The role of 5-HT1A receptors in fish oil-mediated increased BDNF expression in the rat hippocampus and cortex: A possible antidepressant mechanism

Vines, Aparecida; Delattre, A; Lima, Marcelo M.S.; Rodrigues, Laís S.; Suchecki, Deborah; Machado, Ricardo Borges; Tufik, Sérgio; Pereira, Sofia Isabel Ribeiro; Zanata, Sı́lvio M.; Ferraz, Anete Curte

doi:10.1016/j.neuropharm.2011.06.017

Cited by 105 publications

(69 citation statements)

References 59 publications

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“…For example, rats fed DHA-adequate diets from gestation to 18 weeks old had elevated BDNF protein in the hippocampus and hypothalamus ( 80 ), and those fed an ␣ -linolenic acid suffi cient diet from weaning to 18 weeks old had elevated BDNF protein expression in the frontal cortex ( 81 ) compared with animals on defi cient diets. In addition, fi sh oil supplementation during gestation and lactation increased hippocampal and cortical BDNF protein levels in 21-dayold and 90-day-old rats ( 49 ). Our data are in line with these reports but suggest that the effects of dietary DHA during development on brain BDNF protein levels are likely dependent on the timing of DHA supplementation in a brain region-specifi c manner.…”

Section: Downloaded Fromsupporting

confidence: 90%

“…Brain serotonin content is well known to be dependent on plasma tryptophan concentration ( 47 ), and the circulating serotonin level may also be an indicator of brain serotonin concentration ( 48 ). In a recent study, rats supplemented with high-DHA fi sh oil from gestation to adulthood exhibited decreased immobility in the FST and had increased levels of serotonin in the hippocampus and cortex, effects that were inhibited by acute treatment with a 5-HT 1A serotonin receptor antagonist ( 49 ). This suggests that optimal DHA status may enhance serotonergic neurotransmission, thereby improving depressive-like behaviors.…”

Section: Discussionmentioning

confidence: 99%

“…Both Naliwaiko et al ( 84 ) and Vines et al ( 49 ) reported that fi sh oil supplementation throughout gestation, lactation, and after weaning resulted in male offspring that exhibited reduced immobility in the FST compared with controls when tested as adults. In addition, studies by Ferraz et al ( 85 ) and DeMar et al ( 86 ) indicated that feeding male rats diets supplemented with fi sh oil or ␣ -linolenic acid, respectively, after weaning (P21) into adulthood for 6 months decreased data, only trace levels of EPA are found in the brain where upon entry it is rapidly ␤ -oxidized and metabolized ( 97,98 ).…”

Section: Downloaded Frommentioning

confidence: 99%

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Dietary DHA during development affects depression-like behaviors and biomarkers that emerge after puberty in adolescent rats

Weiser¹,

Wynalda²,

Salem³

et al. 2015

Journal of Lipid Research

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Section: Downloaded Fromsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Downloaded Frommentioning

confidence: 99%

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Dietary DHA during development affects depression-like behaviors and biomarkers that emerge after puberty in adolescent rats

Weiser¹,

Wynalda²,

Salem³

et al. 2015

Journal of Lipid Research

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“…Earlier studies have described the positive influence of DHA on BDNF expression in vitro in induced pluripotent stem cells [89], and in the CNS [90][91][92]. Similarly to IL-6, the lowest concentrations of EPA resulted in an increase in BDNF levels that disappeared at higher concentrations.…”

Section: Discussionmentioning

confidence: 93%

Omega-3 Fatty Acids Enhance Phagocytosis of Alzheimer's Disease-Related Amyloid-β42 by Human Microglia and Decrease Inflammatory Markers

Hjorth

Zhu

Toro

et al. 2013

JAD

203

154

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Abstract. The use of supplements with omega-3 (ω3) fatty acids (FAs) such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) is widespread due to proposed beneficial effects on the nervous and cardiovascular systems. Many effects of ω3 FAs are believed to be caused by down-regulation and resolution of inflammation. Alzheimer's disease (AD) is associated with inflammation mediated by microglia and astrocytes, and ω3 FAs have been proposed as potential treatments for AD. The focus of the present study is on the effects of DHA and EPA on microglial phagocytosis of the AD pathogen amyloid-␤ (A␤), on secreted and cellular markers of immune activity, and on production of brain-derived neurotrophic factor (BDNF). Human CHME3 microglial cells were exposed to DHA or EPA, with or without the presence of A␤ 42 . Phagocytosis of A␤ 42 was analyzed by flow cytometry in conjunction with immunocytochemistry using antibodies to cellular proteins. Secreted proteins were analyzed by ELISA. Both DHA and EPA were found to stimulate microglial phagocytosis of A␤ 42 . Phagocytosis of A␤ 42 was performed by microglia with a predominance of M2 markers. EPA increased the levels of BDNF in the culture medium. The levels of TNF-␣ were decreased by DHA. Both DHA and EPA decreased the pro-inflammatory M1 markers CD40 and CD86, and DHA had a stimulatory effect on the anti-inflammatory M2 marker CD206. DHA and EPA can be beneficial in AD by enhancing removal of A␤ 42 , increasing neurotrophin production, decreasing pro-inflammatory cytokine production, and by inducing a shift in phenotype away from pro-inflammatory M1 activation.

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“…It follows that rats with low omega-3 intake had decreased neuronal plasticity [109], while animals given omega-3 within their diet have increased BDNF expression within the hippocampus and neocortex [110], which are key sites for memory…”

Section: Polyunsaturated Fatty Acidsmentioning

confidence: 99%

Memory consolidation — Mechanisms and opportunities for enhancement

Shaikh

Coulthard

2013

Translational Neuroscience

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Memory consolidation is the process by which relevant information is selected and transferred from a shortterm, fragile state, into a stable, longer term domain from which it can be recalled. Effective memory underpins our ability to carry out everyday activities. When memory consolidation fails, such as in Alzheimer's disease, the consequences can be devastating. Understanding the neurobiology of memory will help develop treatments for patients with memory loss. Here we describe the myriad processes involved in memory consolidation, including cholinergic and dopaminergic neurotransmission predominantly in hippocampal networks. We discuss established therapies as well as potential novel strategies for boosting cognition. Future approaches to enhancement of memory consolidation include not only pharmacological and neurosurgical treatments, but also lifestyle interventions -for example, modifications to sleep, exercise and diet.

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The role of 5-HT1A receptors in fish oil-mediated increased BDNF expression in the rat hippocampus and cortex: A possible antidepressant mechanism

Cited by 105 publications

References 59 publications

Dietary DHA during development affects depression-like behaviors and biomarkers that emerge after puberty in adolescent rats

Dietary DHA during development affects depression-like behaviors and biomarkers that emerge after puberty in adolescent rats

Omega-3 Fatty Acids Enhance Phagocytosis of Alzheimer's Disease-Related Amyloid-β42 by Human Microglia and Decrease Inflammatory Markers

Memory consolidation — Mechanisms and opportunities for enhancement

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