The role of abnormal metabolic conditions on arterial stiffness in healthy subjects with no drug treatment

Hwang, Hyo-Sang; Ko, Kwang-Pil; Kim, Myeong Gun; Kim, Sihun; Moon, Jeonggeun; Chung, Wook Jin; Shin, Mi Seung; Han, Seung Hwan

doi:10.1186/s40885-016-0049-6

Cited by 8 publications

(4 citation statements)

References 32 publications

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“…It is well-known that age and hypertension are the main causes of arterial stifness [7]. Additionally, Hwang et al [8] have showed that, regardless of age and blood pressure (BP), patients with diabetes mellitus had higher PWV, whereas patients with prediabetes had similar PWV when compared to subjects with normal fasting blood glucose. Moreover, a recent study observed that small changes in fasting glycaemia in metabolic syndrome patients free of diabetes and hypertension are associated with vascular impairment [9].…”

Section: Introductionmentioning

confidence: 99%

Role of dyslipidemia in early vascular aging syndrome

Kılıç¹,

Baydar²,

Elçik³

et al. 2021

Turk J Med Sci

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Background/aim: Arterial stiffness, known as a predictor of early vascular aging, was defined as the main determinant of cardiovascular mortality and morbidity. However, the relationship between lipid profile and increased arterial stiffness is not clear. The aim of this study, to investigate the relationship between lipid profiles and increased arterial stiffness in patients with early vascular aging syndrome. Materials and methods: A total of 1582 participants, 504 (31.8%) of were male and the mean age was 52.8 ±14.2 years. Patients who applied to the hospital for various reasons and who had undergone 24-hour blood pressure Holter monitoring were included in this study. Patients were divided into four groups according to pulse wave velocity (PWV) quartiles (Q1 (<6.3), Q2 (6.3-7.4), Q3 (7.5-8.8), Q4 (>8.8)). Results: We found that in the highest PWV group, patients had higher systolic blood pressure(SBP), diastolic blood pressure (DBP), glucose, BUN, creatinine, urinary albumin excretion (UAE), uric acid(UA), total cholesterol (TC), low-density lipoprotein (LDL-C), Triglycerid (TG) and Non-high-density lipoprotein (HDL-C)levels. Additionally; Diabetes Mellitus (DM), age, Non-HDL-C and TG/ HDL-C levels were detected as independent risk factors of increased PWV in ordinal logistic regression analysis. Conclusion: Our study demonstrates that lipid parameters are strongly correlated with increased PWVvalue and early vascular aging. In daily clinical practice, TG\ HDL-C ratio, 2 known as atherogenic index might be used routinely for predicted of early vascular aging and subclinical atherosclerosis.

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Section: Introductionmentioning

confidence: 99%

Role of dyslipidemia in early vascular aging syndrome

Kılıç¹,

Baydar²,

Elçik³

et al. 2021

Turk J Med Sci

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“…It is well-established that age and hypertension are the main causes of arterial stiffness [ 20 ]. Additionally, Hwang et al [ 21 ] have found that, regardless of age and blood pressure (BP), subjects with diabetes mellitus had higher PWV, whereas subjects with prediabetes had similar PWV when compared to subjects with normal fasting blood glucose. Moreover, we have recently observed that small changes in fasting glycaemia in MetS patients free of diabetes and hypertension are associated with vascular impairment [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Arterial stiffness and its association with clustering of metabolic syndrome risk factors

