The Role of 3D Printing in the Fight Against Covid-19 Outbreak

Radfar, Payar; Bazaz, Sajad Razavi; Mirakhorli, Fateme; Warkiani, Majid Ebrahimi

doi:10.2217/3dp-2020-0028

Cited by 22 publications

(13 citation statements)

References 51 publications

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“…Not only was 3D printing used to crucially help with this shortfall, it demonstrated, in real time, how fast translation can be when problem and outcome focused. (Radfar et al, 2021).…”

Section: Rise Of the Prosumermentioning

confidence: 99%

How 3D Printing Is Reshaping Translational Research

Sigston

2021

Front. Bioeng. Biotechnol.

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“Translational Research” has traditionally been defined as taking basic scientific findings and developing new diagnostic tools, drugs, devices and treatment options for patients, that are translated into practice, reach the people and populations for whom they are intended and are implemented correctly. The implication is of a unidirectional flow from “the bench to bedside”. The rapidly emergent field of additive manufacturing (3D printing) is contributing to a major shift in translational medical research. This includes the concept of bidirectional or reverse translation, early collaboration between clinicians, bio-engineers and basic scientists, and an increasingly entrepreneurial mindset. This coincides with, and is strongly complemented by, the rise of systems biology. The rapid pace at which this type of translational research can occur brings a variety of potential pitfalls and ethical concerns. Regulation surrounding implantable medical devices is struggling to keep up. 3D printing has opened the way for personalization which can make clinical outcomes hard to assess and risks putting the individual before the community. In some instances, novelty and hype has led to loss of transparency of outcomes with dire consequence. Collaboration with commercial partners has potential for conflict of interest. Nevertheless, 3D printing has dramatically changed the landscape of translational research. With early recognition and management of the potential risks, the benefits of reshaping the approach to translational research are enormous. This impact will extend into many other areas of biomedical research, re-establishing that science is more than a body of research. It is a way of thinking.

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“…Not only was 3D printing used to crucially help with this shortfall, it demonstrated, in real time, how fast translation can be when problem and outcome focused. (Radfar et al, 2021).…”

Section: Rise Of the Prosumermentioning

confidence: 99%

How 3D Printing Is Reshaping Translational Research

Sigston

2021

Front. Bioeng. Biotechnol.

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“…Additive manufacturing (AM) is transforming medical supplies by allowing personalisation and onsite fabrication enhancing resilience against supply chain disruption [ 61 , 62 , 63 , 64 ]. This subsequently results in rapid development and deployment of potential solutions which is critical when it comes to pandemic preparedness [ 65 , 66 , 67 ]. Nevertheless, achieving this requires the development of antimicrobial materials [ 68 , 69 , 70 ] and processes that can be additively manufactured without the requirement for complex pre/post-processing as demonstrated in this study.…”

Section: Introductionmentioning

confidence: 99%

3D Printed Cobalt-Chromium-Molybdenum Porous Superalloy with Superior Antiviral Activity

Arjunan

Robinson

Baroutaji

et al. 2021

IJMS

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COVID-19 pandemic and associated supply-chain disruptions emphasise the requirement for antimicrobial materials for on-demand manufacturing. Besides aerosol transmission, SARS-CoV-2 is also propagated through contact with virus-contaminated surfaces. As such, the development of effective biofunctional materials that can inactivate SARS-CoV-2 is critical for pandemic preparedness. Such materials will enable the rational development of antiviral devices with prolonged serviceability, reducing the environmental burden of disposable alternatives. This research reveals the novel use of Laser Powder Bed Fusion (LPBF) to 3D print porous Cobalt-Chromium-Molybdenum (Co-Cr-Mo) superalloy with potent antiviral activity (100% viral inactivation in 30 min). The porous material was rationally conceived using a multi-objective surrogate model featuring track thickness (tt) and pore diameter (ϕd) as responses. The regression analysis found the most significant parameters for Co-Cr-Mo track formation to be the interaction effects of scanning rate (Vs) and laser power (Pl) in the order PlVs>Vs>Pl. Contrastively, the pore diameter was found to be primarily driven by the hatch spacing (Sh). The study is the first to demonstrate the superior antiviral properties of 3D printed Co-Cr-Mo superalloy against an enveloped virus used as biosafe viral model of SARS-CoV-2. The material significantly outperforms the viral inactivation time of other broadly used antiviral metals such as copper and silver, as the material’s viral inactivation time was from 5 h to 30 min. As such, the study goes beyond the current state-of-the-art in antiviral alloys to provide extra protection to combat the SARS-CoV-2 viral spread. The evolving nature of the COVID-19 pandemic brings new and unpredictable challenges where on-demand 3D printing of antiviral materials can achieve rapid solutions while reducing the environmental impact of disposable devices.

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“…Additive manufacturing (AM) is transforming medical supplies by allowing personalisation and onsite fabrication enhancing resilience against supply chain disruption [20][21][22]. This subsequently results in rapid development and deployment of potential solutions which is critical when it comes to pandemic preparedness [23][24][25]. Nevertheless, achieving this requires the development of antimicrobial materials [26][27][28] and processes that can be additively manufactured without the requirement for complex pre/post-processing as demonstrated in this study.…”

Section: Introductionmentioning

confidence: 99%

3D printed cobalt-chromium-molybdenum porous superalloy with superior antiviral activity

Arjunan

Robinson

Baroutaji

et al. 2021

Preprint

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COVID-19 pandemic and associated supply-chain disruptions emphasise the requirement for antimicrobial materials for on-demand manufacturing. Besides aerosol transmission, SARS-CoV-2 is also propagated through contact with virus-contaminated surfaces. As such, the development of effective biofunctional materials that can inactivate SARS-CoV-2 is critical for pandemic preparedness. Such materials will enable the rational development of antiviral devices with prolonged serviceability, reducing the environmental burden of disposable alternatives. This research reveals the novel use of Laser Powder Bed Fusion (LPBF) to 3D print porous Cobalt-Chromium-Molybdenum (Co-Cr-Mo) superalloy with potent antiviral activity (100% viral inactivation in 30 mins). The porous material was rationally conceived using a multi-objective surrogate model featuring track thickness (tt) and pore diameter (ϕd) as responses. The regression analysis found the most significant parameters for Co-Cr-Mo track formation to be the interaction effects of scanning rate (Vs) and laser power (Pl) in the order PlVs>Vs>Pl. Contrastively, the pore diameter was found to be primarily driven by the hatch spacing (Sh). The study is the first to demonstrate the superior antiviral properties of 3D printed Co-Cr-Mo superalloy against an enveloped virus used as biosafe viral model of SARS CoV 2. The material significantly outperforms the viral inactivation time of other broadly used antiviral metals such as copper and silver from 5 hours to 30 minutes. As such, the study goes beyond the current state-of-the-art in antiviral alloys to provide extra protection to combat the SARS-COV-2 viral spread. The evolving nature of the COVID-19 pandemic brings new and unpredictable challenges where on-demand 3D printing of antiviral materials can achieve rapid solutions while reducing the environmental impact of disposable devices.

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The Role of 3D Printing in the Fight Against Covid-19 Outbreak

Cited by 22 publications

References 51 publications

How 3D Printing Is Reshaping Translational Research

How 3D Printing Is Reshaping Translational Research

3D Printed Cobalt-Chromium-Molybdenum Porous Superalloy with Superior Antiviral Activity

3D printed cobalt-chromium-molybdenum porous superalloy with superior antiviral activity

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