The role and participation of immune cells in the endometrial tumor microenvironment

Dey, Debasish Kumar; Krause, Danielle; Rai, Rajani; Choudhary, Swati; Dockery, Lauren E.; Chandra, Vishal

doi:10.1016/j.pharmthera.2023.108526

Cited by 6 publications

(2 citation statements)

References 168 publications

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“…The presence of endometriosis did not affect overall survival in those women [42]. It is important to establish the role of immune cells and the tumor microenvironment, in which inflammatory cytokines have a significant role, in the development and progression of the malignant transformation of endometriosis in order to explore innovative approaches for identifying effective drugs [43].…”

Section: Malignant Transformations In Endometriosismentioning

confidence: 99%

Endometriosis and the Role of Pro-Inflammatory and Anti-Inflammatory Cytokines in Pathophysiology: A Narrative Review of the Literature

Oală,

Mitranovici,

Chiorean

et al. 2024

Diagnostics

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Endometriosis is a chronic inflammatory disease, which explains the pain that such patients report. Currently, we are faced with ineffective, non-invasive diagnostic methods and treatments that come with multiple side effects and high recurrence rates for both the disease and pain. These are the reasons why we are exploring the possibility of the involvement of pro-inflammatory and anti-inflammatory molecules in the process of the appearance of endometriosis. Cytokines play an important role in the progression of endometriosis, influencing cell proliferation and differentiation. Pro-inflammatory molecules are found in intrafollicular fluid. They have an impact on the number of mature and optimal-quality oocytes. Endometriosis affects fertility, and the involvement of endometriosis in embryo transfer during in vitro fertilization (IVF) is being investigated in several studies. Furthermore, the reciprocal influence between anti-inflammatory and pro-inflammatory cytokines and their role in the pathogenesis of endometriosis has been assessed. Today, we can affirm that pro-inflammatory and anti-inflammatory cytokines play roles in survival, growth, differentiation, invasion, angiogenesis, and immune escape, which provides a perspective for approaching future clinical implications and can be used as biomarkers or therapy.

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Section: Malignant Transformations In Endometriosismentioning

confidence: 99%

Endometriosis and the Role of Pro-Inflammatory and Anti-Inflammatory Cytokines in Pathophysiology: A Narrative Review of the Literature

Oală,

Mitranovici,

Chiorean

et al. 2024

Diagnostics

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“…The ECM is a key constitutive part of the TME, consisting principally of reactive tissue components including glycoproteins, collagens, and many enzymes that have an impact on cell adhesion, proliferation, and communication. These substances can change their physical properties, composition, and the environment in which they live to affect tumor cell migration, while the concentration of ECM also determines the ratio of tumor cell migration from one region to another (72)(73)(74)(75)(76). Additionally, nonmalignant cells in the TME are prominently separated into two primary groups, immune cells and mesenchymal stromal cells, which stimulate and promote uncontrolled cell proliferation to affect all stages of carcinogenesis (77)(78)(79).…”

Section: The Overview Of Tamsmentioning

confidence: 99%

Exosome-mediated communication between gastric cancer cells and macrophages: implications for tumor microenvironment

Qiu,

Lu,

et al. 2024

Front. Immunol.

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Gastric cancer (GC) is a malignant neoplasm originating from the epithelial cells of the gastric mucosa. The pathogenesis of GC is intricately linked to the tumor microenvironment within which the cancer cells reside. Tumor-associated macrophages (TAMs) primarily differentiate from peripheral blood monocytes and can be broadly categorized into M1 and M2 subtypes. M2-type TAMs have been shown to promote tumor growth, tissue remodeling, and angiogenesis. Furthermore, they can actively suppress acquired immunity, leading to a poorer prognosis and reduced tolerance to chemotherapy. Exosomes, which contain a myriad of biologically active molecules including lipids, proteins, mRNA, and noncoding RNAs, have emerged as key mediators of communication between tumor cells and TAMs. The exchange of these molecules via exosomes can markedly influence the tumor microenvironment and consequently impact tumor progression. Recent studies have elucidated a correlation between TAMs and various clinicopathological parameters of GC, such as tumor size, differentiation, infiltration depth, lymph node metastasis, and TNM staging, highlighting the pivotal role of TAMs in GC development and metastasis. In this review, we aim to comprehensively examine the bidirectional communication between GC cells and TAMs, the implications of alterations in the tumor microenvironment on immune escape, invasion, and metastasis in GC, targeted therapeutic approaches for GC, and the efficacy of potential GC drug resistance strategies.

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Identification of genetic and immune mechanisms linking preeclampsia and endometrial cancer: a prognostic model for survival and treatment response

Teng,

Fang,

Wang

et al. 2024

Discov Onc

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The role and participation of immune cells in the endometrial tumor microenvironment

Cited by 6 publications

References 168 publications

Endometriosis and the Role of Pro-Inflammatory and Anti-Inflammatory Cytokines in Pathophysiology: A Narrative Review of the Literature

Endometriosis and the Role of Pro-Inflammatory and Anti-Inflammatory Cytokines in Pathophysiology: A Narrative Review of the Literature

Exosome-mediated communication between gastric cancer cells and macrophages: implications for tumor microenvironment

Identification of genetic and immune mechanisms linking preeclampsia and endometrial cancer: a prognostic model for survival and treatment response

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