The role and mechanism of long non-coding RNA H19 in stem cell osteogenic differentiation

Abstract

Background In recent years, H19, as one of the most well-known long non-coding RNA, has been reported to play important roles in many biological and physiological processes. H19 has been identified to regulate the osteogenic differentiation of various stem cells in many studies. However, the detailed role and regulation mechanism of H19 was not consistent in the reported studies. Main body of the manuscript In this review article we summarized the effect and mechanism of lncRNA H19 on osteogenic differentiation of various stem cells reported in the published literatures. The role and mechanism of H19, H19 expression changes, effect of H19 on cell proliferation in osteogenic differentiation were respectively reviewed. Conclusions An increasing number of studies have provided evidence that H19 play its role in the regulation of stem cell osteogenic differentiation by different mechanisms. Most of the studies favored the positive regulatory effect of H19 through lncRNA-miRNA pathway. The function and underlying mechanisms by which H19 contributes to osteogenic differentiation require further investigation.

Hair follicle mesenchymal stem cell exosomal lncRNA H19 inhibited NLRP3 pyroptosis to promote diabetic mouse skin wound healing

“…lncRNA H19 is a highly conserved gene that has gained extensive research attention in the fields of cancer and cardiovascular disease [ 21 , 22 ]. Furthermore, it has recently been linked to the skin and smooth muscles, stem cell differentiation and embryonic development [ 23 , 24 ]. lncRNA H19 has been found to be expressed in abundance in embryonic tissues, demonstrating its prospective role in shaping the growth of embryonic cells [ 25 ].…”

Differential Expression of Non-Coding RNAs in Stem Cell Development and Therapeutics of Bone Disorders

“…However, some lncRNAs participate in the pathological process of OP by regulating mRNA expression or osteoclast differentiation [ 32 ]. In the Notch signaling pathway, the regulatory effect of H19 (lncRNA) on the expression of delta-like ligand-1 (DLL1), delta-like ligand-3 (DLL3), delta-like ligand-4 (DLL4), Jagged-1 (JAG1) and Jagged-2 (JAG2), by regulating the expression of miRNAs (miR-17, miR-107, miR-27b, miR-106b, and miR-125a) downstream, enhanced the expression of bone morphogenetic protein-9 (BMP 9) and induced MSCs osteogenic differentiation [ 33 ].…”

The role of long noncoding RNA H19 in gynecological pathologies: Insights into gene regulation and immune modulation (Review)

“…This pattern implies the pivotal role of lncRNA H19 in embryogenesis and fetal growth (27,28). Postnatal expression of lncRNA H19 diminishes significantly but maintains a residual level in select tissues, including breast, uterus, myocardium, skeletal muscle and the adrenal gland (29)(30)(31)(32)(33)(34). During tissue regeneration or tumorigenesis, lncRNA H19 function reactivates, participating in damage regulation and repair, or acting as either a tumor suppressor gene or an oncogene (35,36).…”