The Role of Access of Joint Fluid to Bone in Periarticular Osteolysis

Aseptic loosening, not only a question of wear: A review of different theories

“…Schmalzried et al (1992a) also discussed the role of high pressure as a cause of osteolysis. Intracapsular pressure is higher in an osteoarthrotic joint than in a normal joint (Schmalzried et al 1997), and this pressure may affect bone which lacks cartilage protection. In normal joints the bone is not exposed to the joint fluid, but when the cartilage is affected either by disease or by trauma the bone is exposed.…”

Treatment of osteochondral defects of the talus

“…87,330 Th e high local fl uid pressure can lead to osteonecrosis, bone resorption, and formation of lytic areas, causing a cyst. 111,345,421 A vicious circle begins, in which damage to the overlying cartilage leads to further subchondral bone damage, and the cartilage is further damaged because the underlying bone is unable to provide support. 434 …”

“…Increased intraosseous pressure has been reported as a cause of pain. 24,345 Th e nerve endings in the subchondral bone are the most probable cause of this pain. 263 …”

Bone sialoprotein‐coated femoral implants are osteoinductive but mechanically compromised

“…Wear is defined as the removal of material from the prosthesis in the form of debris [12]. The wear debris can then gain access to all areas accessible to joint fluid [14] and fluid pressure [l], the concentration of wear particles, typically measuring 0.4-0.7 pm in size, within periprosthetic tissue can extend into billions per gram of tissue [2].…”