The frontoethmoidal region is an anatomical complex of the middle and upper mass of the face, placed at the mouth of numerous regions, such as the upper jaw, cranium, orbital and nasal region. The multitude of anatomical elements in a small space with a specific function makes this region very demanding for the diagnosis and treatment of pathological entities. Extensive tumors of this region are a special diagnostic and therapeutic problem. Surgical treatment includes rhinotomy, sinusotomy, orbitotomy, frontectomy, and other types of operations. In the case of skull base extension, the situation becomes more complicated, which leads to the need for the cooperation of several specialists and modification of the surgical technique. A special problem in this region is adequate reconstruction. More specialists perform surgical procedures in these regions. These include maxillofacial surgeons, ENT (ear, nose, and throat) specialists, neurosurgeons, oncological surgeons, and ophthalmologists.