The literature argues for using care pathways to manage better services for intervening with young people who use or misuse substances and recommends their contents. We conclude that care pathways should be based on strategic models of care; however, there remain areas of uncertainty, including those about the balance of services that should be delivered, adoption of prevention programmes, and development of audit tools to monitor the impacts and effectiveness of care pathways. This review provides our recommended list of contents for models of care on which we recommend that associated care pathways should be based.