The Role of 17β-Estrogen in Candida albicans Adhesion on Human Vaginal Epithelial Cells via FAK Phosphorylation

Luan, Ting; Liu, Xia; Mao, Pengyuan; Wang, Xinyan; Cheng, Rui; Yan, Lei; Wang, Yiquan; Fan, Chong; Li, Ping; Zeng, Xin

doi:10.1007/s11046-020-00440-1

Cited by 11 publications

(5 citation statements)

References 32 publications

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“…The occurrence of VVC is related to the crucial virulence factors of C. albicans, such as secreted aspartyl proteinases (Sap), lipases (Lip), phospholipases (PL), candidalysin, morphological transition, and biofilm formation ( Richardson et al, 2018 ; Willems et al, 2020 ). On the other hand, the virulence of C. albicans also depends on host immune status, especially the immune defense function of vaginal epithelial cells ( Luan et al, 2020 ). C. albicans interacts with epithelial cells through adhesins on the cell wall ( Martin et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Berberine Inhibits the Adhesion of Candida albicans to Vaginal Epithelial Cells

et al. 2022

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Vulvovaginal candidiasis (VVC) is an inflammatory disease of the vagina mainly caused by Candida albicans (C. albicans), which affects around three-quarters of all women during their reproductive age. Although some antifungal drugs such as azoles have been applied clinically for many years, their therapeutic value is very limited due to the emergence of drug-resistant strains. Previous studies have shown that the adhesion of C. albicans to vaginal epithelial cells is essential for the pathogenesis of VVC. Therefore, preventing the adhesion of C. albicans to vaginal epithelial cells may be one of the most effective strategies for the treatment of VVC. Berberine (BBR) is a biologically active herbal alkaloid that was used to treat VVC. However, so far, its mechanism has remained unclear. This study shows BBR significantly inhibits the adhesion of C. albicans to vaginal epithelial cells by reducing the expressions of ICAM-1, mucin1, and mucin4 in vaginal epithelial cells, which play the most important role in modulating the adhesion of C. albicans to host cells, and balancing IL-2 and IL-4 expressions, which play a key effect on regulating the inflammatory response caused by C. albicans infection. Hence, our findings demonstrate that BBR may be a potential therapeutic agent for VVC by interfering with the adhesion of C. albicans to vaginal epithelial cells and represents a new pathway for developing antifungal therapies agents from natural herbs.

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Section: Introductionmentioning

confidence: 99%

Berberine Inhibits the Adhesion of Candida albicans to Vaginal Epithelial Cells

et al. 2022

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“…Some studies have reported that although there is no significant difference in the prevalence of vulvovaginal candidiasis between women who are taking oral contraceptives and those who are not, the detection rate of vaginal Candida albicans is positively correlated with the content of estrogen in contraceptives (16). These results demonstrate that estrogen can enhance the adhesion and invasiveness of Candida albicans (15,17). Estrogen exerts anti-inflammatory effects, including the inhibition of pro-inflammatory gene transcription and cytokine production, as well as in several disease models such as autoimmunity, atherosclerosis, arthritis, inflammatory intestinal diseases, asthma, and influenza (18,19).…”

Section: Discussionmentioning

confidence: 92%

The role of estrogen in circular RNA and metabonomics in a Neisseria gonorrhoeae infection model

Cai¹,

Jin²,

Hu³

et al. 2022

Ann Transl Med

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Background: Previous study shows that estrogen exerts both immunosuppressive and immunostimulative effects.Methods: In this study, estrogen was added to a Neisseria gonorrhoeae infection model, and transcriptome sequencing and metabolomics studies were performed to clarify the changes in circular RNA (circRNA) and metabolic pathways regulated by the addition of estrogen. Results:The results showed that following the addition of estrogen to the gonococcal infection model, the expression of circRNAs was up-regulated and the expression of circRNAs was down-regulated. In the metabolic group, it was found that after the addition of estrogen, the expression of nine metabolites was down-regulated and 61 metabolites were up-regulated. Furthermore, through network interaction analysis of differentially-expressed circRNAs and differentially-expressed metabolites, we found that the top 10 significantly related metabolites and circRNA were 2-Epoxybutane/novel_circ_0024520;

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“…The pregnant mice were then randomly divided into two groups: the VVC group ( n = 24) and the control group ( n = 23). The pregnant female mice received either C. albicans in LB medium [20 μl; 2% (v/v); about 2 × 10 7 CFU] ( Conti et al, 2014 ; Luan et al, 2020 ) or the same volume of phosphate-buffered saline (PBS) control via intravaginal inoculation at E4.5 in the VVC group and the control group, respectively. Care was taken to minimize vaginal leakage of the administered bolus.…”

Section: Methodsmentioning

confidence: 99%

Vaginal Exposure to Candida albicans During Early Gestation Results in Adverse Pregnancy Outcomes via Inhibiting Placental Development

et al. 2022

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Vulvovaginal candidiasis (VVC) is considered the second most common cause of vaginitis after bacterial vaginosis and the most common lower genital tract infection during pregnancy. Candida albicans (C. albicans), an opportunistic pathogen, is the major species causing VVC. Recently, increasing researches have shown that lower reproductive tract infection during pregnancy can lead to various adverse pregnancy outcomes. However, the underlying mechanisms are not fully understood. Hence, we successfully established a mouse model of vaginal C. albicans infection and characterized the adverse pregnancy outcomes. C. albicans infection strikingly increased abortion rate and decreased litter size. Further analysis of placental development demonstrated that placental structure was abnormal, including that the area of spongiotrophoblast (Spo) and labyrinth (Lab) was reduced, and the formation of placental vessel was decreased in Lab zone. Accordingly, the expression of marker genes during placental development was downregulated. Collectively, the above findings revealed that vaginal C. albicans infection during pregnancy can inhibit placental development and ultimately lead to adverse pregnancy outcomes. This study enhances our comprehension of the effect of VVC on pregnancy, and placental dysplasia as a feasible orientation to explore VVC during pregnancy.

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The Role of 17β-Estrogen in Candida albicans Adhesion on Human Vaginal Epithelial Cells via FAK Phosphorylation

Cited by 11 publications

References 32 publications

Berberine Inhibits the Adhesion of Candida albicans to Vaginal Epithelial Cells

Berberine Inhibits the Adhesion of Candida albicans to Vaginal Epithelial Cells

The role of estrogen in circular RNA and metabonomics in a Neisseria gonorrhoeae infection model

Vaginal Exposure to Candida albicans During Early Gestation Results in Adverse Pregnancy Outcomes via Inhibiting Placental Development

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