The Role of Abdominal Computed Tomography Scan in Acute Pancreatitis

Al-Khazraji, Ahmed; Hasan, Ahmed Q; Patel, Ishan; Alkhawam, Hassan; Ghrair, Fadi; Lieber, Joseph

doi:10.1097/mpa.0000000000000837

Cited by 4 publications

(2 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One study looked at patients with pancreatitis and found that 16.7% of their study population had an SMV thrombus, while 4.1% had a SMV thrombus with a concomitant portal vein thrombus. 6 Although there are no pathognomonic laboratory findings of MVT, elevated lactate, leukocytosis, and elevated D-dimer levels may be helpful in supporting the diagnosis. 7,8 A recent study found that elevated D-dimer levels may be a specific marker in the early recognition of acute SMV thrombosis, as well as predicting risk, outcomes, and treatment options.…”

Section: Discussionmentioning

confidence: 99%

Acute Superior Mesenteric Venous Thrombosis in a Young Patient Without Risk Factors

Smith¹,

Percy²,

Ritz³

2018

Emerg Med

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Acute Superior Mesenteric Venous Thrombosis in a Young Patient Without Risk Factors

Smith¹,

Percy²,

Ritz³

2018

Emerg Med

View full text Add to dashboard Cite

“…Due to the history of side effects, such as pancreatitis, all patients were routinely monitored to determine pancreatic lipase and amylase enzymes, in an asymptomatic state. Three of the patients did not present symptoms of pancreatitis, however, as there were clinical data and elevation of said enzymes, a computerized axial tomography (CT) [13] was performed to confirm the diagnosis of pancreatitis [14]. (Table 1) shows the total and cumulative doses of L-Asp administered in patients at the time of diagnosis of pancreatitis, as well as the levels of pancreatic amylase and lipase enzymes.…”

Section: Case Reportmentioning

confidence: 99%

"Rapid Asparagine Depletion as a Possible Risk Marker for Pancreatitis in Children with Acute Lymphoblastic Leukemia Under Treatment with L-Asparaginase: Case Report from Five Patients"

Lares‐Asseff

2023

BJSTR

View full text Add to dashboard Cite

We will be describing our experience with five patients diagnosed with acute lymphoblastic leukemia (ALL), who developed L-Asparaginase (L-Asp)-induced pancreatitis during their remission induction stage. The patients were treated, at the State Cancer Center of Durango, Mexico (CECAN-Durango) since December 2021, along with a group of 30 pediatric patients (in the remission induction phase of their treatment) who did not develop pancreatitis. All patients were diagnosed with (ALL) according to criteria from the French American-British Hematology Association (FAB). Once diagnosed, patients were treated according to the St. Jude Total XV protocol. In the protocol group, L-Asp enzyme activity and asparagine (Asp) concentrations were measured on 3 occasions. Population pharmacokinetic/pharmacodynamic (PK/PD) modeling using the previously assembled and validated monolix suite software was used to determine PK/PD parameters. Four of the patients after the ninth administration and one after the sixth administration of L-Asp revealed an increase in amylase and lipase enzymes even though the patients were asymptomatic. Three of the patients had abdominal distension and diffused pain. A computed axial tomography (CAT) scan confirmed the diagnosis of pancreatitis due to the use of L-Asp, which was immediately discontinued. Regarding Asp levels, it was observed that the five patients who developed pancreatitis reached complete depletion earlier than the 30 patients without pancreatitis. By analyzing the decay slope of Asp, we found that this could be a risk. marker for the development of pancreatitis as an adverse effect of the administration of L-Asp in patients with ALL.

show abstract

Population pharmacokinetics and pharmacodynamics of L-asparaginase and its impact on the development of pancreatitis and hypersensitivity reactions in children with leukemia under treatment

Gándara-Mireles,

Lares-Asseff,

Espinoza

et al. 2024

Drug and Chemical Toxicology

View full text Add to dashboard Cite

The Role of Abdominal Computed Tomography Scan in Acute Pancreatitis

Cited by 4 publications

References 10 publications

Acute Superior Mesenteric Venous Thrombosis in a Young Patient Without Risk Factors

Acute Superior Mesenteric Venous Thrombosis in a Young Patient Without Risk Factors

"Rapid Asparagine Depletion as a Possible Risk Marker for Pancreatitis in Children with Acute Lymphoblastic Leukemia Under Treatment with L-Asparaginase: Case Report from Five Patients"

Population pharmacokinetics and pharmacodynamics of L-asparaginase and its impact on the development of pancreatitis and hypersensitivity reactions in children with leukemia under treatment

Contact Info

Product

Resources

About