The Role of 18F-FDG-PET/CT Scan in the Management of Multiple Myeloma

Haghighat, Shirin

doi:10.31557/apjcc.2020.5.2.119-123

Cited by 2 publications

(3 citation statements)

References 42 publications

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“…Multiple myeloma is a plasma cell dyscrasia characterized by multi-organ involvement including osteoclastic activation leading to osteolytic bony lesions observed in 80% of MM patients. 10 It is one of the most frequent presentations therefore prompt evaluation by imaging techniques is the corner stone of diagnosis of bone involvement in MM patients. In terms of diagnosis, skeletal survey is less sensitive than PET/CT although it was used to be the gold standard modality for evaluation of bony lesions.…”

Section: Discussionmentioning

confidence: 99%

Radiological outcome of bone disease in multiple myeloma patients pre- and post therapy

Aljohani

Saib²,

Syed³

et al. 2022

SMJ

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Objectives: To find any correlation between the clinical response as per International Working Myeloma Group (IWMG) response criteria and the radiological response at the end of treatment.Methods: A retrospective cohort study was conducted, total of 39 patients whom diagnosed with multiple myeloma (MM) between January 2010 and December 2018 and fulfilled the study criteria were included. Results:The high sensitivity and specificity of positron emission tomography/computed tomography (PET/ CT) in detecting osteolytic myeloma lesions in the bones was strongly emphasized in our study. Follow up PET/CT, we found that while 17 patients showed complete remission in PET/CT, and 14 of these of patients demonstrated a complete clinical response at end of therapy assessment. Conclusion:Although we did not find a statistically significant correlation between the response versus metabolic activity and the number of bone/bone marrow lesions, however, our study was limited by the absence of clear criteria for defining disease response in PET/CT in MM patients. Further prospective analysis would be needed to establish a defined criterion.

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Section: Discussionmentioning

confidence: 99%

Radiological outcome of bone disease in multiple myeloma patients pre- and post therapy

Aljohani

Saib²,

Syed³

et al. 2022

SMJ

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show abstract

“…The most significant advantage of 18 F-FDG PET/CT is its ability to accurately assess the severity of the disease and to distinguish between active metabolic lesions and inactive lesions [ 39 – 41 ]. PET/CT reveals multiple osteolytic lesions throughout the skeleton ( Figure 3 ) (skull, ribs, upper limbs, femurs, pelvis and spine), with a short image acquisition time with 3-D tomographs, important in patients with fractures or bone pain [ 42 , 43 ].…”

Section: Positron Emission Tomography With Computed Tomography 18f-de...mentioning

confidence: 99%

“…A systematic review of 18 studies comparing 18 F-FDG PET/CT with WBXR, or MRI, confirmed that MRI is the gold standard technique for assessing diffuse involvement of the bone marrow, while 18 F-FDG PET/CT is more sensitive than WBXR for bone damage detection [ 39 , 50 ].…”

Section: Positron Emission Tomography With Computed Tomography 18f-de...mentioning

confidence: 99%

Modern imaging techniques in the monitoring of patients with multiple myeloma

Pop

Tomoaia

Pârvu

2022

Medicine and Pharmacy Reports

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Bone disease for many patients is a serious problem, often causing pathological bone fractures; a spinal collapse, in conclusion, is a disease that affects the quality of life. It is the most frequent feature of multiple myeloma (MM), and it is used to put a diagnostic and the need to start treatment. Because of these complications, imaging plays a vital role in the diagnosis and workup of myeloma patients. For many years, the conventional radiography has long been considered the gold standard for detecting bone lesions. The main reasons are the wide availability, the low cost, the relatively low radiation dose, and the ability of this imaging method to cover the entire bone system. Because of its incapacity to evaluate the response therapy, more sophisticated techniques such as whole-body low-dose computed tomography (WBLDCT), whole-body magnetic resonance imaging, and 18F-fluorodeoxyglucose–positron emission tomography/computed tomography (PET/CT). In this review, some of the advantages, indications of use, and applications of the three techniques in managing patients with MM will be discussed. The European Myeloma Network guidelines have recommended WBLDCT as the imaging modality of choice for the initial assessment of MM-related lytic bone lesions. Magnetic resonance imaging is the gold-standard imaging modality for the detection of bone marrow involvement. One of the modern imaging methods and PET/CT can provide valuable prognostic data and is the preferred technique for assessing response to therapy.

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The Role of 18F-FDG-PET/CT Scan in the Management of Multiple Myeloma

Cited by 2 publications

References 42 publications

Radiological outcome of bone disease in multiple myeloma patients pre- and post therapy

Radiological outcome of bone disease in multiple myeloma patients pre- and post therapy

Modern imaging techniques in the monitoring of patients with multiple myeloma

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