a CD44 receptor agonist, produced hyperalgesia that was inhibited by HMWH and A5G27. Inhibitors of protein kinase A and Src, but not protein kinase C, significantly attenuated the hyperalgesia induced by both A6 and LMWH. Finally, to determine if CD44 receptor signaling is involved in a preclinical model of inflammatory pain, we evaluated the effect of A5G27 and HMWH on the mechanical hyperalgesia associated with the inflammation induced by carrageenan. Both A5G27 and HMWH attenuated carrageenan-induced mechanical hyperalgesia. Thus, while LMWH acts at its cognate receptor, CD44, to induce mechanical hyperalgesia, HMWH acts at the same receptor as an antagonist. That the local administration of HMWH or A5G27 inhibits carrageenan-induced hyperalgesia supports the suggestion that carrageenan produces changes in the extracellular matrix that contributes to inflammatory pain. These studies define a clinically relevant role for signaling by the hyaluronan receptor, CD44, in increased responsiveness to mechanical stimulation.

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confidence: 99%

Extracellular matrix hyaluronan signals via its CD44 receptor in the increased responsiveness to mechanical stimulation

et al. 2016

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“…The implementation of these components into a nerve conduit delivery system will enable a degree of control over the length and processes of the Wallerian degeneration phase [14, 24, 63]. Wallerian degeneration is a term describing the rapid breakdown of axons and myelin sheaths after injury to neural tissues (Figure 3) [64]. Although it is a process triggered for the creation of a microenvironment supportive for nerve regeneration, it additionally initiates the onset of inflammation and intensification of pain [9, 24, 45, 65–68].…”

Section: Requirements For Optimal Peripheral Nerve Regenerationmentioning

confidence: 99%

A Review of Bioactive Release from Nerve Conduits as a Neurotherapeutic Strategy for Neuronal Growth in Peripheral Nerve Injury

Ramburrun

Kumar

Choonara

et al. 2014

BioMed Research International

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Peripheral nerve regeneration strategies employ the use of polymeric engineered nerve conduits encompassed with components of a delivery system. This allows for the controlled and sustained release of neurotrophic growth factors for the enhancement of the innate regenerative capacity of the injured nerves. This review article focuses on the delivery of neurotrophic factors (NTFs) and the importance of the parameters that control release kinetics in the delivery of optimal quantities of NTFs for improved therapeutic effect and prevention of dose dumping. Studies utilizing various controlled-release strategies, in attempt to obtain ideal release kinetics, have been reviewed in this paper. Release strategies discussed include affinity-based models, crosslinking techniques, and layer-by-layer technologies. Currently available synthetic hollow nerve conduits, an alternative to the nerve autografts, have proven to be successful in the bridging and regeneration of primarily the short transected nerve gaps in several patient cases. However, current research emphasizes on the development of more advanced nerve conduits able to simulate the effectiveness of the autograft which includes, in particular, the ability to deliver growth factors.

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Tissue plasminogen activator and neuropathy open the blood-nerve barrier with upregulation of microRNA-155-5p in male rats

Reinhold

Yang

Chen

et al. 2019

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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The Role and Mechanism of the Up-Regulation of Fibrinolytic Activity in Painful Peripheral Nerve Injury

Cited by 3 publications

References 21 publications

Extracellular matrix hyaluronan signals via its CD44 receptor in the increased responsiveness to mechanical stimulation

Extracellular matrix hyaluronan signals via its CD44 receptor in the increased responsiveness to mechanical stimulation

A Review of Bioactive Release from Nerve Conduits as a Neurotherapeutic Strategy for Neuronal Growth in Peripheral Nerve Injury

Tissue plasminogen activator and neuropathy open the blood-nerve barrier with upregulation of microRNA-155-5p in male rats

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