Lopes-Vicente

Rodrigues

Cepeda

et al. 2017

Diabetol Metab Syndr

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BackgroundMetabolic syndrome (MetS) is associated with structural and functional vascular abnormalities, which may lead to increased arterial stiffness, more frequent cardiovascular events and higher mortality. However, the role played by clustering of risk factors and the combining pattern of MetS risk factors and their association with the arterial stiffness have yet to be fully understood. Age, hypertension and diabetes mellitus seem to be strongly associated with increased pulse wave velocity (PWV). This study aimed at determining the clustering and combining pattern of MetS risk factors and their association with the arterial stiffness in non-diabetic and non-hypertensive patients.MethodsRecently diagnosed and untreated patients with MetS (n = 64, 49 ± 8 year, 32 ± 4 kg/m2) were selected, according to ATP III criteria and compared to a control group (Control, n = 17, 49 ± 6 year, 27 ± 2 kg/m2). Arterial stiffness was evaluated by PWV in the carotid-femoral segment. Patients were categorized and analyzed according MetS risk factors clustering (3, 4 and 5 factors) and its combinations.ResultsPatients with MetS had increased PWV when compared to Control (7.8 ± 1.1 vs. 7.0 ± 0.5 m/s, p < 0.001). In multivariate analysis, the variables that remained as predictors of PWV were age (β = 0.450, p < 0.001), systolic blood pressure (β = 0.211, p = 0.023) and triglycerides (β = 0.212, p = 0.037). The increased number of risk factors reflected in a progressive increase in PWV. When adjusted to systolic blood pressure, PWV was greater in the group with 5 risk factors when compared to the group with 3 risk factors and Control (8.5 ± 0.4 vs. 7.5 ± 0.2, p = 0.011 and 7.2 ± 0.3 m/s, p = 0.012). Similarly, the 4 risk factors group had higher PWV than the Control (7.9 ± 0.2 vs. 7.2 ± 0.3, p = 0.047).ConclusionsThe number of risk factors seems to increase arterial stiffness. Notably, besides age and increased systolic blood pressure, alterations in the triglycerides worsened the stiffness of large vessels, emphasizing the importance in addressing this risk factor in MetS patients.

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“…Currently, many studies have explored the relationship between HbA1c and risk of arterial stiffness, but studies comparing the effect of HbA1c, FBG, PBG, and TyG index on arterial stiffness were sparse. Additionally, most of the studies were cross-sectional (15,16), and the results were inconsistent (4,20,21). Repeated measurement of glucose parameters was not fully considered, and the predictive ability of these parameters for arterial stiffness was not clarified and compared.…”

Section: Introductionmentioning

confidence: 99%

Glycated Hemoglobin and Risk of Arterial Stiffness in a Chinese Han Population: A Longitudinal Study

et al. 2022

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Background and AimsGlycated hemoglobin (HbA1c) associates with the risk of arterial stiffness, and such association can be found between fasting blood glucose (FBG), postprandial blood glucose (PBG), triglyceride-glucose index (TyG index), and arterial stiffness. However, the results were inconsistent, longitudinal studies were sparse, and comparison of these glycemic parameters was less conducted. We aimed to explore the longitudinal relationship between HbA1c and arterial stiffness and compare the effect of the parameters.MethodsData were collected from 2011 to 2019 in Beijing Health Management Cohort (BHMC) study. Cox proportional hazard models were fitted to investigate the association between the parameters and arterial stiffness. A generalized estimation equation (GEE) analysis was conducted to investigate the effect of repeated measurements of glycemic parameters. A receiver operating characteristic (ROC) analysis was performed to compare the predictive value of glycemic parameters for arterial stiffness.ResultsAmong 3,048 subjects, 591 were diagnosed as arterial stiffness during the follow-up. The adjusted hazard ratio (HR) [95% confidence interval (CI)] for arterial stiffness of the highest quartile group of HbA1c was 1.63 (1.22–2.18), which was higher than those of FBG, PBG, and TyG index. The nonlinear association of arterial stiffness with HbA1c and PBG was proved. The robust results of the sensitivity analysis were obtained.ConclusionsHbA1c is an important risk factor of arterial stiffness compared with PBG, FBG, and TyG index, and has a strong predictive ability for arterial stiffness among non-diabetics and the general population.

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The role of abnormal metabolic conditions on arterial stiffness in healthy subjects with no drug treatment

Cited by 8 publications

References 32 publications

Role of dyslipidemia in early vascular aging syndrome

Role of dyslipidemia in early vascular aging syndrome

Arterial stiffness and its association with clustering of metabolic syndrome risk factors

Glycated Hemoglobin and Risk of Arterial Stiffness in a Chinese Han Population: A Longitudinal Study

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